Cure My Disease

Don't miss your cure!

 Log in / Sign up

Brain scans seek clues to mysterious bone pain

NCT ID NCT04125862

Knowledge-focused Sponsor: Boston Children's Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at why people with Fibrous Dysplasia/McCune-Albright Syndrome feel pain, even when their bones don't show much damage. Researchers used brain scans and pain questionnaires in 37 patients and healthy volunteers. The goal was to understand the root causes of pain, not to test a treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

37 people

The number who actually took part.

Started

Jan 2021

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

10 to 45 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria (FD/MAS patients): * Male and Female subjects * 10-45 years of age * English Speaking ability sufficient to comprehend consent (with parental assistance if minor) * Diagnosis of Fibrous Dysplasia Exclusion Criteria for patients: * Younger than 10 or older than 45 years old * Weight \> 285 lbs (weight limit of the MRI table and \< 36lbs) * Surgery leaving implanted material * Contraindications to MRI scanning and PET scanning (including presence of a cardiac pacemaker or pacemaker wires, metallic particles in the body, vascular clips in the head or previous neurosurgery, prosthetic heart valves, claustrophobia, previous significant research related exposure to ionizing radiation) Exclusion Criteria for healthy controls: Same as for the patients, with the addition of the following: • Use of recreational or illicit drugs History of chronic pain

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Fibrous dysplasia/McCune-Albright syndrome are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

fibrous dysplasia McCune-Albright syndrome polyostotic fibrous dysplasia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Fibrous dysplasia/McCune-Albright syndrome

Contacts and locations

Locations

  • Boston Children's Hospital

    Boston, Massachusetts, 02115, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.