Eye adnexa disorder

This study tested an experimental drug called HZN-1116 in 209 people with Sjögren's syndrome, an autoimmune disease causing dry eyes and mouth. The goal was to see if the drug could reduce disease activity and symptoms. The trial was terminated early, so results may not be availa…

This study is for people who finished earlier trials of batoclimab for thyroid eye disease. It has two parts: one watches how long benefits last without treatment, and the other gives batoclimab to see if it helps more patients. The goal is to see if the drug can control eye bulg…

This study tested a drug called secukinumab in adults with active, moderate to severe thyroid eye disease, a condition that causes bulging eyes and discomfort. The trial aimed to see if the drug could reduce eye bulging and inflammation. However, the study was stopped early and o…

This early-phase trial tested an oral drug called K9 (kamuvudine-9) in people with thyroid eye disease, a condition that causes eye bulging and discomfort. The study planned to enroll up to 10 patients but was terminated after only 4 participants. The main goal was to check safet…

This early-stage study tested a new oral drug, ASP5502, for primary Sjögren's syndrome, an autoimmune condition causing dry eyes and mouth. It involved 116 healthy adults and patients to check safety and how the body processes the drug. The study was terminated, but results may g…

This study tested a drug called efgartigimod for people with active, moderate-to-severe thyroid eye disease, a condition that causes bulging eyes and vision problems. About 102 adults took part, receiving either the drug or a placebo. The trial was stopped early because early res…

This study tested a drug called efgartigimod for people with active, moderate-to-severe thyroid eye disease, a condition that causes bulging eyes and vision problems. About 105 adults were randomly assigned to receive either the drug or a placebo as a shot under the skin. The tri…

This study tested whether intense pulsed light (IPL) can help treat chalazion, a common eyelid lump. Only 4 adults with a fresh chalazion were enrolled, and the trial was stopped early. Because of the very small size, we cannot say if IPL works or is safe for this condition.

This study tested a medicated ointment called pimecrolimus 0.3% for people with blepharitis, a condition that causes red, irritated eyelids. The trial planned to include 477 participants aged 2 and older, applying the ointment twice daily to the eyelid margins. The main goal was …

This study tested whether Thealoz Total eye drops can reduce inflammation and improve symptoms in people with chronic dry eye disease. The drops contain hyaluronic acid for lubrication, plus trehalose and NAAGA to fight inflammation. The trial planned to enroll 30 adults with mod…

This study compared two different eye drops (Systane PRO and Refresh Optive Mega-3) to see which one works better for people with dry eye. Twenty adults with moderate dry eye symptoms were enrolled, but the study was stopped early. Participants filled out questionnaires about the…

This study tested a redesigned lacrimal stent, called the Slit Stent II, for people with severe tearing (epiphora) caused by a blocked tear duct. The stent has slits to allow tears to drain while it is still in place after DCR surgery. The trial planned to enroll 5 people to chec…

This study looked at whether a preservative-free eye gel called IRIDIUM® could help relieve dry eye symptoms in people with glaucoma or high eye pressure who were already using multiple eye drop medications. The goal was to see if the gel improved comfort and quality of life. The…

This study compared the TearCare system, a device that applies heat to the eyelids, to standard warm compresses and lid massage for people with dry eye disease. The goal was to see if TearCare is safe and better at improving tear stability and reducing eye discomfort. The study p…

This early-phase trial tested a new eye drop called rhPRG4 in 8 people with Sjögren's syndrome-related dry eye. Participants received either the active drop or a placebo, then switched after 90 minutes. The study measured eye dryness and safety over a single day. Because the tria…

This study aimed to see if certain eye tests could predict which people with dry eye disease would get relief from over-the-counter artificial tears. Researchers planned to enroll 66 adults with dry eye, but the study was terminated early with only 36 participants. Participants u…

This study tested a monthly solution called Tangible Boost that is meant to restore a special coating on contact lenses. The goal was to see if it could improve comfort and vision in people with severe dry eye from Stevens-Johnson syndrome, Sjogren's syndrome, or graft-versus-hos…

This study aimed to find out how many people with Sjögren's dry eye have reduced feeling in their cornea (the clear front part of the eye). Researchers measured corneal sensitivity, tear production, and pain in 103 adults with confirmed Sjögren's syndrome and dry eye. The study w…