Ectopic ACTH secretion syndrome
MONDO:0043472A syndrome characterized by abnormal secretion of adrenocorticotrophic hormone in conjunction with neoplastic growth occurring anywhere in the body. The most common associations are tumors of the bronchus (oat cell or carcinoid), thymic tumors (epithelial or carcinoid), and pancreatic endocrine tumor. (DeVita et al. Cancer, p 1364. 4th edition. Lippincott)
Also known as: ectopic ACTH secretion, ectopic ACTH secretion syndrome, ectopic ACTH syndrome, hypercortisolism due to nonpituitary tumor, hypercortisolism due to nonpituitary tumour, ACTH syndromes, ectopic, ectopic ACTH secretion causing Cushing's syndrome, ectopic ACTH syndromes
25 clinical trials for this condition and its sub-types.
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Could a drug tame excess cortisol in a common hormone disorder?
Disease control Not yet recruitingThis study tests whether the drug metyrapone can safely lower cortisol levels in people with mild autonomous cortisol secretion (MACS), a condition where the adrenal glands produce too much cortisol. Participants will receive either metyrapone or a placebo for a short period, and…
Phase: PHASE2 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated Jul 01, 2026 00:00 UTC
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New hope for Cushing's patients with high blood pressure
Disease control Not yet recruitingThis study tests a drug called osilodrostat in 63 adults with Cushing's syndrome and high blood pressure. The goal is to see if it can safely lower blood pressure by reducing cortisol levels. Participants will take the drug or a placebo for 30 weeks, with doses adjusted based on …
Phase: PHASE4 • Sponsor: RECORDATI GROUP • Aim: Disease control
Last updated Jun 27, 2026 08:03 UTC
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Tiny trial to see if a dye helps adrenal surgery
Knowledge-focused Not yet recruitingThis study will look at 12 people having surgery to remove an adrenal gland (adrenalectomy) using robotic or laparoscopic methods. Some surgeries will use a green dye called Indocyanine Green (ICG) to help the surgeon see better, while others will not. The main goal is to track c…
Sponsor: University of Roma La Sapienza • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:32 UTC