Corneal disorder
MONDO:0000942A non-neoplastic or neoplastic disorder that affects the cornea. Representative examples include keratitis, bullous keratopathy, and squamous cell carcinoma.
Also known as: cornea disease, cornea disease or disorder, corneal disease, corneal disorder, disease of cornea, disease or disorder of cornea, disorder of cornea
465 clinical trials for this condition and its sub-types, 46 tagged with Corneal disorder itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
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Sub-types of Corneal disorder
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Keratitis 6 trials · 298 incl. sub-types
11 sub-types
- Keratoconjunctivitis 1 trial · 260 incl. sub-types Sub-types →
- Corneal infection 6 trials · 22 incl. sub-types Sub-types →
- Corneal ulcer 16 trials · 18 incl. sub-types Sub-types →
- Corneal neovascularization 5 trials Sub-types →
- Deep keratitis 0 trials · 1 incl. sub-types Sub-types →
- Autosomal dominant keratitis 0 trials
- Filamentary keratitis 0 trials
- Macular keratitis 0 trials
- Photokeratitis 0 trials
- Scleroperikeratitis 0 trials
- Superficial keratitis 0 trials Sub-types →
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Keratoconus 61 trials
11 sub-types
- Keratoconus, stable condition 2 trials
- Acute hydrops keratoconus 0 trials
- Keratoconus 1 0 trials
- Keratoconus 2 0 trials
- Keratoconus 3 0 trials
- Keratoconus 4 0 trials
- Keratoconus 5 0 trials
- Keratoconus 6 0 trials
- Keratoconus 7 0 trials
- Keratoconus 8 0 trials
- Keratoconus 9 0 trials
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Corneal dystrophy 6 trials · 60 incl. sub-types
13 sub-types
- Corneal endothelial dystrophy 5 trials · 36 incl. sub-types Sub-types →
- Posterior corneal dystrophy 0 trials · 34 incl. sub-types Sub-types →
- Stromal corneal dystrophy 2 trials · 16 incl. sub-types Sub-types →
- Superficial corneal dystrophy 0 trials · 7 incl. sub-types Sub-types →
- Epithelial-stromal TGFBI dystrophy 1 trial · 3 incl. sub-types Sub-types →
- Chandler syndrome 2 trials
- Epithelial and subepithelial corneal dystrophy 0 trials · 2 incl. sub-types Sub-types →
- Finnish type amyloidosis 0 trials
- Judge Misch wright syndrome 0 trials
- Autosomal dominant keratitis 0 trials
- Band keratopathy 0 trials
- Corneal dystrophy, punctiform and polychromatic pre-descemet 0 trials
- Macular dystrophy, fenestrated sheen type 0 trials
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Corneal edema 17 trials · 24 incl. sub-types
4 sub-types
- Bullous keratopathy 12 trials
- Secondary corneal edema 6 trials
- Contact lens corneal edema 0 trials
- Idiopathic corneal edema 0 trials
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Cornea neoplasm 0 trials · 17 incl. sub-types
3 sub-types
- Benign neoplasm of cornea 0 trials · 17 incl. sub-types Sub-types →
- Cornea cancer 0 trials Sub-types →
- Corneal intraepithelial neoplasm 0 trials
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Keratopathy 3 trials · 15 incl. sub-types
2 sub-types
- Bullous keratopathy 12 trials
- Band keratopathy 0 trials
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Corneal ectasia 11 trials
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Limbal stem cell deficiency 10 trials
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Pellucid marginal degeneration 4 trials
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Corneal degeneration 1 trial · 2 incl. sub-types
5 sub-types
- Arcus senilis 1 trial
- Band keratopathy 0 trials
- Nodular degeneration of cornea 0 trials
- Peripheral degeneration of cornea 0 trials
- Phthisical cornea 0 trials
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Cornea plana 0 trials · 2 incl. sub-types
2 sub-types
- Cornea plana 1, autosomal dominant 2 trials
- Cornea plana 2 0 trials
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Peters anomaly 1 trial
2 sub-types
- Peters anomaly-cataract syndrome 0 trials
- Von Hippel anomaly 0 trials
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Pseudopterygium 1 trial
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Arnold stickler bourne syndrome 0 trials
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Bowman's membrane folds or rupture 0 trials
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Terrien marginal degeneration 0 trials
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X-linked corneal dermoid 0 trials
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Brittle cornea syndrome 0 trials
2 sub-types
- Brittle cornea syndrome 1 0 trials
- Brittle cornea syndrome 2 0 trials
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Corneal argyrosis 0 trials
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Corneal deposit 0 trials
3 sub-types
- Anterior corneal pigmentation 0 trials
- Posterior corneal pigmentation 0 trials
- Stromal corneal pigmentation 0 trials
