Could a natural hormone restore ovulation in women with hypothalamic amenorrhea?
NCT ID NCT05633966
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early study tested whether a naturally occurring hormone called kisspeptin can stimulate reproductive hormones and help women with hypothalamic amenorrhea (a condition where periods stop due to low hormone levels) release eggs. Thirteen women received pulsatile injections of kisspeptin under the skin for two weeks. Researchers monitored egg development with ultrasound and measured hormone levels through frequent blood draws to see if the treatment could trigger ovulation.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- kisspeptin (a naturally occurring hormone)
- What this could lead to
- If it works, this could point toward a new treatment for women with hypothalamic amenorrhea to help them ovulate without traditional hormone therapies.
- What could go wrong
- This is a very small, early Phase 1 trial with only 13 participants. It is designed to test safety and basic effects, not to prove effectiveness. The results may not apply to all women with reproductive disorders.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for HYPOGONADOTROPIC HYPOGONADISM are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Could a stopped period warn of heart trouble? mayo clinic investigates
- Scientists hunt for genes that control puberty
- Can acne drug or hormone shots help men with low sperm count?
- Could a weekly pill boost sperm count? new trial seeks answers
- Could a natural hormone restart periods in women with hypothalamic amenorrhea?
- Massive new registry aims to uncover hidden causes of missed periods