Hemorrhagic disease
MONDO:0002243Spontaneous or near spontaneous bleeding caused by a defect in clotting mechanisms (blood coagulation disorders) or another abnormality causing a structural flaw in the blood vessels (hemostatic disorders).
Also known as: bleeding diathesis, bleeding disorder, bleeding predisposition, bleeding tendency
510 clinical trials for this condition and its sub-types, 108 tagged with Hemorrhagic disease itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
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Sub-types of Hemorrhagic disease
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Hemophilia A 180 trials
5 sub-types
- Severe hemophilia A 50 trials
- Moderately severe hemophilia A 4 trials
- Mild hemophilia A 2 trials
- Hemophilia A with vascular abnormality 0 trials
- Symptomatic form of hemophilia A in female carriers 0 trials
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Purpura 4 trials · 117 incl. sub-types
3 sub-types
- Thrombocytopenic purpura 8 trials · 116 incl. sub-types Sub-types →
- Hyperglobulinemic purpura 0 trials
- Purpura fulminans 0 trials Sub-types →
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Hemophilia B 84 trials · 91 incl. sub-types
4 sub-types
- Severe hemophilia B 9 trials
- Moderately severe hemophilia B 2 trials
- Mild hemophilia B 1 trial
- Symptomatic form of hemophilia B in female carriers 0 trials
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Vascular hemostatic disease 62 trials · 63 incl. sub-types
2 sub-types
- Cavernous hemangioma 1 trial Sub-types →
- Shwartzman phenomenon 0 trials
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Hereditary von Willebrand disease 18 trials · 29 incl. sub-types
5 sub-types
- Von Willebrand disease 3 9 trials
- Von Willebrand disease 2 4 trials · 5 incl. sub-types Sub-types →
- Von Willebrand disease 1 3 trials
- Von Willebrand disease, X-linked form 0 trials
- Platelet-type von Willebrand disease 0 trials
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Inherited bleeding disorder, platelet-type 6 trials · 26 incl. sub-types
28 sub-types
- Glanzmann thrombasthenia 8 trials Sub-types →
- Platelet-type bleeding disorder 10 8 trials
- Congenital thrombotic thrombocytopenic purpura 5 trials
- Macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss 1 trial
- Bernard-Soulier syndrome 0 trials Sub-types →
- Ehlers-Danlos syndrome, fibronectinemic type 0 trials
- Quebec platelet disorder 0 trials
- Scott syndrome 0 trials
- Bleeding diathesis due to thromboxane synthesis deficiency 0 trials
- Bleeding disorder, platelet-type, 21 0 trials
- Bleeding disorder, platelet-type, 22 0 trials
- Bleeding disorder, platelet-type, 24 0 trials
- Bleeding disorder, platelet-type, 25 0 trials
- Cytosolic phospholipase-A2 alpha deficiency associated bleeding disorder 0 trials
- Gray platelet syndrome 0 trials
- Platelet-type bleeding disorder 11 0 trials
- Platelet-type bleeding disorder 12 0 trials
- Platelet-type bleeding disorder 14 0 trials
- Platelet-type bleeding disorder 15 0 trials
- Platelet-type bleeding disorder 16 0 trials
- Platelet-type bleeding disorder 17 0 trials
- Platelet-type bleeding disorder 18 0 trials
- Platelet-type bleeding disorder 19 0 trials
- Platelet-type bleeding disorder 20 0 trials
- Platelet-type bleeding disorder 8 0 trials
- Platelet-type bleeding disorder 9 0 trials
- Platelet-type von Willebrand disease 0 trials
- Primary release disorder of platelets 0 trials
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Acquired hemophilia 2 trials · 8 incl. sub-types
3 sub-types
- Acquired hemophilia A 6 trials
- Acquired factor XI deficiency 0 trials
- Acquired hemophilia B 0 trials
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Factor VII deficiency 6 trials
2 sub-types
- Congenital factor VII deficiency 3 trials
- Acquired factor VII deficiency 0 trials
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Congenital fibrinogen deficiency 2 trials · 6 incl. sub-types
1 sub-type
- Familial dysfibrinogenemia 2 trials · 6 incl. sub-types Sub-types →
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3 sub-types
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Congenital vitamin K-dependent coagulation factors deficiency 0 trials · 4 incl. sub-types
5 sub-types
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Acquired von willebrand syndrome 3 trials
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Factor X deficiency 2 trials
2 sub-types
- Acquired factor X deficiency 1 trial
- Congenital factor X deficiency 0 trials
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Congenital factor XII deficiency 1 trial
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East Texas bleeding disorder 0 trials
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Alpha-2-plasmin inhibitor deficiency 0 trials
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Congenital factor V deficiency 0 trials
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Congenital factor XI deficiency 0 trials
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Congenital factor XIII deficiency 0 trials
2 sub-types
- Factor XIII, A subunit, deficiency of 0 trials
- Factor XIII, b subunit, deficiency of 0 trials
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Hemophilia B leyden 0 trials
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Inherited prekallikrein deficiency 0 trials
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Prothrombin deficiency 0 trials
2 sub-types
- Acquired prothrombin deficiency 0 trials
- Congenital prothrombin deficiency 0 trials
Most studied deeper sub-types
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Could a single pill replace two after heart implant? major trial seeks safer stroke prevention
Disease control OngoingThis study tests whether people with atrial fibrillation who receive a WATCHMAN FLX Pro device can safely take just one blood thinner or aspirin instead of the usual two-drug plan. About 1,857 participants are being followed for six months to compare rates of death, stroke, major…
Sponsor: Boston Scientific Corporation • Aim: Disease control
Last updated Sep 13, 2026 00:00 UTC
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Could a tiny implant replace daily blood thinners for AFib patients?
