New testosterone injection could help teen boys with delayed puberty

NCT ID NCT06689085

Recruiting now Disease control Sponsor: Halozyme Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 trial is testing XYOSTED, a testosterone injection, in 100 adolescent males who lack or have low testosterone due to hypogonadism. The study lasts 52 weeks, with a 24-month safety follow-up, and aims to see if the treatment can safely induce or continue puberty. Participants receive regular injections, and doctors monitor hormone levels, growth, and development.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: testosterone enanthate (XYOSTED injection)
What this could lead to: If successful, this could provide a safe and effective testosterone replacement option for adolescent boys with hypogonadism, helping them go through puberty normally.
What could go wrong: This is a single-arm, open-label study with no placebo group, so results may be less definitive. Long-term safety and effectiveness in adolescents are still being established.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

eunuchism hypogonadism hypogonadism, male hypogonadotropic hypogonadism

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPOGONADISM, MALE

Contacts and locations

Locations

Ann & Robert H. Lurie Children's Hospital of Chicago
RECRUITING

Chicago, Illinois, 60611, United States
Boston Children's Hospital
RECRUITING

Boston, Massachusetts, 02115, United States
Children's Hospital Colorado
RECRUITING

Aurora, Colorado, 80045, United States
Children's Hospital Los Angeles
RECRUITING

Los Angeles, California, 90027, United States
Children's Hospital at Montefiore
RECRUITING

The Bronx, New York, 10467, United States
Children's Hospital of Philadelphia
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
M Health Fairview U Minnesota
RECRUITING

Minneapolis, Minnesota, 55454, United States
MedResearch
RECRUITING

El Paso, Texas, 79902, United States
MultiCare Institute for Research & Innovation
RECRUITING

Tacoma, Washington, 98405, United States
Nemours Children's Specialty Care - Jacksonville
RECRUITING

Jacksonville, Florida, 32207, United States
OUHSC Pediatric Diabetes & Endocrinology
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
Primary Children's Hospital
RECRUITING

Salt Lake City, Utah, 84112, United States
Prisma Health Children's Hospital - Midlands
RECRUITING

Columbia, South Carolina, 29203, United States
Rady Children's Hospital - San Diego
RECRUITING

San Diego, California, 92123, United States
Seattle Children's Hospital
RECRUITING

Seattle, Washington, 98105, United States
Texas Children's Hospital
RECRUITING

Houston, Texas, 77030, United States
The DOCS
RECRUITING

Las Vegas, Nevada, 89113, United States
University of California San Francisco
RECRUITING

San Francisco, California, 94143, United States
University of Massachusetts Memorial Medical Center
RECRUITING

Worcester, Massachusetts, 01655, United States
Washington University School of Medicine in St. Louis
RECRUITING

St Louis, Missouri, 63110, United States

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