New hope for rare bone marrow cancer patients with dangerous low platelets

NCT ID NCT03165734

First seen Nov 01, 2025 · Last updated May 16, 2026 · Updated 24 times

Summary

This study tests a drug called pacritinib against standard treatments in about 400 people with myelofibrosis, a type of bone marrow cancer, who also have very low platelet counts (below 50,000). The goal is to see if pacritinib can shrink the spleen and improve symptoms like belly pain and night sweats. Participants are randomly assigned to receive either pacritinib or a treatment chosen by their doctor.

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Contacts and locations

Locations

  • ASST Monza - Ospedale San Gerardo

    Monza, Italy

  • ASST Sette Laghi Hospital

    Varese, Italy

  • ASST Spedali Civili Brescia, Hematology Unit

    Brescia, Italy

  • Aktobe Medical Center, Department of Hematology

    Aktobe, Kazakhstan

  • Alfred Hospital, Malignant Hematology and Stem Cell Transplantation Service

    Melbourne, Victoria, Australia

  • All India Institute of Medical Sciences

    Dehradun, Uttarakhand, India

  • American Oncology Partners of Maryland, PA

    Bethesda, Maryland, 20817, United States

  • Andrzej Mielecki Independent Public Clinical Hospital of Medical University of Silesia in Katowice, Department of Hematology and Bone Marrow Transplantation

    Katowice, Poland

  • Azienda Ospedaliero-Universitaria Careggi

    Florence, Italy

  • Barts Health NHS Trust - The Royal London Hospital

    London, United Kingdom, E1 2ES, United Kingdom

  • Bashkiria State Medical University, Department of Internal Medicine

    Ufa, Russia

  • Beatson West of Scotland Cancer Centre

    Glasgow, United Kingdom, G12 0ZD, United Kingdom

  • CHU Hopitaux de Bordeaux - Hôpital Haut-Lévêque

    Pessac, 33604, France

  • CHU Hôpital Amiens Sud

    Amiens, France, 80054, France

  • CHU de Nimes - Hopital Universitaire Caremeau

    Nîmes, France, 30900, France

  • Cancer Institute "Giovanni Paolo II", IRCCS

    Bari, Italy

  • Cancer and Hematology Centers of Western Michigan

    Grand Rapids, Michigan, 49546, United States

  • Center for Hematology

    Astana, Kazakhstan

  • Center for Hematology

    Ust-Kamenogorsk, Kazakhstan

  • Centre Hospitalier Lyon-Sud

    Pierre-Bénite, France

  • Cetus Oncology Inc.

    Belo Horizonte, Minas Gerais, Brazil

  • Cherkasy Regional Oncology Dispensary of Cherkasy Oblast Council, Regional Treatment and Diagnostic Hematology Center, Department of Hematology

    Cherkasy, Ukraine

  • City Clinical Hospital #4" under Dnipro City Council

    Dnipro, Ukraine

  • City Clinical Hospital #40

    Moscow, Russia

  • City Clinical Hospital #7, Hematology Department

    Almaty, Kazakhstan

  • City Clinical Hospital n.a. V.V. Veresaev of the Moscow City Health

    Moscow, Russia

  • City Oncological Center

    Shymkent, Kazakhstan

  • City of Health and Science of Turin

    Turin, Italy

  • City of Hope

    Duarte, California, 91010, United States

  • Cleveland Clinic

    Cleveland, Ohio, 44106, United States

  • Cleveland Clinic Florida

    Weston, Florida, 33331, United States

  • Clinic UZI 4D, LLC

    Pyatigorsk, Russia

  • Clinical Center of Serbia, Clinic of Hematology

    Belgrade, Serbia

  • Clinical Center of Vojvodina, Clinic of Hematology

    Novi Sad, Serbia

  • Clinical Hospital of the Federal University of Parana (HC - UFPR)

    Curitiba, Paraná, Brazil

  • Clinics Hospital, Federal University of Goias - (UFG)

