Degenerative myopia
MONDO:0001383Excessive axial myopia associated with complications (especially posterior staphyloma and choroidal neovascularization) that can lead to blindness.
Also known as: progressive high (degenerative) myopia
43 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsBroader categories
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Can red light save your sight? new trial for severe nearsightedness
Disease control Recruiting nowThis study tests if a special red light device can slow down damage to the back of the eye in people with severe nearsightedness (pathologic myopia). About 158 adults will use the device or a fake one for 3 minutes, twice a day, 5 days a week for a year. Researchers will check if…
Phase: NA • Sponsor: Shanghai Eye Disease Prevention and Treatment Center • Aim: Disease control
Last updated Jun 27, 2026 12:33 UTC
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Probiotic MR-61: a gut feeling against myopia?
Disease control Recruiting nowThis study tests whether a probiotic called MR-61 can help slow the worsening of nearsightedness (myopia) in children and teens aged 3 to 18. Participants will take either the probiotic or a placebo daily for a period, and researchers will measure changes in their vision and eye …
Phase: PHASE2 • Sponsor: Second Affiliated Hospital of Nanchang University • Aim: Disease control
Last updated Jun 27, 2026 08:06 UTC
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AI boosts cataract surgery precision for severely nearsighted patients
Diagnosis Recruiting nowThis study will enroll 500,000 people with high myopia and cataracts to develop an artificial intelligence model that helps doctors calculate the correct lens power and grade cataracts more accurately. The goal is to improve vision outcomes and reduce complications after surgery.…
Sponsor: Shanghai High Myopia Study Group • Aim: Diagnosis
Last updated Jun 27, 2026 12:32 UTC
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AI eye scanner could predict blindness risk in nearsighted patients
Diagnosis Recruiting nowThis study is testing whether artificial intelligence can analyze eye images to better detect and predict vision-threatening changes in people with high myopia (severe nearsightedness). Researchers will collect eye scans from 1,000 patients and use AI to identify a condition call…
Sponsor: Shanghai 10th People's Hospital • Aim: Diagnosis
Last updated Jun 27, 2026 09:07 UTC
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New contact lenses put to the test: are they safe for daily wear?
Symptom relief Recruiting nowThis study is testing a new type of daily disposable contact lens called UNICON. It will involve 35 adults who already wear soft contact lenses. Participants will wear the test lenses for up to 13 weeks to see if they are safe and comfortable for correcting nearsightedness.
Phase: NA • Sponsor: Unicon Optical Co. Ltd. • Aim: Symptom relief
Last updated Jun 27, 2026 08:12 UTC
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European study seeks clues to mysterious eye bulge in severe myopia
Knowledge-focused Recruiting nowThis study looks at 200 highly myopic adults in France, the Netherlands, and Spain to understand why some develop a condition called posterior staphyloma, where the back of the eye bulges outward. Researchers will analyze blood samples and eye images to find genetic and molecular…
Phase: NA • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Aug 09, 2026 00:00 UTC
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New glasses for nearsighted kids: will they wear them?
Knowledge-focused Recruiting nowThis pilot study is testing how well children aged 6 to 16 adapt to Essilor Stellest myopia-control spectacle lenses. The goal is to see if kids find them comfortable and easy to wear in real life, which is important for long-term use. Fifty children with progressive myopia will …
Sponsor: Nantes University Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:03 UTC
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Massive eye database aims to unlock secrets of blinding diseases
Knowledge-focused Recruiting nowThis study is creating a large database of eye measurements from 3,000 people with inflammatory eye diseases like diabetic retinopathy and age-related macular degeneration. Researchers will use advanced imaging to collect detailed information from both the front and back of the e…
Sponsor: Dan Chen • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:02 UTC
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New eye models could make LASIK safer and more predictable
Knowledge-focused Recruiting nowThis study is developing imaging and computer simulation tools to predict how a person's cornea (the clear front part of the eye) will change after treatments like crosslinking for keratoconus or LASIK for vision correction. Researchers will take detailed images of the eyes of 60…
Sponsor: The Cleveland Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:00 UTC
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60,000 eyes tracked: scientists hunt genes behind cataract outcomes
Knowledge-focused Recruiting nowThis study follows 60,000 people with cataracts, including those with high myopia (severe nearsightedness), to see how their vision changes after cataract surgery. Researchers will also look at genetic and environmental factors that might affect cataract development and surgical …
Sponsor: Shanghai High Myopia Study Group • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:32 UTC