HELLP syndrome
MONDO:0008585A life-threatening condition that can potentially complicate pregnancy. It is named for 3 features of the condition: H emolysis, E levated L iver enzyme levels, and L ow P latelet levels. It typically occurs in the last 3 months of pregnancy (the third trimester) but can also start soon after delivery. A wide range of non-specific symptoms may be present in women with HELLP syndrome. Symptoms may include fatigue; malaise; fluid retention and excess weight gain; headache; nausea and vomiting; pain in the upper right or middle of the abdomen; blurry vision; and rarely, nosebleed or seizures. The cause of HELLP syndrome is not known, but certain risk factors have been associated with the condition. It is most common in women with preeclampsia or eclampsia. If not diagnosed and treated quickly, HELLP syndrome can lead to serious complications for the mother and baby.The main treatment is to deliver the baby as soon as possible, even if premature. Treatment may also include medications needed for the mother or baby, and blood transfusion for severe bleeding problems.
Also known as: hemolysis, elevated liver enzymes, low platelets in pregnancy, hemolysis-elevated liver enzymes-low platelet count syndrome, hemolysis-elevated liver enzymes-low platelets syndrome, PEE1, PREECLAMPSIA/eclampsia 1, PREG1, hemolysis, elevated liver enzymes, and low platelet count, hemolysis, elevated liver enzymes, lowered platelets
28 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsBroader categories
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Could cutting salt after childbirth tame dangerous blood pressure?
Disease control Not yet recruitingThis trial tests whether a low-sodium diet can improve blood pressure control in people who had a hypertensive disorder of pregnancy. Participants receive either a provided diet with less than 2000 mg of sodium per day or a standard diet with no salt restrictions for the first we…
Phase: NA • Sponsor: Women and Infants Hospital of Rhode Island • Aim: Disease control
Last updated Aug 14, 2026 00:00 UTC
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A personal guide to better heart health after pregnancy complications
Disease control Not yet recruitingThis study tests whether a patient navigator — a trained staff member who helps connect people with health services — can improve long-term heart health for those who had high blood pressure disorders during pregnancy. About 60 participants will be randomly assigned to receive ei…
Phase: NA • Sponsor: Boston Medical Center • Aim: Disease control
Last updated Jul 16, 2026 00:00 UTC
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Can remote monitoring and community support tame postpartum high blood pressure?
Disease control Not yet recruitingThis study tests whether combining a Bluetooth blood pressure monitor with regular support from a community health worker can help Black women control high blood pressure after pregnancy. About 404 women will be randomly assigned to either this extra support or standard care. The…
Phase: NA • Sponsor: University of Nebraska • Aim: Disease control
Last updated Jun 27, 2026 12:37 UTC
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Simple blood test may spot Life-Threatening HELLP syndrome sooner
Diagnosis Not yet recruitingThis study looks at whether a substance in the blood called sCD163 can help doctors find HELLP syndrome early in pregnant women. HELLP is a rare but serious condition that can harm the liver and blood. Researchers will compare sCD163 levels in 70 pregnant women—some with HELLP an…
Sponsor: Assiut University • Aim: Diagnosis
Last updated Jun 27, 2026 07:53 UTC
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Vitamin d trial aims to protect pregnant women from Life-Threatening conditions
Prevention Not yet recruitingThis study tests whether taking 2,000 IU of vitamin D daily during pregnancy can prevent preeclampsia, eclampsia, and HELLP syndrome in about 2,000 pregnant women in Uganda. Half the women will receive vitamin D and half a placebo, and researchers will track outcomes up to six we…
Phase: PHASE4 • Sponsor: St Mary's Hospital, Lacor • Aim: Prevention
Last updated Jun 27, 2026 12:03 UTC
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Could a safer drug replace magnesium for seizure prevention in pregnancy?
Prevention Not yet recruitingThis study tests whether levetiracetam, a seizure medication, works as well as magnesium sulfate to prevent seizures in pregnant people with severe preeclampsia. About 1,240 participants at 32 weeks or more will be randomly assigned to one of the two drugs. The goal is to see if …
Phase: PHASE3 • Sponsor: Nebraska Methodist Health System • Aim: Prevention
Last updated Jun 27, 2026 07:55 UTC
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Morning workouts may tame blood pressure in glaucoma patients
Knowledge-focused Not yet recruitingThis study looks at whether different types of exercise (like walking or strength moves) and timing (morning vs. evening) can safely lower blood pressure in people with glaucoma and high blood pressure. About 60 adults will try four exercise sessions, and their blood pressure and…
Phase: NA • Sponsor: KU Leuven • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:05 UTC
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Blood markers may predict danger in pregnancy condition
Knowledge-focused Not yet recruitingThis study will check if certain blood markers (like platelet counts and inflammation levels) can help predict serious complications in pregnant women with HELLP syndrome, a rare but dangerous condition. Researchers will follow 60 women to see how these markers relate to problems…
Sponsor: Sohag University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:00 UTC