    Goiânia, Goiás, Brazil

  • Coltea Clinical Hospital

    Bucharest, Romania

  • Columbia University Medical Center

    New York, New York, 10017, United States

  • Communal Non-profit enterprise "Regional Center of Oncology", Department of Hematology

    Kharkiv, Ukraine

  • Comprehensive Cancer Centers of Nevada- Twain Office

    Las Vegas, Nevada, 89169, United States

  • Duke University Hospital

    Durham, North Carolina, 27710, United States

  • Eastern Regional Health Authority

    St. John's, Newfoundland and Labrador, Canada

  • Ehime University Hospital

    Tōon, Japan

  • Fejer County St. Gyorgy University Teaching Hospital, Department of Internal Medicine I

    Székesfehérvár, Hungary

  • Fortis Memorial Research Institute(FMRI)

    Gurgaon, Haryana, India

  • Fred Hutchinson Cancer Research Center

    Seattle, Washington, 98109, United States

  • Frederic Chopin Provincial Teaching Hospital No. 1 in Rzeszow, Department of Hematology,

    Rzeszów, Poland

  • Fukushima Medical University Hospital

    Fukushima, Japan

  • Fundeni Clinical Institute

    Bucharest, Romania

  • Gauhati Medical College and Hospital

    Guwahati, Assam, India

  • George Washington University-Medical Faculty Associates

    Washington D.C., District of Columbia, 20037, United States

  • Georgetown University Hospital

    Washington D.C., District of Columbia, 20007, United States

  • Gloucestershire Royal Hospital

    Gloucester, United Kingdom

  • Grodno University Hospital

    Grodno, Belarus

  • Guy's and St Thomas' NHS Foundation Trust - Guy's Hospital

    London, United Kingdom

  • Hackensack University Medical Center

    Hackensack, New Jersey, 07601, United States

  • Hadassah Medical Center, Department of Hematology,

    Jerusalem, Israel

  • Hematology Center

    Karaganda, Kazakhstan

  • Hospital "Infermi" of Rimini

    Rimini, Italy

  • Hospital Amaral Carvalho

    Jaú, São Paulo, Brazil

  • Hospital Clínic de Barcelona

    Barcelona, Spain

  • Hospital Moinhos de Vento

    Porto Alegre, Rio Grande do Sul, Brazil

  • Hospital Sao Rafael

    Salvador, Estado de Bahia, Brazil

  • Hospital Universitario Ramón y Cajal

    Madrid, Spain

  • Hospital del Mar

    Barcelona, Spain

  • Humane Clinic / Atena Research Institute

    Mossoró, Rio Grande do Norte, Brazil

  • Hôpital Saint-Louis

    Paris, France

  • Icahn School of Medicine at Mount Sinai

    New York, New York, 10029, United States

  • Imperial College Healthcare NHS Trust - Hammersmith Hospital

    London, United Kingdom

  • Independent Public Teaching Hospital No.1 in Lublin, Department of Hematooncology, Bone Marrow Transplantation and Chemotherapy

    Lublin, Poland

  • Institute of Blood Pathology and Transfusion Medicine, Department of Hematology

    Lviv, Ukraine

  • Institute of Hematology and Transfusion Medicine, Teaching Department of Hematology

    Warsaw, Poland

  • Integrare Therapeutics

    Fortaleza, Ceará, Brazil

  • Integrated Oncology Center of Rio Grande do Sul - Mother of God Hospital

    Porto Alegre, Rio Grande do Sul, Brazil

  • JSC K. Eristavi National Center For Experimental and Clinical Surgery

    Tbilisi, Georgia

  • Jan Mikulicz Radecki University Hospital in Wroclaw, Department and Clinic of Hematology, Blood Neoplasms and Bone Marrow Transplantation

