Hantavirus infectious disease

This study tested two DNA vaccines designed to prevent hemorrhagic fever with renal syndrome caused by Hantaan and Puumala viruses. A total of 132 healthy adults received up to four doses of vaccine using a needle-free jet injector. The main goal was to see if the vaccines trigge…

This study tested whether switching from one immunosuppressant to everolimus, along with lowering overall immunosuppression, helps clear BK virus better than just lowering immunosuppression alone. The trial involved 130 kidney transplant recipients with BK virus in their blood. T…

This study looked at whether giving hospital-level care to acutely ill adults in their own homes in rural areas works well. 160 people with various conditions like infections, heart failure, or COPD took part. The goal was to see if this approach could lower costs and help patien…

This study tested an antibody drug called AntiBKV in 95 kidney transplant patients with BK virus infection. The virus can damage the new kidney if not controlled. Patients received four doses of the drug or a placebo over four months. The goal was to see if the drug could clear t…

This study looked at how well a new, quick finger-prick test (LumiraDx CRP) measures CRP levels compared to a standard lab test. CRP is a marker of infection, inflammation, or tissue injury. 79 adults with symptoms of these conditions took part. The goal was to see if the new tes…

This early study tested whether a special PET scan using a radioactive form of vitamin B9 (11C-PABA) can help doctors see infections deep inside the body. Researchers scanned 13 healthy people and patients with known or suspected infections. The goal was to see if this method can…

This study tested whether giving intravenous immunoglobulins (IVIG) could prevent BK virus infection in kidney transplant recipients. The virus often causes graft problems. Researchers enrolled 359 patients with low antibody levels against their donor's virus strain and gave some…

This completed study looked at 378 kidney transplant patients to see if measuring antibodies against BK virus before transplant could predict whether the virus would reactivate after surgery. Researchers used a lab-made virus-like particle to test for five different BK virus type…

This study looked at whether a special blood test could predict BK virus infection in people who had a kidney transplant. The test measured how certain immune cells (T cells) react to the virus. Researchers studied 80 kidney transplant recipients to see if this test could help ca…

This study looked at 156 critically ill patients to find out what factors help achieve the right levels of beta-lactam antibiotics in the blood. Researchers collected clinical data and used therapeutic drug monitoring to see which patients reached target concentrations. The goal …