Could a natural hormone help restore fertility?

NCT ID NCT05896293

Recruiting now Disease control Sponsor: Stephanie B. Seminara, MD Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 14, 2026 · Updated 2 times

Summary

This study tests whether kisspeptin, a natural hormone, can stimulate reproductive hormones and egg release in 36 men and women with idiopathic hypogonadotropic hypogonadism (IHH). Participants receive kisspeptin injections every 1-4 hours for two weeks. Researchers monitor hormone levels and ovarian follicle growth to see if the treatment works.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: kisspeptin (a naturally occurring hormone)
What this could lead to: If it works, this could point toward a new treatment option for people with reproductive hormone deficiencies.
What could go wrong: This is a small, early-stage trial with only 36 participants, so results may not apply to everyone. The treatment is given for just two weeks, so long-term effects are unknown.

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Conditions

The condition(s) this trial relates to.

hypogonadism hypogonadotropic hypogonadism hypogonadotropic hypogonadism 7 with or without anosmia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPOGONADOTROPIC HYPOGONADISM

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States

Contact Email: •••••@•••••

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