Intestinal motility disease

This study compared two surgical techniques for treating Hirschsprung's disease in children: the traditional Soave method and a newer heart-shaped anastomosis. The trial involved 177 children under 14 years old across multiple hospitals. The goal was to see which approach leads t…

This completed trial tested whether a mix of 43 plant polyphenols can counteract health damage from environmental pollutants. 98 adults took either the polyphenol supplement or a placebo for a period. Researchers measured changes in gut health, inflammation, and blood markers to …

This study tested a drug called TOUR006 in 143 adults with chronic kidney disease and high levels of a protein linked to inflammation (hs-CRP). The goal was to see if monthly or quarterly shots could safely lower inflammation. The study is complete, and results will show if the d…

This study looked at whether tiny plastic particles (microplastics) we encounter daily might contribute to obesity and gut problems. Researchers gave 96 overweight or obese adults either a probiotic supplement or a placebo to see if the probiotic could reduce the harmful effects …

This study looked at 20 children with Hirschsprung disease, a condition where part of the bowel lacks nerve cells, causing severe constipation. Researchers compared two surgical methods—Swenson and Soave—to see which one had shorter operation time and better daily bowel movements…

This study tested whether tranexamic acid, a drug that helps blood clot, can lower the chance of infection after gastrointestinal surgery. Over 3,300 adults at higher risk for complications took part. The goal was to see if the drug reduces surgical site infections compared to a …

This study compared two types of laparoscopic surgery (Swenson-like and Soave) for children with Hirschsprung disease, a condition where nerve cells are missing in part of the colon. Forty children were treated at Al-Azhar University Hospitals, and researchers measured bowel func…

This study tested two ways to stimulate sacral nerves in 48 children aged 2-17 with severe constipation and fecal incontinence that didn't improve with standard care. One group got an implanted nerve stimulator, the other a non-invasive patch. The goal was to see if either approa…

This study tested a 12-week online mind-body program for adults with chronic conditions like heart failure, cancer, and liver disease. The program included mindful movement, meditation, breathwork, and coping skills. Researchers measured changes in anxiety, depression, fatigue, a…

This study tested whether giving simethicone (a defoaming agent) and dicyclomine (which reduces gut spasms) before or during an ERCP procedure improves how well doctors can see and work. 90 adults were split into three groups: one got no extra medication, one got simethicone befo…

This study tested a new, smaller bowel irrigation device called Navina Mini in 27 children and teens aged 3 to 17 with bowel problems like severe constipation or leakage. The goal was to see if the device is safe, easy to use, and improves bowel emptying and satisfaction. Results…

This study looked at how Hirschsprung disease, a rare birth defect affecting the bowel, impacts brain development and quality of life in children aged 8 to 13. Researchers tested thinking skills and surveyed families to understand long-term effects after surgery. The goal was to …

This completed study tested whether giving families of children with long-term illnesses (like cancer, heart disease, or premature birth) a tablet computer with a special app helps them manage care at home. Researchers measured satisfaction, cost-effectiveness, and how well famil…

This study measured levels of the laxative PEG 3350 and its breakdown products in the blood and urine of 158 children who were already taking it, compared to children not taking it. The goal was simply to learn how the body processes this medicine, not to change any treatments. R…