Hyperparathyroidism

This study tests whether a low dose of colchicine, a common anti-inflammatory drug, can slow down blood vessel hardening and bone problems in people with stage 3 chronic kidney disease. About 60 adults will take colchicine or receive usual care for 12 months. The goal is to see i…

This study tests whether a common antibiotic for women's UTIs, fosfomycin-trometamol, works well for men with urinary tract infections. Current treatments can have serious side effects and increase antibiotic resistance. The trial will enroll 138 men in primary care and monitor f…

This study compares two vitamin D medications—doxercalciferol (given through a vein) and calcitriol (taken by mouth)—to see which is better at lowering parathyroid hormone levels in kidney dialysis patients. About 98 adults on dialysis with high parathyroid hormone will take part…

This study tests an extended-release vitamin D capsule (CTAP101) in 40 children aged 8 to 17 with stage 3 or 4 chronic kidney disease, secondary hyperparathyroidism, and low vitamin D. Participants take one capsule daily at bedtime for 8 weeks. The goal is to see how the body pro…

This study follows 400 adults with primary hyperparathyroidism who are scheduled for parathyroid surgery. Researchers will measure aldosterone, a hormone that helps control blood pressure, before surgery and at 3, 6, and 12 months after. They will also track blood pressure and us…

This study will follow 1000 adults with advanced chronic kidney disease (stage 4-5) to learn why they face higher risks of bone fractures and heart disease. Researchers will track bone turnover markers, calcium and phosphate levels, and kidney function over time. No new treatment…

This study will examine how quality of life changes after parathyroid surgery in 60 adults with kidney failure and secondary hyperparathyroidism. Researchers will use a database to compare quality-of-life scores, anxiety, and depression before and after surgery. The goal is to be…