Familial isolated arrhythmogenic right ventricular dysplasia
MONDO:0016342Familial isolated arrhythmogenic right ventricular dysplasia (ARVC) is the familial autosomal dominant form of ARVC, a heart muscle disease characterized by life-threatening ventricular arrhythmias with left bundle branch block configuration that may manifest with palpitations, ventricular tachycardia, syncope and sudden fatal attacks, and that is due to dystrophy and fibro-fatty replacement of the right ventricular myocardium that may lead to right ventricular aneurysms.
Also known as: familial isolated ARVC, familial isolated ARVD, familial isolated arrhythmogenic right ventricular cardiomyopathy, familial isolated arrhythmogenic right ventricular dysplasia, familial isolated arrhythmogenic ventricular cardiomyopathy, familial isolated arrhythmogenic ventricular dysplasia
16 clinical trials for this condition and its sub-types.
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Broader categories
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One-Time gene infusion aims to fix inherited heart disease
Disease control Recruiting nowThis early-stage trial tests a single intravenous dose of a gene therapy called RP-A601 in 9 adults with a genetic heart condition (PKP2-ACM) that causes dangerous heart rhythms and heart failure. The therapy delivers a working copy of the PKP2 gene to heart cells to restore prot…
Phase: PHASE1 • Sponsor: Rocket Pharmaceuticals Inc. • Aim: Disease control
Last updated Jun 27, 2026 12:08 UTC
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Heart scans may unlock hidden risks in minority communities
Knowledge-focused Recruiting nowThis study is looking at whether advanced heart imaging, especially cardiac MRI, can help identify the cause of cardiomyopathy and predict risks like death or heart failure in a diverse group of patients. The research focuses on adults in the Bronx, including many from Hispanic a…
Sponsor: Montefiore Medical Center • Aim: Knowledge-focused
Last updated Aug 12, 2026 00:00 UTC
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Heart disease detective: 1,000-Person study hunts for hidden genetic triggers of sudden cardiac death
Knowledge-focused Recruiting nowThis study is looking for new genes and blood markers linked to arrhythmogenic cardiomyopathy (AVC), a genetic heart condition that can lead to heart failure and sudden cardiac arrest. Researchers will enroll 1,000 people, including patients with AVC or unexplained cardiac arrest…
Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:25 UTC
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10,000 heart patients join online registry to unlock secrets of cardiomyopathy
Knowledge-focused Recruiting nowThis study is building a large online registry of 10,000 adults with cardiomyopathy or myocarditis, plus those with a strong family history. Researchers will track participants over time to see how many experience serious events like heart failure, dangerous heart rhythms, or dea…
Sponsor: Imperial College London • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:01 UTC
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AI could help predict sudden cardiac death in hereditary heart disease patients
Knowledge-focused Recruiting nowThis study aims to improve how doctors predict the risk of sudden cardiac death or heart failure in people with inherited heart diseases. Researchers will use artificial intelligence to analyze data from 1,000 participants, including medical history, ECGs, imaging, genetic tests,…
Sponsor: Nantes University Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:00 UTC
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Researchers to track rare heart disease in 36 patients
Knowledge-focused Recruiting nowThis study aims to describe how a genetic heart condition called PKP2-ACM naturally progresses over time in people who receive standard care. Researchers will monitor heart rhythm, biomarkers, and quality of life in 36 participants aged 12 and older. The goal is to better underst…
Sponsor: Rocket Pharmaceuticals Inc. • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:08 UTC
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Can we predict who will die suddenly from heart problems?
Knowledge-focused Recruiting nowThis study follows 1500 people who already have an implantable cardioverter-defibrillator (ICD) to prevent sudden cardiac death. Researchers will track heart function, genetics, and blood markers to find better ways to predict who is at highest risk. The goal is to improve how do…
Sponsor: Johns Hopkins University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:13 UTC
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Heart tissue analysis aims to unlock better diagnosis
Knowledge-focused Recruiting nowThis study looks at heart tissue samples from 216 adults who already need a biopsy as part of their care. Researchers want to find unique molecular patterns in different heart conditions, including after a heart transplant. The goal is to improve how these diseases are diagnosed …
Sponsor: University Hospital, Essen • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:12 UTC