HELLP syndrome
MONDO:0008585A life-threatening condition that can potentially complicate pregnancy. It is named for 3 features of the condition: H emolysis, E levated L iver enzyme levels, and L ow P latelet levels. It typically occurs in the last 3 months of pregnancy (the third trimester) but can also start soon after delivery. A wide range of non-specific symptoms may be present in women with HELLP syndrome. Symptoms may include fatigue; malaise; fluid retention and excess weight gain; headache; nausea and vomiting; pain in the upper right or middle of the abdomen; blurry vision; and rarely, nosebleed or seizures. The cause of HELLP syndrome is not known, but certain risk factors have been associated with the condition. It is most common in women with preeclampsia or eclampsia. If not diagnosed and treated quickly, HELLP syndrome can lead to serious complications for the mother and baby.The main treatment is to deliver the baby as soon as possible, even if premature. Treatment may also include medications needed for the mother or baby, and blood transfusion for severe bleeding problems.
Also known as: hemolysis, elevated liver enzymes, low platelets in pregnancy, hemolysis-elevated liver enzymes-low platelet count syndrome, hemolysis-elevated liver enzymes-low platelets syndrome, PEE1, PREECLAMPSIA/eclampsia 1, PREG1, hemolysis, elevated liver enzymes, and low platelet count, hemolysis, elevated liver enzymes, lowered platelets
28 clinical trials for this condition and its sub-types.
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New study tests enalapril to shield new moms' hearts after preeclampsia
Disease control Recruiting nowThis study looks at whether giving enalapril, a standard blood pressure medicine, to women who had preeclampsia during pregnancy can help control their blood pressure after childbirth. Researchers will enroll 60 postpartum women and randomly assign them to enalapril or usual care…
Phase: PHASE3 • Sponsor: Women and Infants Hospital of Rhode Island • Aim: Disease control
Last updated Aug 08, 2026 00:03 UTC
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Couples who sleep together, get healthy together? new study tests sleep program for partners
Disease control Recruiting nowThis pilot study tests whether a sleep health program designed for couples can improve sleep and blood pressure. Fifty couples will take part in an 8-week program that includes sleep education, coaching, and a Fitbit to track sleep. The goal is to see if working together as a tea…
Phase: NA • Sponsor: Columbia University • Aim: Disease control
Last updated Jun 27, 2026 13:06 UTC
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New study aims to keep moms healthy after birth
Disease control Recruiting nowThis study tests a new way of caring for new mothers and their babies together, called MOMI PODS. It focuses on moms who had heart or mental health problems during pregnancy. The goal is to see if this coordinated care model improves health and reduces risks like postpartum depre…
Phase: NA • Sponsor: Ohio State University • Aim: Disease control
Last updated Jun 27, 2026 12:33 UTC
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Could a drug for rare blood disorder help pregnant women with severe preeclampsia?
Disease control Recruiting nowThis Phase 2 trial tests ravulizumab (Ultomiris) in 14 pregnant individuals with severe preeclampsia or HELLP syndrome before 34 weeks of pregnancy. The drug aims to block part of the immune system that may drive these dangerous conditions. Researchers will measure blood markers …
Phase: PHASE2 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated Jun 27, 2026 12:24 UTC
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New study tests smart blood pressure monitoring to protect new moms
Disease control Recruiting nowThis study tests a cloud-connected blood pressure monitoring program for new mothers with high blood pressure disorders. The goal is to see if remote monitoring helps more women track their blood pressure after giving birth and reduces hospital readmissions. About 540 pregnant an…
Sponsor: University of South Carolina • Aim: Disease control
Last updated Jun 27, 2026 11:03 UTC
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Postpartum blood pressure control may stop preeclampsia from leading to lifelong hypertension
Prevention Recruiting nowThis trial tests whether starting intensive blood pressure medication soon after childbirth can prevent chronic hypertension in women who had preeclampsia. Participants are randomly assigned to receive nifedipine ER when their blood pressure reaches different thresholds during th…
Phase: NA • Sponsor: Medical College of Wisconsin • Aim: Prevention
Last updated Jul 22, 2026 00:00 UTC
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Egg white extract could help tame blood sugar and pressure
Symptom relief Recruiting nowThis early study tests whether a peptide called IRW, found in egg white hydrolysate, can help manage high blood sugar and blood pressure. About 28 participants at risk for or with type 2 diabetes will consume a smoothie with the peptide on four separate days, while a healthy cont…
Phase: PHASE1 • Sponsor: University of Alberta • Aim: Symptom relief
Last updated Jun 27, 2026 11:01 UTC
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Urine clues may spot Pre-Eclampsia risk in hypertensive pregnancies
Knowledge-focused Recruiting nowThis study looks at whether tiny particles from blood vessels, found in urine, can help predict which pregnant women with high blood pressure will develop a dangerous condition called pre-eclampsia. Researchers will measure these particles in 110 pregnant women at two points duri…
Phase: NA • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 26, 2026 16:35 UTC
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Preeclampsia aftermath: new study tracks heart and kidney risks
Knowledge-focused Recruiting nowThis study follows 100 women who had preeclampsia, HELLP syndrome, or kidney problems during pregnancy. Researchers will measure blood vessel stiffness and collect blood samples for a biobank. The goal is to better understand long-term heart and kidney health after these conditio…
Sponsor: University Hospital Schleswig-Holstein • Aim: Knowledge-focused
Last updated Jun 26, 2026 12:37 UTC