Fibrous dysplasia
MONDO:0000845A genetic, non-inheritable disorder caused by osteoblastic differentiation defects that result in the replacement of bone marrow and trabecular bone by fibrous stroma and immature bone. It usually affects a single bone and less frequently multiple bones. Skull, femur, tibia, and humerus are the most frequently affected bones. It manifests with pain, deformities, and fractures.
Also known as: fibrous dysplasia of bone
11 clinical trials for this condition and its sub-types.
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Broader categories
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Experimental drug aims to fix Bone-Weakening phosphate problem in rare disease
Disease control CompletedThis study tested a drug called burosumab in 12 people with fibrous dysplasia who also had low blood phosphate, which can make bones weaker. Participants injected the drug at home once or twice a month for 48 weeks. The main goal was to see if the drug could raise phosphate level…
Phase 2 • Sponsor: National Institute of Dental and Craniofacial Research (NIDCR) • Aim: Disease control
Last updated Jun 27, 2026 09:01 UTC
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Could a bone drug halt skeletal damage in kids with rare disease?
Disease control CompletedThis study tested a drug called denosumab in 15 children aged 4 to 14 with fibrous dysplasia, a rare bone disease that causes weak spots and fractures. The goal was to see if the drug could stop bone lesions from growing during childhood. Participants received injections every 4 …
Phase 2 • Sponsor: National Institute of Dental and Craniofacial Research (NIDCR) • Aim: Disease control
Last updated Jun 27, 2026 08:12 UTC
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New hope for rare bone disease pain?
Disease control CompletedThis study tested a drug called tocilizumab for people with fibrous dysplasia of bone who still had pain after standard treatment. The drug blocks a protein linked to bone breakdown. Nineteen adults participated in this small, early-stage trial to see if the drug could reduce bon…
Phase 2 • Sponsor: Hospices Civils de Lyon • Aim: Disease control
Last updated Jun 27, 2026 07:53 UTC
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Scientists probe mysterious bone pain in rare disorder
Knowledge-focused CompletedThis study aims to understand why people with fibrous dysplasia of bone or McCune-Albright syndrome experience chronic pain. Researchers will compare pain responses in 40 adults (20 patients and 20 healthy volunteers) using heat and cold tests. The goal is to see if the nervous s…
Sponsor: University Hospital, Clermont-Ferrand • Aim: Knowledge-focused
Last updated Aug 23, 2026 00:00 UTC
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Blood test may predict bone disease severity
Knowledge-focused CompletedThis study looks at whether a protein called periostin is higher in the blood of people with fibrous dysplasia, a rare bone disease that can cause pain and fractures. Researchers will take blood samples from 65 patients and compare periostin levels to how many bones are affected …
Sponsor: Hospices Civils de Lyon • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:05 UTC
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Brain scans seek clues to mysterious bone pain
Knowledge-focused CompletedThis study looked at why people with Fibrous Dysplasia/McCune-Albright Syndrome feel pain, even when their bones don't show much damage. Researchers used brain scans and pain questionnaires in 37 patients and healthy volunteers. The goal was to understand the root causes of pain,…
Sponsor: Boston Children's Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:03 UTC
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Tiny RNA clues may explain bone disease differences
Knowledge-focused CompletedFibrous dysplasia is a rare bone disease that causes pain, fractures, and deformities, but its severity varies widely for unknown reasons. This study looked at 24 adults—some with the disease and some without—to see if small molecules called microRNAs in blood and bone tissue are…
Sponsor: Hospices Civils de Lyon • Aim: Knowledge-focused
Last updated Jun 26, 2026 14:12 UTC