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Fibrous dysplasia

MONDO:0000845

A genetic, non-inheritable disorder caused by osteoblastic differentiation defects that result in the replacement of bone marrow and trabecular bone by fibrous stroma and immature bone. It usually affects a single bone and less frequently multiple bones. Skull, femur, tibia, and humerus are the most frequently affected bones. It manifests with pain, deformities, and fractures.

Also known as: fibrous dysplasia of bone

11 clinical trials for this condition and its sub-types.

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Sub-types

Polyostotic fibrous dysplasia (8) Monostotic fibrous dysplasia (0) Panostotic fibrous dysplasia (0)

Broader categories

Disease (717) Musculoskeletal system disorder (214) Bone disorder (51) Human disease (15) Bone remodeling disease (5) Skeletal system disorder (4) Disease by body system or component (0)
Trials to join now! 3 Not yet finished but already full! 1 Completed 7
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  • New computer model aims to predict fractures in rare bone disorder patients

    Knowledge-focused Ongoing

    This study is testing whether a computer tool called MEKANOS can better predict the risk of hip fractures in people with Fibrous Dysplasia or McCune-Albright Syndrome. Researchers will take CT scans of the femur and use the tool to calculate bone strength. The goal is to improve …

    Sponsor: Hospices Civils de Lyon • Aim: Knowledge-focused

    Last updated Jun 27, 2026 12:03 UTC

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