Essential tremor

This study tests a precise, non-invasive radiation treatment (frameless virtual cone radiosurgery) to reduce severe tremors in people with essential tremor or Parkinson's disease who cannot have deep brain stimulation. About 40 participants will receive a single focused dose of r…

This study tests a new type of deep brain stimulation for essential tremor that only delivers electricity when a tremor is detected, rather than constantly. The goal is to reduce side effects like slurred speech and walking problems, and make the battery last longer. About 20 adu…

This study tests whether a combination of two sedatives (ketamine and dexmedetomidine, called Ketodex) works better than dexmedetomidine alone for keeping patients comfortable during awake deep brain stimulation surgery. The surgery is used for movement disorders like Parkinson's…

This study explores whether training people with essential vocal tremor to speak with a breathy voice can reduce shakiness and improve their quality of life. Forty participants will learn the technique and rate its ease and effectiveness. Researchers will also measure voice recor…

This study tests a wristband called Cala TWO that uses mild electrical pulses to calm hand tremors in people with essential tremor. Twenty adults scheduled for deep brain stimulation surgery will use the device twice daily for three months. Researchers will measure tremor severit…

This study tests whether a dietary supplement containing aldehyde dehydrogenase (ALDH) enzyme can ease tremors in people with essential tremor. Forty adults will take the supplement twice daily for three months. Researchers will measure changes in tremor severity and daily functi…

This study tests whether a new drug called ulixacaltamide can safely reduce tremors and improve daily activities in adults with essential tremor. About 1,000 participants will receive either the drug or a placebo for up to 12 weeks, then may join a long-term safety study. The goa…

This study was designed to test the safety and feasibility of a focused ultrasound device called Exablate Neuro with a new Echo-Focusing feature for people with treatment-resistant brain disorders like essential tremor or depression. However, the trial was withdrawn before enroll…

This early study tests an adaptive deep brain stimulation (aDBS) system in 2 people with severe, treatment-resistant OCD. The device records brain signals to identify patterns linked to OCD distress and stimulation side effects. The goal is not to treat OCD now, but to gather dat…

This study looks at how different patterns of deep brain stimulation (DBS) affect movement symptoms and brain activity in people with Parkinson's disease, essential tremor, multiple sclerosis, or dystonia. Researchers will test non-regular stimulation patterns to find ways to mak…

This study was designed to find out if deep brain stimulation (DBS) in the thalamus, used to treat essential or dystonic tremor, also changes breathing. Researchers planned to measure breath-holding and peak airflow in a small group of patients before and after DBS surgery. Howev…

This study at Mayo Clinic will see if an Apple Watch can measure how well deep brain stimulation (DBS) controls essential tremor throughout the day. Fifty patients with DBS implants will wear the watch and perform simple tasks while the watch collects movement and heart data. The…

This observational study aims to better understand essential tremor, a common movement disorder. Researchers will follow 100 participants over about 5 years, using clinical exams, brain imaging, and lab tests to identify different disease subtypes and markers of progression. The …