    Wroclaw, Poland

  • Jedrzej Sniadecki Specialist Hospital in Nowy Sacz, Department of Hematology

    Nowy Sącz, Poland

  • Jewish General Hospital; Clinical Research Unit

    Montreal, Quebec, Canada

  • Jewish Hospital Albert Einstein

    São Paulo, São Paulo, Brazil

  • Johns Hopkins University

    Baltimore, Maryland, 21287, United States

  • Juntendo University Hospital

    Tokyo, Japan

  • Kyiv City Clinical Hospital #9, Hematology Department #1

    Kyiv, Ukraine

  • Kyiv Regional Oncology Center, Department of Hematology,

    Kyiv, Ukraine

  • Kyungpook National University Hospital

    Daegu, South Korea

  • Kyushu University Hospital

    Fukuoka, Japan

  • LTD M.Zodelava's Hematology Center, Department of Hematology

    Tbilisi, Georgia

  • LTD S.Khechinashvili University Hospital

    Tbilisi, Georgia

  • La Conception Hospital

    Marseille, France

  • Lady Davis Carmel Medical Center, Department of Hematology,

    Haifa, Israel

  • Limited Liability Company "City Doctor"

    Kyiv, Ukraine

  • Maggiore Polyclinic Hospital, Fondazione IRCCS Ca' Granda

    Milan, Italy

  • Malkhaz Katsiashvili Multiprofile Emergency Medicine Center LTD

    Tbilisi, Georgia

  • Maryland Oncology Hematology, PA- Columbia

    Columbia, Maryland, 21044, United States

  • Max Super Speciality Hospital Saket (A Unit of Max Healthcare Institute Limited)

    Delhi, India

  • Mayo Clinic Hospital

    Phoenix, Arizona, 85054, United States

  • Mays Cancer Center

    San Antonio, Texas, 78229, United States

  • Meenakshi Mission Hospital And Research Centre (MMHRC)

    Madurai, Tamil Nadu, India

  • Meir Medical Center, Hematology Institute and Blood Bank

    Kfar Saba, Israel

  • Memorial Sloan -Kettering Cancer Center

    New York, New York, 10065, United States

  • Michigan Medicine Hematology Clinic-Rogel Cancer Center

    Ann Arbor, Michigan, 48109, United States

  • Mie University Hospital

    Tsu, Japan

  • Minsk Scientific and Practical Center of Surgery, Transplantology and Hematology

    Minsk, Belarus

  • Morales Meseguer University General Hospital, Department of Hematology and Hemotherapy

    Murcia, Spain

  • Multiprofile Hospital for Active Treatment "Sveta Marina"

    Varna, Bulgaria

  • Multiprofile Hospital for Active Treatment - Sofia, part of Military Medical Academy

    Sofia, Bulgaria

  • Nasz Lekarz Medical Outpatient Clinics Slawomir Jeka

    Torun, Poland

  • National Research Oncology, Oncohematology Center

    Astana, Kazakhstan

  • Netaji Subhash Chandra Bose Cancer Research Institute

    Kolkata, West Bengal, India

  • Nicolaus Copernicus Provincial Multispecialty Oncology and Traumatology Center in Lodz

    Lodz, Poland

  • Nippon Medical School Hospital

    Tokyo, Japan

  • Nirmal Hospital Pvt Ltd

    Surat, Gujarat, India

  • Northwestern Memorial Hospital

    Chicago, Illinois, 60611, United States

  • Nova Scotia Health Authority, Centre for Clinical Research

    Halifax, Nova Scotia, Canada

  • Ochsner Medical Center

    New Orleans, Louisiana, 70121, United States

  • Onco Card Srl

    Brasov, Romania

  • Oregon Health and Science University

    Portland, Oregon, 97239-3098, United States

  • Oxford University Hospitals NHS Trust - Churchill Hospital

    Oxford, United Kingdom

  • Poltava M.V. Sklifosovskyi Regional Clinical Hospital under Poltava Regional Council, Department of Hematology

    Poltava, Ukraine

  • Polyclinic S. Orsola-Malpighi

    Bologna, Italy

  • Polyclinic San Matteo, IRCCS

    Pavia, Italy

  • Postgraduate Institute of Medical Education and Research (PGIMER)