Disease control OngoingThis large study is testing whether a device called WATCHMAN FLX, which closes off a small pouch in the heart, can be a safe and effective alternative to daily blood thinners (NOACs) for preventing strokes in people with non-valvular atrial fibrillation. The trial involves 3,000 …
Sponsor: Boston Scientific Corporation • Aim: Disease control
Last updated Sep 13, 2026 00:00 UTC
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Could cold platelets stop bleeding better in heart surgery?
Disease control OngoingThis study compares cold-stored platelets to standard room-temperature platelets for controlling bleeding in adults after heart surgery. About 150 patients will be randomly assigned to receive one type. The goal is to see if cold storage is a safe and effective option, and to pla…
Phase 2 • Sponsor: University Health Network, Toronto • Aim: Disease control
Last updated Jul 15, 2026 00:00 UTC
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New device aims to stop internal bleeding safely
Disease control OngoingThis study tests a new medical device called EmboBio to stop bleeding in the abdomen or pelvic area. The device is injected into an artery to block blood flow and control bleeding. The study will include 45 adults in France and will check if the device is safe and works well over…
Sponsor: Embobio Medical • Aim: Disease control
Last updated Jul 04, 2026 00:00 UTC
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New hope for rare bleeding disorder: coagadex trial targets AL amyloidosis
Disease control CancelledThis phase 3 study tests Coagadex, a human clotting factor X, in 15 adults with acquired factor X deficiency caused by AL amyloidosis. The goal is to see if it safely stops active bleeding and helps manage bleeding during surgery. Participants receive the drug on demand for bleed…
Phase 3 • Sponsor: Kedrion S.p.A. • Aim: Disease control
Last updated Jul 01, 2026 00:00 UTC
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New pill shows promise for Hard-to-Treat blood cancers
Disease control OngoingThis study tests a daily oral drug called nemtabrutinib (ARQ 531) in 190 people with blood cancers like lymphoma or leukemia that have come back or not responded to prior treatment. The goal is to find a safe dose and see if the drug can shrink tumors. It is an early-phase trial,…
Phase 1/2 • Sponsor: ArQule, Inc., a subsidiary of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc. (Rahway, NJ USA) • Aim: Disease control
Last updated Jun 27, 2026 13:06 UTC
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New Blood-Clot monitor could cut transfusions in heart surgery
Disease control OngoingThis study tests whether a bedside device called Quantra can help doctors decide when to give blood transfusions during complex heart surgery. The device measures how well a patient's blood clots in real time. Researchers hope this will reduce the number of blood products (like r…
Sponsor: The Cleveland Clinic • Aim: Disease control
Last updated Jun 27, 2026 12:29 UTC
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New hope for myelofibrosis patients with dangerous low platelet counts
Disease control OngoingThis phase 3 study tests a drug called pacritinib against standard treatments chosen by the doctor in people with myelofibrosis who have very low platelet counts (below 50,000). The goal is to see if pacritinib can shrink the spleen and reduce symptoms like tiredness, pain, and i…
Phase 3 • Sponsor: Swedish Orphan Biovitrum • Aim: Disease control
Last updated Jun 27, 2026 12:26 UTC
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Which blood thinner works best after heart device implant? new trial aims to find out
Disease control OngoingThis study compares two approaches—short-term anticoagulation (stronger blood thinners) versus antiplatelet therapy (milder blood thinners)—to prevent clots on a device placed in the heart's left atrial appendage. The trial involves 510 adults who have had this procedure. The goa…
Phase 4 • Sponsor: Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec • Aim: Disease control
Last updated Jun 27, 2026 12:01 UTC
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One-Time gene therapy could free hemophilia patients from frequent infusions
Disease control OngoingThis study tests a one-time gene therapy (valoctocogene roxaparvovec) in 6 Japanese men with severe hemophilia A. The goal is to help their bodies produce their own clotting factor, reducing or stopping the need for regular factor VIII infusions. Participants will be monitored fo…
Phase 3 • Sponsor: BioMarin Pharmaceutical • Aim: Disease control
Last updated Jun 27, 2026 11:03 UTC
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Bleeding breakthrough? study tests tranexamic acid in bariatric surgery
Disease control OngoingThis study looks at whether giving tranexamic acid (a drug that helps blood clot) during weight-loss surgery can reduce dangerous bleeding. About 1000 adults having bariatric surgery will be split into two groups: one gets the drug, the other gets standard care. The goal is to se…
Sponsor: Santa Maria Hospital - GVM Care & Research • Aim: Disease control
Last updated Jun 27, 2026 09:04 UTC
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Heart device vs. pills: which better prevents strokes in AFib patients?
