Iris disorder

This study tests whether oral valganciclovir or ganciclovir eye drops can reduce the virus causing eye inflammation and prevent flare-ups. About 117 adults with CMV anterior uveitis will receive either antiviral treatment or placebo for 7 days, then some continue for 12 months. T…

This trial tests a new device called VividFlo, a small implant placed under the eye's surface to help drain fluid and lower pressure in people with glaucoma. The study involves 10 adults with glaucoma in one eye, who will receive the implant during surgery. Researchers will track…

This trial compares two prostate medications, tamsulosin and silodosin, to see how each affects the iris—the colored part of the eye—in men with benign prostatic hyperplasia (BPH). Both drugs can make the iris floppy and the pupil small, which complicates cataract surgery. The st…

This study tests whether insulin eye drops can protect the optic nerve in people with open-angle glaucoma. Researchers will give 90 participants either insulin drops or placebo daily for up to 12 months. The main goal is to check safety, but they will also measure vision changes …

This study tests whether placing a temporary stitch inside a tiny drainage device (Preserflo) can reduce the risk of dangerously low eye pressure after glaucoma surgery. The device is already used in France to lower eye pressure, but low pressure can still happen. About 192 adult…

This study tests a non-invasive laser procedure called direct selective laser trabeculoplasty (DSLT) in 40 adults with pseudoexfoliation glaucoma. The goal is to see if the laser can safely lower eye pressure by at least 20% at 6 and 12 months. Participants will have their eye pr…

This study compares two common prostate medications, tamsulosin and silodosin, to see how they affect pupil size and the thickness of a layer at the back of the eye called the choroid. Men aged 50 and older with benign prostatic hyperplasia (BPH) who have not used these drugs bef…

This study looks at whether the stiffness of the cornea influences how much astigmatism (blurring from an irregularly shaped cornea) develops after cataract surgery in people with pseudoexfoliation syndrome, a condition that weakens eye tissues. Researchers will measure corneal b…

This study follows 70 adults aged 50 and older who are having routine cataract surgery. Half have pseudoexfoliation syndrome, a condition that can weaken eye tissues, and half do not. Researchers measure corneal stiffness before surgery and at several points afterward to see whet…

This study looks at whether a common type of glaucoma eye drop (prostaglandin analogues) can protect the eye's nerve cells directly, not just by lowering eye pressure. Researchers will review medical records from 1500 adults with glaucoma over 3 years, comparing those on prostagl…

This study tests a computer program that learns from patient data to predict how the body will respond during anesthesia. Researchers will check if the AI can accurately forecast changes in brain activity and vital signs. 115 adults having planned surgery will take part. The goal…

This study checks if a small patch placed on the neck can accurately track body temperature during surgery. About 30 adults having planned surgery will wear the patch while standard temperature probes are also used. The goal is to see if the patch matches the accuracy of current …