    Chandigarh, Chandigarh, India

  • Pratia Oncology Katowice

    Katowice, Poland

  • Princess Margaret Cancer Centre

    Toronto, Ontario, Canada

  • Prof. Dr. Ion Chiricuta" Institute of Oncology

    Cluj-Napoca, Romania

  • Providence Hematology - Vancouver

    Vancouver, British Columbia, Canada

  • Pusan National University Hospital

    Busan, South Korea

  • Rabin Medical Center, Clinic for Myeloproliferative Disorders

    Petah Tikva, Israel

  • Regional Cancer Care Associates LLC - CCBD Division

    Bethesda, Maryland, 20817, United States

  • Republican Research Center for Radiation Medicine and Human Ecology

    Homyel, Belarus

  • Research Institute of Hematology and Transfusiology

    Saint Petersburg, Russia

  • Rocky Mountain Cancer Centers (US Oncology/McKesson)

    Boulder, Colorado, 80303, United States

  • Royal Hallamshire Hospital, Department of Hematology

    Sheffield, South Yorkshire, United Kingdom

  • Rush University Medical Center

    Chicago, Illinois, 60612, United States

  • S.M. Kirov Military Medical Academy, Department and Clinic for Intermediate-Level Training in Internal Medicine, Hematology Division

    Saint Petersburg, Russia

  • S.P. Botkin City Clinical Hospital

    Moscow, Russia

  • Sahyadri Super Speciality Hospital

    Pune, Maharashtra, India

  • Saint Agnes Hospital

    Baltimore, Maryland, 21229, United States

  • Saint Lucas Hospital of Copacabana

    Rio de Janeiro, Rio de Janeiro, Brazil

  • Samaritano Hospital

    São Paulo, São Paulo, Brazil

  • Samsung Medical Center

    Seoul, South Korea

  • Santa Catarina Health Research and Education Center (CEPEN)

    Florianópolis, Santa Catarina, Brazil

  • Santa Maria della Misericordia University Hospital of Udine

    Udine, Italy

  • Sao Paulo University Clinical Hospital

    São Paulo, São Paulo, Brazil

  • Scientific Institute of Romagna for the Study and Treatment of Cancer (IRST), IRCCS

    Forlì, Italy

  • Semmelweis University SE ÁOK I. sz. Belgyógyászati Klinika

    Budapest, Hungary

  • Seoul National University Hospital

    Seoul, South Korea

  • Severance Hospital

    Seoul, South Korea, 3722, South Korea

  • Shri Ram Cancer Centre, Mahatma Gandhi Medical College & Hospital

    Jaipur, Rajasthan, India

  • Somogy Megyei Kaposi Mór Oktató Kórház

    Kaposvár, Hungary

  • Specialized Hospital for Active Treatment of Hematological Diseases

    Sofia, Bulgaria

  • St. John's Medical College Hospital

    Bengaluru, India

  • State University of Campinas (UNICAMP) - Hemocenter

    Campinas, São Paulo, Brazil

  • Szabolcs-Szatmar-Bereg County Hospitals and University Teaching Hospital, Department of Hematology

    Nyíregyháza, Hungary

  • Tata Medical Center

    Kolkata, West Bengal, India

  • Tbilisi State Medical University and Ingorokva High Medical Technology University Clinic LLC

    Tbilisi, Georgia

  • Texas Oncology- San Antonio

    San Antonio, Texas, 78240, United States

  • The Catholic University of Korea, St. Mary's Hospital

    Seoul, South Korea

  • The James Cancer Hospital and Solove Research Institute

    Columbus, Ohio, 43210, United States

  • The Perth Blood Institute

    Perth, Western Australia, Australia

  • The Sarah Cannon Research Institute-Tennessee Oncology

    Nashville, Tennessee, 37203, United States

  • The Tel Aviv Sourasky Medical Center, Department of Internal Medicine

    Tel Aviv, Israel

  • The University of Chicago Medical Center

    Chicago, Illinois, 60637, United States

  • The University of Texas MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • Tohoku University Hospital

