Ectopic ACTH secretion syndrome
MONDO:0043472A syndrome characterized by abnormal secretion of adrenocorticotrophic hormone in conjunction with neoplastic growth occurring anywhere in the body. The most common associations are tumors of the bronchus (oat cell or carcinoid), thymic tumors (epithelial or carcinoid), and pancreatic endocrine tumor. (DeVita et al. Cancer, p 1364. 4th edition. Lippincott)
Also known as: ectopic ACTH secretion, ectopic ACTH secretion syndrome, ectopic ACTH syndrome, hypercortisolism due to nonpituitary tumor, hypercortisolism due to nonpituitary tumour, ACTH syndromes, ectopic, ectopic ACTH secretion causing Cushing's syndrome, ectopic ACTH syndromes
20 clinical trials for this condition and its sub-types.
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New drug aims to tackle diabetes by targeting stress hormone
Disease control Recruiting nowThis phase 2 trial tests clofutriben, a drug that lowers cortisol, in 1500 adults with hard-to-control type 2 diabetes and signs of high cortisol. Participants receive either clofutriben or a placebo daily for 24 weeks. The study measures changes in blood sugar and cortisol level…
Phase: PHASE2 • Sponsor: Sparrow Pharmaceuticals • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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New pill could tame hormone disorder Cushing's syndrome
Disease control Recruiting nowThis early-stage study tests an experimental pill called CRN04894 in 18 adults with Cushing's syndrome caused by too much ACTH hormone. The drug works by blocking the receptor that ACTH acts on, aiming to lower cortisol levels and control the disease. The main goals are to check …
Phase: PHASE1, PHASE2 • Sponsor: Crinetics Pharmaceuticals Inc. • Aim: Disease control
Last updated Jun 27, 2026 13:02 UTC
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Can a diabetes drug replace surgery for a rare hormone disorder?
Disease control Recruiting nowThis study looks at two treatments for mild autonomous cortisol secretion (MACS), a condition where the body makes too much cortisol. Researchers want to see if removing the adrenal gland (surgery) or taking semaglutide (a weight-loss drug) better improves insulin resistance and …
Phase: NA • Sponsor: University of Texas Southwestern Medical Center • Aim: Disease control
Last updated Jun 27, 2026 12:00 UTC
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New drug targets hidden hormone problem to boost heart and bone health
Disease control Recruiting nowThis study tests whether the drug Isturisa can improve blood sugar, cholesterol, blood pressure, weight, and bone strength in people with mild autonomous cortisol secretion (MACS), a condition where the body makes too much cortisol. Ten adults with MACS will take Isturisa for two…
Phase: PHASE4 • Sponsor: Johns Hopkins University • Aim: Disease control
Last updated Jun 27, 2026 09:11 UTC
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New pill aims to tame hidden cortisol problem
Disease control Recruiting nowThis study tests a low dose of the drug osilodrostat in 15 adults with mild autonomous cortisol secretion (MACS), a condition where the body makes too much cortisol. The goal is to see if the drug is safe and can help balance cortisol levels. Participants will take the pill and b…
Phase: PHASE2 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated Jun 27, 2026 09:04 UTC
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Can a simple blood test catch Cushing's earlier?
Diagnosis Recruiting nowThis study aims to improve how doctors diagnose Cushing's syndrome, a condition caused by too much cortisol. Researchers will test the accuracy of the desmopressin stimulation test in 140 people aged 18-70 who have or may have Cushing's, plus healthy volunteers. Participants will…
Phase: PHASE2 • Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) • Aim: Diagnosis
Last updated Aug 12, 2026 00:00 UTC
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NIH launches study to uncover genetic roots of Hormone-Driven high blood pressure in black communities
Knowledge-focused Recruiting nowThis study aims to find the genetic causes of primary aldosteronism, a condition where adrenal tumors cause high blood pressure, in Black individuals. Researchers will enroll 1150 participants, including those with difficult-to-control blood pressure or known primary aldosteronis…
Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) • Aim: Knowledge-focused
Last updated Aug 06, 2026 00:00 UTC
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New imaging tracer could shed light on adrenal cholesterol
Knowledge-focused Recruiting nowThis study tests a special radioactive tracer called [18F]FNP-59 to see if it can safely and clearly show cholesterol activity in the adrenal gland using PET scans. About 24 people will take part, including healthy volunteers and those with known adrenal problems. The goal is to …
Phase: EARLY_PHASE1 • Sponsor: Benjamin Viglianti • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:02 UTC