Eyelid disorder

This study tests a new device that delivers a special type of radiation directly into skin tumors. The goal is to see if it can shrink or control the cancer. The study is for adults with certain types of skin cancer, including squamous cell carcinoma and basal cell carcinoma. Par…

This study tests a pill called upadacitinib for people with eyelid dermatitis that hasn't gotten better with standard creams. Ten adults aged 18-70 will take the drug for 12 weeks to see if it reduces redness and irritation. The goal is to find a new option for those who haven't …

This study tests a temporary magnetic device designed to help people with paralytic lagophthalmos—a condition where the eyelid cannot close fully—protect their eyes from dryness, ulcers, and vision loss. The device uses small magnets placed on the eyelids to gently hold them shut…

This study tests an experimental eye drop called GLK-321 in 250 adults with Demodex blepharitis, a condition where tiny mites cause debris at the base of eyelashes. Participants will receive either a low, mid, or high dose of the drug, or a placebo, for 6 weeks. The main goal is …

This study tests a smartphone app that uses artificial intelligence to detect 16 different eye diseases from photos taken with the phone. The AI works entirely on the device, so no internet is needed. Researchers will compare its accuracy to eye doctors and see if non-medical use…

This early study tests a new spring made from surgical stitches to help people with facial nerve palsy close their eyelid. The spring is placed under the skin near the eyelid center, without attaching to bone. Ten adults who cannot blink due to nerve damage will try it, aiming to…

This Phase 3 trial tests whether oxymetazoline eye drops can safely lift droopy eyelids (acquired blepharoptosis) in 234 adults. Participants use the drops twice daily for 14 days. The main goal is to measure how much the eyelid lifts, and patients will also report if they feel i…

This study compares three types of spacer grafts (hard palate, ear cartilage, and a porcine product) used in surgery to fix lower eyelid retraction, a condition where the eyelid pulls down. Researchers will measure eyelid height and track complications in 100 adults who had this …

This study tests whether a lower dose (6%) or a higher dose (8%) of sevoflurane gas works better and causes fewer side effects when putting children aged 1 to 6 years to sleep for minor eye surgery. The main goal is to see which dose leads to less agitation and confusion when the…

This study tests whether a device called IRIDIUM GARZE can help ease eye discomfort in people with blepharitis or blepharoconjunctivitis. About 80 adults in Italy will use the device four times a day for 28 days alongside their usual treatment. The main goal is to see if eye symp…

This study compares red and blue light therapy masks for people with dry eye disease, meibomian gland dysfunction, and blepharitis (eyelid inflammation). Thirty-six participants will receive three light treatments, one week apart, and be followed for one month after the last sess…

This study compares two ways to do upper eyelid surgery: the traditional method and a newer one using a hand-held clamp called Ziplyft. About 50 adults with droopy or extra eyelid skin will have one eye treated with each method, so doctors can directly compare bruising, healing t…

This study looks at how people's immune systems react to infections from parasitic worms, which can cause serious health problems like swelling, blindness, or heart disease. Researchers will evaluate and treat up to 500 participants aged 3 to 100 using standard medical tests and …

This study screens people with eye diseases to see if they can join other research studies at the National Eye Institute. No treatment is given. Participants undergo eye exams, blood tests, and other procedures to diagnose or evaluate their condition. The goal is simply to determ…

This study tests a special camera that takes super-detailed pictures of the back of the eye (the retina). The goal is to see if this technology can find eye diseases earlier than standard methods. Up to 1,000 people aged 12 and older, with or without eye disease, will have their …

This study aims to learn more about eye diseases by observing and providing standard care to up to 1,000 people over 5 years. Participants receive regular eye exams, tests, and treatments as needed. The goal is to better understand how eye diseases progress and are inherited, not…

This study tests whether artificial intelligence can create simple summaries of eye doctor notes that are easier for patients to understand. About 460 English-speaking adults receiving eye care will get either standard notes or notes plus an AI-generated plain language summary. P…

This study will test 10,000 people in Cambodia for 57 different infectious diseases, including dengue, flu, and malaria. Researchers want to understand how these diseases spread and who is at risk. The goal is to give local health authorities the information they need to create b…

This study tests a new 4D microscope-integrated OCT system for the first time in people during eye surgery. Researchers want to see if the system is easy to use, safe, and can clearly show eye structures. Five adults having eye surgery will take part. The goal is to improve imagi…

This study gathers standard eye movement and pupil data from 200 healthy volunteers, children, and people with eye or brain conditions using a VR headset called neos™. The headset shows images and tracks where participants look, how their pupils react, and how their eyes move. Th…

This study tests a new, more comfortable eye camera (WiSLO) designed for children and adults. Researchers want to see if it takes better pictures and is less bothersome than current cameras. About 42 people with or without eye disease will have their eyes photographed with both t…

This study tests two different preparation designs (bevel vs. butt) for Peek endocrowns, which are tooth-colored caps for molars that have had root canals. Researchers will check how precisely each design fits the tooth, using a replica technique and microscope. The goal is to se…