Intestinal motility disease

This study tests the drug sapropterin (Kuvan) in a single child with multisystem smooth muscle dysfunction syndrome (MSMDS), a rare genetic disorder with no approved treatment. The drug, already approved for another condition, aims to improve growth, blood pressure, and prevent b…

This study tests a new robotic system designed to help surgeons perform chest and belly surgeries in children. It will include 64 kids under 18 who need common surgeries like kidney repair or lung removal. The goal is to see if the robot is safe and works as well as standard surg…

This early study tests whether a daily enema made of salt water and glycerin can help children with fecal incontinence stay clean. The trial will include 30 children aged 3 to 16 who have bowel accidents at least once a week due to conditions like corrected anorectal malformation…

This study compares two surgical techniques—Duhamel and Soave—for treating total colonic Hirschsprung disease, a severe birth defect where nerve cells are missing from the colon. Fifty children who had a first surgery as newborns will receive one of the two procedures. Researcher…

This study tests whether an 8-week physiotherapy program — including breathing exercises, pelvic floor training, and core stabilization — can improve bowel function in 20 children aged 5–18 who have had surgery for Hirschsprung's disease. Participants will keep a bowel diary and …

This study will watch and record information from 120 newborns with serious gut problems admitted to the NICU. Researchers will track what types of emergencies are most common, how long babies stay in the hospital, and how many need surgery. The goal is to better understand these…

Hirschsprung disease is a rare birth defect where nerve cells are missing in part of the colon, causing severe constipation. Surgery to remove the affected section is the main treatment. This study compares two ways to do that surgery: one through the anus only, and another using…

This study will look at 150 infants and children aged 1 month to 4 years who are admitted to a hospital gastroenterology unit with a gastrointestinal disease. The goal is to find out how common electrolyte disturbances (like low sodium or potassium) are in these children. By meas…