Eye drops could replace surgery for droopy eyelids
NCT ID NCT06514612
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This Phase 3 trial tests whether oxymetazoline eye drops can safely lift droopy eyelids (acquired blepharoptosis) in 234 adults. Participants use the drops twice daily for 14 days. The main goal is to measure how much the eyelid lifts, and patients will also report if they feel improvement. If successful, it may provide a drug alternative to eyelid surgery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
oxymetazoline hydrochloride 0.1% eye drops
What this could lead to
If it works, this could offer a non-surgical option to temporarily lift droopy eyelids, improving vision and appearance.
What could go wrong
This is a Phase 3 trial, but the effect is temporary (requires twice-daily drops) and may not work for everyone. Side effects like eye irritation or redness are possible.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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AOU Federico II
RECRUITINGNaples, 80131, Italy
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AOU di Ferrara, Arcispedale Sant'Anna
RECRUITINGFerrara, 44124, Italy
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Budapest Retina Associates
RECRUITINGBudapest, Hungary
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Budapesti Jahn Ferenc Dél-Pesti Kórház és Rendelőintézet
RECRUITINGBudapest, Hungary
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CHU Rennes - PONTCHAILLOU Service ophtalmologie
RECRUITINGGuillon, 35000, France
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CHU de Saint Etienne - Hôpital NORD Service d'Ophtalmologie
RECRUITINGSaint-Etienne, 42055, France
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Centralny Szpital Kliniczny MSWiA w Warszawie, Oddzial Okulistyki
RECRUITINGWarsaw, 02-507, Poland
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Clinique Ophtalmologique Thiers
RECRUITINGBordeaux, 33100, France
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Complexo Hospitalario Universitario de Santiago
RECRUITINGSantiago de Compostela, 15706, Spain
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Debreceni Egyetem Klinikai Központ
RECRUITINGDebrecen, Hungary
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FaceRestoration Ltd
RECRUITINGLondon, W1G 8QL, United Kingdom
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Fakultni Thomayerova nemocnice
RECRUITINGPrague, 140 59, Czechia
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Fakultni nemocnice Plzeň, Oční oddělení
RECRUITINGPilsen, Czechia
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Gabinet Okulistyczny Prof. Edward Wylegala
RECRUITINGKatowice, 40-594, Poland
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Ganglion Orvosi Központ - Nozologen Kft.
RECRUITINGPécs, Hungary
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Hospital Universitario Miguel Servet
RECRUITINGZaragoza, 50009, Spain
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Hospital Universitario Ramón y Caja
RECRUITINGMadrid, 28034, Spain
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Hospital Universitario Ramón y Cajal
RECRUITINGMadrid, 28034, Spain
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Hospital Universitario Virgen de las Nieves
RECRUITINGGranada, 18014, Spain
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Hôpital Fondation Adolphe de Rothschild
RECRUITINGParis, 75019, France
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Leeds Teaching Hospitals NHS Trust, St James's University Hospital
RECRUITINGLeeds, LS9 7TF, United Kingdom
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Leiden University Center (LUMC)
RECRUITINGLeiden, 2333 ZA, Netherlands
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Miguel Servet University Hospital
RECRUITINGZaragoza, 50009, Spain
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Military Institute of Medecine - National Institute of Research
RECRUITINGWarsaw, 04-141, Poland
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Moorfields Eye Hospital NHS Foundation Trust - Moorfields Eye Hospital
RECRUITINGLondon, EC1V 2PD, United Kingdom
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Oftex.s.r.o, oční klinika
RECRUITINGPardubice, 530 02, Czechia
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Oogziekenhuis Rotterdam
RECRUITINGRotterdam, 3011 BH, Netherlands
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Opal Clinic London Ltd
RECRUITINGLondon, W8 5JN, United Kingdom
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PU A. Gemelli, Università Cattolica del Sacro Cuore
RECRUITINGRoma, 00168, Italy
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Profesorskie Centrum Okulistyki OKULISTYKA OPTIMUM
RECRUITINGGdansk, Poland
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South Tyneside and Sunderland NHS Foundation Trust, Sunderland Eye Infirmary
RECRUITINGSunderland, United Kingdom
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South tyneside & Sunderland NHS Trust, Sunderland Eye Infirmary
RECRUITINGSunderland, SR2 9HP, United Kingdom
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Universitätsmedizin Göttingen; Georg-August-Universität
RECRUITINGGöttingen, 37075, Germany
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Unversitaetsmedizin Goettingen
RECRUITINGGoettigen, 37075, Germany
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Virgen de las Nieves University Hospital
RECRUITINGGranada, 18014, Spain
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Észak-Pesti Centrumkórház - Honvédkórház
RECRUITINGBudapest, Hungary
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