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Intrinsic asthma
MONDO:0004765An asthma that is triggered by factors not related to allergies such as anxiety, stress, exercise, cold air, dry air, hyperventilation, smoke, viruses, chemical irritants, autonomic imbalance, hormonal deficiencies and psychogenic influences. It is characterized by airway obstruction and inflammation that is at least partially reversible with medication. The symptoms include coughing, wheezing, shortness of breath or rapid breathing, and chest tightness.
Also known as: non-allergic asthma
17 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsSub-types
Broader categories
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Fish oil shows promise for Tough-to-Treat asthma
Disease control CompletedThis study tested whether taking high-dose fish oil (n-3 PUFA) for 6 months can improve asthma control in adults with a specific type of asthma called N-ERD, which is triggered by aspirin or NSAIDs. The 18 participants had poorly controlled asthma despite standard treatment. The …
Phase: PHASE3 • Sponsor: Norfolk and Norwich University Hospitals NHS Foundation Trust • Aim: Disease control
Last updated Jun 27, 2026 13:04 UTC
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New hope for asthma and polyp sufferers? mepolizumab under the microscope
Disease control CompletedThis study looked at whether the drug mepolizumab can improve symptoms in people with a specific combination of asthma, nasal polyps, and sensitivity to aspirin or similar painkillers. 95 adults received either mepolizumab or a placebo injection every month for 16 weeks. Research…
Phase: PHASE4 • Sponsor: Helsinki University Central Hospital • Aim: Disease control
Last updated Jun 27, 2026 12:00 UTC
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Race Walkers' breathing under the microscope: altitude study reveals hidden lung strain
Diagnosis CompletedThis study looked at whether training at high altitudes causes or worsens exercise-induced bronchoconstriction (EIB) in 64 elite race walkers. Participants completed lung function tests, treadmill challenges, and blood draws at both low and high altitudes over 2-4 months. The goa…
Sponsor: Shanghai University of Sport • Aim: Diagnosis
Last updated Jun 27, 2026 11:00 UTC
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Breathing training may ease asthma symptoms during exercise
Symptom relief CompletedThis study tested whether a special breathing exercise, called flow-resistive inspiratory muscle training, could reduce the severity of exercise-induced bronchoconstriction (EIB) in athletes with asthma. Fifteen competitive cyclists or athletes aged 18-35 completed the training a…
Phase: NA • Sponsor: Indiana University • Aim: Symptom relief
Last updated Jun 27, 2026 12:31 UTC
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Could a tiny dose of muscle relaxant make lung scopes safer?
Symptom relief CompletedThis study looked at whether giving a low dose of a muscle relaxant (rocuronium) during bronchoscopy—a procedure where a tube is inserted into the lungs—could reduce complications like throat spasms and coughing. 153 adults having elective bronchoscopy were split into two groups:…
Phase: NA • Sponsor: Harbin Medical University • Aim: Symptom relief
Last updated Jun 27, 2026 09:09 UTC
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New asthma drug may change how patients react to aspirin
Knowledge-focused CompletedThis study looked at how dupilumab, a drug for asthma and nasal polyps, affects reactions to aspirin in people with AERD (a severe form of asthma with sinus issues). 16 adults who were already taking dupilumab for at least 12 weeks took part. Researchers measured breathing, nasal…
Phase: PHASE2 • Sponsor: Scripps Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:24 UTC
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Asthma and obesity study probes Dupilumab's cellular effects
Knowledge-focused CompletedThis study looked at how the drug dupilumab changes gene and protein activity in airway cells from adults with asthma and obesity. Researchers compared allergic and non-allergic participants to understand different treatment responses. The goal was to gather knowledge, not to tes…
Sponsor: Duke University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:00 UTC
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Scientists probe immune Molecule's role in stuffy nose disease
Knowledge-focused CompletedThis study looked at how a molecule called IL-5 affects different cells in the sinuses of people with nasal polyps and a related condition called aspirin-exacerbated respiratory disease. Researchers analyzed tissue samples from 30 participants to understand how IL-5 contributes t…
Sponsor: Brigham and Women's Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:59 UTC