Hypogonadotropic hypogonadism
MONDO:0018555Abnormal ovarian or testicular function due to insufficient hormonal stimulation from the hypothalamic-pituitary axis.
Also known as: Normosmic idiopathic hypogonadotropic hypogonadism, central hypogonadism, gonadotropic deficiency, hypogonadism, hypogonadotropic, hypogonadotropic hypogonadism, hypogonadotropic hypogonadism with or without anosmia, low gonadotropins (secondary hypogonadism), nIHH
100 clinical trials for this condition and its sub-types, 19 tagged with Hypogonadotropic hypogonadism itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Hypogonadotropic hypogonadism
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Congenital hypogonadotropic hypogonadism 0 trials · 83 incl. sub-types
25 sub-types
- Combined pituitary hormone deficiencies, genetic form 1 trial · 42 incl. sub-types Sub-types →
- Prader-Willi syndrome 32 trials Sub-types →
- CHARGE syndrome 4 trials Sub-types →
- Hypogonadotropic hypogonadism 7 with or without anosmia 3 trials
- Arhinia, choanal atresia, and microphthalmia 1 trial
- Isolated congenital hypogonadotropic hypogonadism 0 trials · 1 incl. sub-types Sub-types →
- Obesity due to congenital leptin deficiency 1 trial
- Obesity due to leptin receptor gene deficiency 1 trial
- Obesity due to prohormone convertase I deficiency 1 trial
- ANE syndrome 0 trials
- Kallmann syndrome-heart disease syndrome 0 trials
- Laurence-Moon syndrome 0 trials
- Martsolf syndrome 1 0 trials
- Moebius syndrome-axonal neuropathy-hypogonadotropic hypogonadism syndrome 0 trials
- Prader-Willi-like syndrome 0 trials Sub-types →
- Woodhouse-Sakati syndrome 0 trials
- X-linked adrenal hypoplasia congenita 0 trials Sub-types →
- Ataxia-hypogonadism-choroidal dystrophy syndrome 0 trials
- Brachytelephalangy-dysmorphism-Kallmann syndrome 0 trials
- Cerebellar ataxia-hypogonadism syndrome 0 trials Sub-types →
- Familial adrenal hypoplasia with absent pituitary luteinizing hormone 0 trials
- Hypogonadotropic hypogonadism-frontoparietal alopecia syndrome 0 trials
- Hypogonadotropic hypogonadism-retinitis pigmentosa syndrome 0 trials
- Hypogonadotropic hypogonadism-severe microcephaly-sensorineural hearing loss-dysmorphism syndrome 0 trials
- Polyendocrine-polyneuropathy syndrome 0 trials
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Kallmann syndrome 3 trials
18 sub-types
- Hypogonadotropic hypogonadism 1 with or without anosmia 0 trials
- Hypogonadotropic hypogonadism 11 with or without anosmia 0 trials
- Hypogonadotropic hypogonadism 14 with or without anosmia 0 trials
- Hypogonadotropic hypogonadism 15 with or without anosmia 0 trials
- Hypogonadotropic hypogonadism 16 with or without anosmia 0 trials
- Hypogonadotropic hypogonadism 17 with or without anosmia 0 trials
- Hypogonadotropic hypogonadism 18 with or without anosmia 0 trials
- Hypogonadotropic hypogonadism 19 with or without anosmia 0 trials
- Hypogonadotropic hypogonadism 2 with or without anosmia 0 trials
- Hypogonadotropic hypogonadism 20 with or without anosmia 0 trials
- Hypogonadotropic hypogonadism 21 with or without anosmia 0 trials
- Hypogonadotropic hypogonadism 22 with or without anosmia 0 trials
- Hypogonadotropic hypogonadism 3 with or without anosmia 0 trials
- Hypogonadotropic hypogonadism 4 with or without anosmia 0 trials
- Hypogonadotropic hypogonadism 5 with or without anosmia 0 trials
- Hypogonadotropic hypogonadism 6 with or without anosmia 0 trials
- Hypogonadotropic hypogonadism 8 with or without anosmia 0 trials
- Hypogonadotropic hypogonadism 9 with or without anosmia 0 trials
Most studied deeper sub-types
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New drug combo aims to boost IVF success for women with hormone deficiency
Disease control Recruiting nowThis Phase 3 trial tests a new combination of two hormones (follitropin alfa and lutropin alfa) against a standard treatment (hMG) for Japanese women with LH and FSH deficiency who are undergoing IVF. The goal is to see which treatment helps produce more eggs for retrieval. About…
Phase 3 • Sponsor: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany • Aim: Disease control
Last updated Sep 10, 2026 00:00 UTC
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Could a natural hormone help restore fertility?
Disease control Recruiting nowThis study tests whether kisspeptin, a natural hormone, can stimulate reproductive hormones and egg release in 36 men and women with idiopathic hypogonadotropic hypogonadism (IHH). Participants receive kisspeptin injections every 1-4 hours for two weeks. Researchers monitor hormo…
Phase 2 • Sponsor: Stephanie B. Seminara, MD • Aim: Disease control
Last updated Jul 15, 2026 00:00 UTC
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Could a natural hormone restart periods in women with hypothalamic amenorrhea?
Disease control Recruiting nowThis study tests whether kisspeptin, a natural hormone, can trigger the release of other reproductive hormones and help women with hypothalamic amenorrhea (missing periods) release eggs. Twenty women will receive daily injections of kisspeptin for two weeks, with frequent blood t…
Phase 2 • Sponsor: Stephanie B. Seminara, MD • Aim: Disease control
Last updated Jul 15, 2026 00:00 UTC
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Could a weekly pill boost sperm count? new trial seeks answers
Disease control Recruiting nowThis study tests three doses of a drug called leflutrozole to see if it can improve semen quality in men with low sperm count and low testosterone. About 200 men aged 18-49 will take either the drug or a placebo once a week for 16 weeks. Researchers will measure changes in sperm …
Phase 2 • Sponsor: ReproNovo Aps • Aim: Disease control
Last updated Jun 27, 2026 09:08 UTC
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New testosterone injection could help teen boys with delayed puberty
Disease control Recruiting nowThis phase 3 trial is testing XYOSTED, a testosterone injection, in 100 adolescent males who lack or have low testosterone due to hypogonadism. The study lasts 52 weeks, with a 24-month safety follow-up, and aims to see if the treatment can safely induce or continue puberty. Part…
Phase 3 • Sponsor: Halozyme Therapeutics • Aim: Disease control
Last updated Jun 27, 2026 09:06 UTC
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Could pollution and sleep habits be messing with your hormones? new study investigates.
Knowledge-focused Recruiting nowThis study looks at how things in your environment—like pollution, chemicals, diet, and sleep—might affect your hormones and reproductive health. Researchers will follow 300 people aged 8 and older who have conditions like low or high hormone levels, early or late puberty, or inf…
Sponsor: National Institute of Environmental Health Sciences (NIEHS) • Aim: Knowledge-focused
Last updated Sep 11, 2026 00:00 UTC
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Massive new registry aims to uncover hidden causes of missed periods
Knowledge-focused Recruiting nowThis study is building a large registry of women with Functional Hypothalamic Amenorrhea (FHA), a condition where the body stops having periods due to stress, low weight, or excessive exercise. Researchers will track up to 100,000 participants over time to learn how common FHA is…
Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:58 UTC