Could a brain hormone fix low sex hormones? small study hints at possibility

NCT ID NCT04648969

Completed Knowledge-focused Sponsor: Stephanie B. Seminara, MD Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed Phase 2 trial tested a natural hormone called kisspeptin in 18 adults with hypogonadotropic hypogonadism, a condition where the body doesn't produce enough sex hormones. Participants received different doses of kisspeptin to see how it affected hormone pulses. The goal was to explore whether kisspeptin could lead to new treatments for this condition.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: kisspeptin
What this could lead to: If successful, this could point toward a new treatment option for people with hypogonadotropic hypogonadism, a condition causing low sex hormones.
What could go wrong: This is a small, early-phase study with only 18 participants, so results may not apply to everyone. The intervention is experimental and not yet proven as a standard therapy.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hypogonadism hypogonadotropic hypogonadism

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPOGONADOTROPIC HYPOGONADISM

Contacts and locations

Locations

Massachusetts General Hospital

Boston, Massachusetts, 02114, United States

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