Keratoconus

This phase 3 trial tested a new type of corneal cross-linking that does not require removing the surface layer of the eye. It involved 398 people aged 8 to 45 with keratoconus, a condition that thins and bulges the cornea. The treatment uses riboflavin eye drops and ultraviolet l…

This phase 3 trial tested a new way to treat keratoconus, a condition where the cornea thins and bulges, causing blurry vision. The treatment uses special eye drops and ultraviolet light to strengthen the cornea without removing its outer layer. 396 people aged 8 to 45 took part …

This study tested a modified version of corneal collagen cross-linking, a procedure to strengthen the cornea, in 39 people with keratoconus who had thin corneas. Before the standard treatment, doctors added a small air bubble into the cornea to protect the inner layer. The goal w…

This study tested a special intraocular lens (Vivity EDOF) in 10 adults who had cataracts and mild keratoconus, a condition that thins and bulges the cornea. All participants received the lens in both eyes during standard cataract surgery. The goal was to see if the lens could pr…

This study followed 20 people with progressive keratoconus for one year after they received either a standard 30-minute or a faster 10-minute corneal cross-linking treatment. The goal was to see how well each method stopped the disease from getting worse and improved eye shape an…

This study tested two ways to treat keratoconus, a condition where the cornea thins and bulges. One method removes the cornea's outer layer before treatment, while the other keeps it intact and customizes the light pattern. Researchers followed 135 adults for 24 months to see whi…

This early safety study tested a bioengineered corneal implant called LinkCor in 20 adults with advanced keratoconus, a condition that thins and bulges the cornea. The implant is placed inside the cornea to flatten it and improve vision, without needing human donor tissue. Resear…

This early study tested a dexamethasone eye insert placed by a doctor against a standard steroid gel for treating allergy and dry eye symptoms in 36 people with keratoconus who wear gas permeable contact lenses. The goal was to see if the insert improves signs like eyelid bumps a…

This study measured how three common eye surgeries—LASIK, PRK, and corneal cross-linking (CXL)—change the stiffness of the cornea. Using a device called Corvis ST, researchers assessed 150 adults who had undergone one of these procedures at least a month earlier. The goal was to …

This study tested a new questionnaire to better understand eye rubbing habits in people with or suspected keratoconus, a condition where the cornea thins and bulges. Researchers enrolled 292 participants to see if the questionnaire is reliable and useful. The goal is to improve h…

This study tested a new device called the EYESTAR 900, which uses light to take detailed measurements of the eye's shape. 29 people with healthy eyes, corneal scarring, or irregular astigmatism took part. The goal was to see how well the new scanner measures eye geometry compared…

This study looked at 154 people with keratoconus, a condition that thins and bulges the cornea, to understand why it is often worse in one eye than the other. Researchers compared those with uneven severity to those with similar severity in both eyes, focusing on eye rubbing habi…

This study created a nationwide registry to track long-term results of corneal surgeries and diseases. Researchers collected images and data from 19 participants to help understand what makes corneal transplants successful. The goal is to use this information to develop AI that c…

This study tested whether a large language model (like ChatGPT) could collect medical history and suggest eye tests as well as doctors do. 172 patients with non-emergency eye problems took part. The AI's performance was compared to standard care, with senior specialists checking …

This completed study gathered detailed measurements of the eye's surface and visual imperfections from 52 adults with keratoconus, a condition that thins and bulges the cornea. Researchers used a special scanner to map the cornea and sclera. The goal is to use this real-world dat…

This study examined 152 people with hereditary ichthyosis to find out how common eye problems are. Participants received a full eye exam, including tests for dry eye, corneal shape, and vision. The goal was to detect hidden issues like keratoconus, which can lead to vision loss i…