Disease control OngoingThis study tests if a device that closes a small pouch in the heart (left atrial appendage) is safer and more effective than long-term blood thinners for preventing strokes in people with atrial fibrillation. About 2,650 participants with AFib and high stroke risk are randomly as…
Sponsor: Abbott Medical Devices • Aim: Disease control
Last updated Jun 27, 2026 09:03 UTC
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Gene therapy for hemophilia a: how long does it last?
Disease control By invitation onlyThis study checks the long-term safety and effectiveness of a one-time gene therapy (BMN 270) for people with severe hemophilia A. Participants from earlier BioMarin trials will be followed for many years to see if the treatment continues to work and remains safe. The goal is to …
Sponsor: BioMarin Pharmaceutical • Aim: Disease control
Last updated Jun 27, 2026 08:10 UTC
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New study tracks amulet Device's Real-World success in preventing strokes
Disease control OngoingThis study observes over 600 people with atrial fibrillation who received the Amulet device to close a part of the heart called the left atrial appendage. The goal is to see how well the device prevents strokes and bleeding in everyday medical practice. Participants are followed …
Sponsor: Abbott Medical Devices • Aim: Disease control
Last updated Jun 27, 2026 07:52 UTC
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Promising ITP drug trial pulled before it even started
Disease control CancelledThis study was designed to test the safety and tolerability of a new drug called HMPL-523 (sovleplenib) in adults with immune thrombocytopenia (ITP), a condition where the immune system destroys platelets, causing bleeding problems. The trial was withdrawn before enrolling any pa…
Phase 1 • Sponsor: Hutchmed • Aim: Disease control
Last updated Jun 26, 2026 18:23 UTC
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Can a simple drug make kidney biopsies safer for transplant patients?
Disease control By invitation onlyThis study tests whether desmopressin, a drug that helps blood clot, can prevent bleeding during kidney biopsies in transplant patients. Researchers will give 96 high-risk patients either desmopressin or a placebo before the procedure and compare bleeding rates. The goal is to se…
Phase 4 • Sponsor: Hospital de Clinicas de Porto Alegre • Aim: Disease control
Last updated Jun 26, 2026 16:20 UTC
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Family history questions may improve bleeding disorder detection in kids
Knowledge-focused OngoingThis study looks at whether adding simple family history questions to a standard bleeding questionnaire can better identify children who truly have mild bleeding disorders. Researchers will review data from 1,000 children seen at a clinic since 2019. The goal is to see if this co…
Sponsor: Children's Hospital Medical Center, Cincinnati • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:25 UTC
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Storytelling may boost blood thinner use in black heart patients
Knowledge-focused By invitation onlyThis study tests whether watching storytelling videos can help African American and Black patients with atrial fibrillation (an irregular heartbeat) start and continue taking blood thinners to prevent strokes. About 80 adults who are not currently on blood thinners but have a hig…
Sponsor: University of Massachusetts, Worcester • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:06 UTC
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Blood thinner safety in artery surgery under review
Knowledge-focused OngoingThis study reviews the medical records of 500 people who had surgery on major arteries (not heart surgery). It aims to see if taking blood thinners (antiplatelet or anticoagulant drugs) around the time of surgery affects the chance of bleeding or blood clots. The researchers comp…
Sponsor: Petrovsky National Research Centre of Surgery • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:12 UTC
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Study to improve bleeding care in blood thinner users withdrawn
Knowledge-focused CancelledThis study was designed to see if a checklist could help doctors better manage major bleeding in patients taking blood thinners. It planned to include 168 adults in Brazil who were on long-term blood thinners and had a major bleed. The study was withdrawn before any participants …
Sponsor: AstraZeneca • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:59 UTC
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Withdrawn study sought safer biopsies for Bleeding-Prone patients
Knowledge-focused CancelledThis study planned to test a technique called radiofrequency track cautery during liver, kidney, or spleen biopsies in patients at high risk for bleeding. The idea was to use a small heated probe to seal the biopsy track and reduce bleeding. However, the study was withdrawn befor…
Sponsor: Brigham and Women's Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:56 UTC
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Aspirin's hidden legacy: 19,000 seniors tracked for delayed effects
Knowledge-focused OngoingThis study follows over 19,000 older adults who previously took aspirin in a clinical trial. Researchers are monitoring them for delayed effects on cancer, dementia, disability, and death. The goal is to see if aspirin has any long-term benefits or risks years after stopping the …
Sponsor: Anne Murray • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:56 UTC
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Charcoal experiment to reverse blood thinners halted before it began
Knowledge-focused CancelledThis study was designed to see if taking activated charcoal could help clear certain blood thinners (rivaroxaban, apixaban) faster in patients needing an urgent procedure. It planned to enroll 140 adults and measure how quickly the drug left their blood. However, the trial was wi…
Phase 4 • Sponsor: University Hospital, Angers • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:53 UTC