    Miyagi, Japan

  • Tokyo Medical University Hospital

    Tokyo, Japan

  • Tom Baker Cancer Center, Internal Medicine/Hematology

    Calgary, Alberta, Canada

  • UCLA David Geffen School of Medicine

    Los Angeles, California, 90095, United States

  • UPMC Hillman Cancer Center

    Pittsburgh, Pennsylvania, 15232, United States

  • USC Norris Comprehensive Cancer Center

    Los Angeles, California, 90033, United States

  • Umberto I Polyclinic of Rome

    Rome, Italy

  • United Hospitals Villa Sofia Cervello

    Palermo, Italy

  • University Clinical Center in Gdansk

    Gdansk, Poland

  • University Clinical Center of Sarajevo

    Sarajevo, Bosnia and Herzegovina

  • University Clinical Centre of the Republic of Srpska

    Banja Luka, Bosnia and Herzegovina

  • University Clinical Hospital of Salamanca, Department of Hematology

    Salamanca, Spain

  • University Clinical Hospital of Valencia, Department of Hematology and Medical Oncology

    Valencia, Spain

  • University Hospital "Federico II"

    Naples, Italy

  • University Hospital "Maggiore della Carita" of Novara

    Novara, Italy

  • University Hospital 12 de Octubre, Department of Hematology

    Madrid, Spain

  • University Hospital Brno

    Brno, Czechia

  • University Hospital Center of Poitiers

    Poitiers, France

  • University Hospital Kralovske Vinohrady, Clinic of Internal Hematology

    Prague, Czechia

  • University Hospital Olomouc

    Olomouc, Czechia

  • University Hospital Plzen

    Pilsen, Czechia

  • University Hospital Vall d'Hebron

    Barcelona, Spain

  • University Hospital Virgen del Rocio (HUVR)

    Seville, Spain

  • University Hospital in Krakow

    Krakow, Poland

  • University Multiprofile Hospital for Active Treatment "Dr. Georgi Stranski"

    Pleven, Bulgaria

  • University Multiprofile Hospital for Active Treatment "Sveti Georgi", Plovdiv

    Plovdiv, Bulgaria

  • University Polyclinic Foundation "Agostino Gemelli"

    Rome, Italy

  • University Teaching Hospital in Bialystok

    Bialystok, Poland

  • University of Alabama at Birmingham, (UAB) Hospital, Comprehensive Cancer Center

    Birmingham, Alabama, 35294, United States

  • University of Alberta

    Edmonton, Alberta, Canada

  • University of Colorado Cancer Center

    Aurora, Colorado, 80045, United States

  • University of Debrecen Clinical Center (Debreceni Egyetem Klinikai Központ)

    Debrecen, Hungary

  • University of Kansas Cancer Center and Medical Pavilion

    Westwood, Kansas, 66205, United States

  • University of Miyazaki Hospital

    Miyazaki, Japan

  • University of Rochester

    Rochester, New York, 14642, United States

  • University of Utah - Huntsman Cancer Institute

    Salt Lake City, Utah, 84112, United States

  • University of Yamanashi Hospital

    Chūō, Japan

  • V.A. Almazov North-West Federal Medical Research Center, Institute of Oncology and Hematology, Scientific Department of Clinical Oncology

    Saint Petersburg, Russia

  • Volgograd Regional Clinical Oncology Center

    Volgograd, Russia

  • Washington University School of Medicine-Siteman Cancer Center

    St Louis, Missouri, 63110, United States

  • Weill Cornell Medical College

    New York, New York, 10021, United States

  • Westmead Hospital

    Sydney, New South Wales, Australia

  • Yale School of Medicine

    New Haven, Connecticut, 06510, United States

  • Yashoda Hospitals

    Hyderabad, Telangana, India

Conditions

Explore the condition pages connected to this study.