Intestinal motility disease

This study tests whether feeding babies with congenital gastrointestinal issues (like gastroschisis or Hirschsprung disease) only human milk helps them reach full feeds faster than standard care, which may include formula. Researchers will also look at gut bacteria and infection …

This early-stage trial tests whether nicotinamide riboside (a form of vitamin B3) can improve blood flow and brain function in people with smooth muscle dysfunction syndrome (SMDS), a rare genetic condition that narrows arteries and can cause strokes. Fifteen participants will ta…

This study tests a new way to measure how fast food moves through the gut in children with chronic constipation or other bowel emptying disorders. Instead of X-rays, it uses a special light-based imaging technique (MSOT) combined with a safe dye (ICG) and MRI scans. The goal is t…

This study is testing a treatment called sacral neuromodulation, which uses mild electrical pulses to stimulate nerves that control the bowel and bladder. The goal is to see if it can reduce symptoms like severe constipation, stomach pain, and loss of bowel control in children ag…

This study aims to collect medical data and biological samples (blood, urine, stool, and tissue) from up to 4,000 adults with known or suspected gastrointestinal diseases. Participants receive standard medical care at the NIH, and any extra samples or leftover tissue from procedu…

This study aims to find the genes responsible for Hirschsprung disease, a condition where nerve cells are missing from parts of the intestine. Researchers will collect DNA samples from 3,000 people with the disease and their close family members. By analyzing common and rare gene…

This observational study aims to understand stomach electrical activity in children aged 8-25 with digestive issues like slow stomach emptying or chronic pain. Researchers will use a non-invasive device (BSGM) to record stomach signals for up to 4 hours and compare them to health…

This study is creating a large database to collect information on people with rare diseases like amyloidosis, sarcoidosis, and Gaucher disease. Researchers will track patients' health over time, including their symptoms, treatments, and outcomes. The goal is to improve diagnosis …