Ptosis

This study tests a new eye drop (STN1013800) for adults with acquired droopy eyelids, a condition that can block vision. About 180 Chinese participants will receive either the eye drop or a placebo once daily for 42 days. The goal is to see if the drops improve vision by lifting …

This Phase 3 trial tests whether oxymetazoline eye drops can safely lift droopy eyelids (acquired blepharoptosis) in 234 adults. Participants use the drops twice daily for 14 days. The main goal is to measure how much the eyelid lifts, and patients will also report if they feel i…

This study compares three types of spacer grafts (hard palate, ear cartilage, and a porcine product) used in surgery to fix lower eyelid retraction, a condition where the eyelid pulls down. Researchers will measure eyelid height and track complications in 100 adults who had this …

This study compares two ways to do upper eyelid surgery: the traditional method and a newer one using a hand-held clamp called Ziplyft. About 50 adults with droopy or extra eyelid skin will have one eye treated with each method, so doctors can directly compare bruising, healing t…

This study compares two surgical methods (anterior vs. posterior white line advancement) to correct droopy eyelids in adults. About 54 participants will be randomly assigned to one technique and followed for 6 months. The goal is to see which approach improves eyelid position, sy…

This study screens people with eye diseases to see if they can join other research studies at the National Eye Institute. No treatment is given. Participants undergo eye exams, blood tests, and other procedures to diagnose or evaluate their condition. The goal is simply to determ…

This study tests a special camera that takes super-detailed pictures of the back of the eye (the retina). The goal is to see if this technology can find eye diseases earlier than standard methods. Up to 1,000 people aged 12 and older, with or without eye disease, will have their …

This study aims to learn more about eye diseases by observing and providing standard care to up to 1,000 people over 5 years. Participants receive regular eye exams, tests, and treatments as needed. The goal is to better understand how eye diseases progress and are inherited, not…

This study follows 73 people with congenital ptosis (droopy eyelids) who are already scheduled for a specific surgery. Researchers will check their vision and ask about their quality of life before surgery and at 1, 3, and 6 months after. The goal is to see if the surgery improve…

This study tests whether artificial intelligence can create simple summaries of eye doctor notes that are easier for patients to understand. About 460 English-speaking adults receiving eye care will get either standard notes or notes plus an AI-generated plain language summary. P…

This study tests a new 4D microscope-integrated OCT system for the first time in people during eye surgery. Researchers want to see if the system is easy to use, safe, and can clearly show eye structures. Five adults having eye surgery will take part. The goal is to improve imagi…

This study gathers standard eye movement and pupil data from 200 healthy volunteers, children, and people with eye or brain conditions using a VR headset called neos™. The headset shows images and tracks where participants look, how their pupils react, and how their eyes move. Th…

This study tests a new, more comfortable eye camera (WiSLO) designed for children and adults. Researchers want to see if it takes better pictures and is less bothersome than current cameras. About 42 people with or without eye disease will have their eyes photographed with both t…

This study will use smartphone recordings of speech, eye movements, and arm fatigue to measure key symptoms of myasthenia gravis, a condition that causes muscle weakness. Researchers will compare 225 participants (both with and without MG) to see if machine learning can accuratel…