Disorder of acid-base balance

This study compares two drugs, sodium bicarbonate and THAM, for treating metabolic acidosis in patients after heart surgery. About 250 adults who develop acidosis after using a heart-lung machine will be randomly assigned to receive one of the two drugs. The main goal is to see i…

This study tests whether giving sodium bicarbonate (baking soda) intravenously can reduce major kidney problems or death in critically ill patients with metabolic acidosis and acute kidney injury. About 660 adults in intensive care will receive either sodium bicarbonate or a stan…

This study tests whether taking sodium bicarbonate (baking soda) tablets twice a day for a month can prevent blood pressure from rising during dialysis. It involves 40 chronic hemodialysis patients who already experience blood pressure spikes during treatment. The goal is to see …

This study looks at 100 adults who needed a breathing machine after a heart attack or cardiac arrest. Researchers want to see how often acid-base problems happen and compare the settings doctors used with those suggested by a computer algorithm. The goal is to improve future care…

This study watches how carbon dioxide gas, used to inflate the belly during laparoscopic weight-loss surgery, changes blood bicarbonate levels. Researchers will track 85 adults having sleeve gastrectomy or gastric bypass to see if these changes relate to how long the gas is used …

This 10-year observational study will follow 10,000 adults with diabetes, metabolic disorders, and related conditions like high blood pressure and fatty liver disease. Researchers will collect routine medical data to identify markers of disease severity and activity. The goal is …