Could a brain hormone fix low sex hormones? small study hints at possibility
NCT ID NCT04648969
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This completed Phase 2 trial tested a natural hormone called kisspeptin in 18 adults with hypogonadotropic hypogonadism, a condition where the body doesn't produce enough sex hormones. Participants received different doses of kisspeptin to see how it affected hormone pulses. The goal was to explore whether kisspeptin could lead to new treatments for this condition.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
kisspeptin
What this could lead to
If successful, this could point toward a new treatment option for people with hypogonadotropic hypogonadism, a condition causing low sex hormones.
What could go wrong
This is a small, early-phase study with only 18 participants, so results may not apply to everyone. The intervention is experimental and not yet proven as a standard therapy.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Massachusetts General Hospital
Boston, Massachusetts, 02114, United States