Hepatitis

This trial tests an inactivated hepatitis A vaccine called Healive in healthy people aged 1 year and older. Researchers will measure how well the vaccine triggers protective antibodies and check its safety. Adults receive the vaccine in an open-label group, while children are ran…

This Phase 2 trial tests an experimental drug called AHB-137 in 84 adults with chronic hepatitis B who are already on antiviral therapy. The goal is to see if AHB-137 can clear the hepatitis B surface antigen and keep the virus under control, potentially leading to a functional c…

This phase 2 trial tests an experimental drug called AHB-137 in 70 adults with chronic hepatitis B who are already on antiviral pills. The drug is given as a shot under the skin. The goal is to see if it can lower the virus to undetectable levels and allow some people to stop the…

This Phase 3 trial tests an experimental drug called larsucosterol in 350 people with severe alcohol-associated hepatitis. The goal is to see if the drug helps patients survive for 90 days without needing a liver transplant. Participants receive either the drug or a placebo by IV…

This study looks at whether closely monitoring patients with mild to moderate liver inflammation from cancer immunotherapy, and only giving steroids if needed, is as safe and effective as starting high-dose steroids right away. About 56 adults with grade 2 or 3 immune-related hep…

This early-stage study tests the safety of a new drug, Tune-401, in 36 adults with chronic hepatitis B. Participants must already be on standard antiviral medication. The goal is to see if Tune-401 is safe and how the body processes it, not yet to cure the infection.

This study collects blood samples from healthy people, those with benign diseases, and cancer patients to develop a multi-analyte blood test. The test looks for DNA methylation markers that may indicate the presence of various cancers, especially liver cancer. Researchers aim to …

This study tests whether teaching Black male caregivers how to talk about sexual health can help protect Black girls aged 14-18 from HIV, other sexually transmitted infections, and sexual violence. The program involves 612 pairs of girls and their male caregivers. Researchers wil…

This study aims to learn more about liver diseases like hepatitis B, C, and D by observing up to 8,050 participants over time. Participants will have yearly check-ups, blood and urine tests, and liver ultrasounds. Some may be offered experimental treatments if they qualify. The g…

This study looks at liver inflammation (hepatitis) that can occur in cancer patients treated with immune checkpoint inhibitors, a type of immunotherapy. Researchers aim to describe the different patterns of liver injury and how they respond to treatment. By collecting real-world …

This study is testing a mobile app called ePro-Diary HDV for people with hepatitis Delta, a rare but serious liver disease. The app helps patients track their health, communicate with doctors, and remember appointments. Researchers want to see if using the app helps patients atte…

This study looks at whether giving out special syringes with less leftover space (low dead-space) can help reduce the spread of HIV and hepatitis among people who inject drugs. Researchers will talk with participants and track their health in several countries. The goal is to fin…

This study looks at the immune cells inside the liver of people with non-alcoholic fatty liver disease (NAFLD). The goal is to find differences between those with simple fatty liver and those with the more serious form, NASH, which can lead to cirrhosis and liver cancer. Research…