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Corneal staphyloma 0 trials
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Megalocornea 0 trials
1 sub-type
- Isolated congenital megalocornea 0 trials
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Sclerocornea 0 trials
2 sub-types
- Anterior segment dysgenesis 7 0 trials
- Sclerocornea, autosomal dominant 0 trials
Most studied deeper sub-types
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Eye drops could stop a rare cause of blindness
Disease control CompletedThis early-stage study tested whether infliximab, a drug usually given through a vein, can be safely used as eye drops for sterile corneal melt. This condition causes the clear front part of the eye to thin, which can lead to blindness. Seven adults with this condition received t…
Phase 1 • Sponsor: Centre hospitalier de l'Université de Montréal (CHUM) • Aim: Disease control
Last updated Jun 27, 2026 12:24 UTC
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New eye drop shows promise for rare corneal disease
Disease control CompletedThis study tested an eye drop called OXERVATE in 37 adults with stage 1 neurotrophic keratitis, a condition where the cornea loses feeling and doesn't heal properly. The treatment was given for 8 weeks, and patients were followed for 24 weeks to see if the cornea healed safely. T…
Phase 4 • Sponsor: Dompé Farmaceutici S.p.A • Aim: Disease control
Last updated Jun 27, 2026 07:57 UTC
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Eye injection shows promise against fungal ulcers
Disease control CompletedThis study tested whether adding an injection of the antifungal drug voriconazole into the eye could improve treatment for fungal corneal ulcers. 70 people with moderate to severe infections received either standard antifungal drops alone or drops plus three injections over 10 da…
Phase 3 • Sponsor: University of California, San Francisco • Aim: Disease control
Last updated Jun 27, 2026 07:52 UTC
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New eye gel passes safety test in cataract and glaucoma surgeries
Disease control CompletedThis study tested a gel called MINIVISC® PLUS, used during eye surgeries like cataract removal and glaucoma surgery to protect delicate tissues and keep the eye stable. Researchers checked if the gel was safe and worked well in 134 patients. The main focus was on eye pressure aft…
Sponsor: Bohus Biotech AB • Aim: Disease control
Last updated Jun 26, 2026 19:01 UTC
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New eye scanner could sharpen diagnosis of glaucoma and retina diseases
Diagnosis CompletedThis study is testing a new eye imaging device called the VG200D, which uses advanced technology to take detailed pictures of the eye. Researchers want to see if it works as well as a standard device for measuring parts of the eye in people with glaucoma, retina problems, corneal…
Sponsor: Intalight, Inc • Aim: Diagnosis
Last updated Jul 31, 2026 00:00 UTC
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Insulin eye drops put to the test for faster corneal healing
Symptom relief CompletedResearchers are testing whether insulin eye drops help the cornea heal faster and reduce pain after corneal collagen cross-linking, a procedure used to treat keratoconus. In this paired-eye study, each participant receives insulin drops in one eye and standard drops in the other,…
Phase 2/3 • Sponsor: Cairo University • Aim: Symptom relief
Last updated Sep 12, 2026 00:00 UTC
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Tiny drops, big savings: new study tests smaller eye drops for numbing
Symptom relief CompletedThis study tested whether a special adaptor that makes smaller eye drops works as well as standard drops for numbing the eye. 56 adults received numbing drops in each eye—one with the standard bottle and the other with the Nanodropper adaptor. Researchers measured how numb each e…
Phase 4 • Sponsor: Columbia University • Aim: Symptom relief
Last updated Jun 27, 2026 09:05 UTC
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Stem cell eye drops show promise for Hard-to-Treat corneal damage
Symptom relief CompletedThis early-stage study tested the safety of eye drops made from stem cell secretions in 9 adults with chronic corneal surface disease that did not improve with standard treatments. The drops were given in increasing doses to find the safest amount. Researchers checked for side ef…
Early phase 1 • Sponsor: University of Illinois at Chicago • Aim: Symptom relief
Last updated Jun 27, 2026 09:00 UTC
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Birth control pills could reshape your cornea, study suggests
Knowledge-focused CompletedThis study looks at whether taking combined oral contraceptive pills changes the shape and optical quality of the cornea — the clear front part of the eye. Researchers will measure corneal curvature and irregularities in women aged 18-40 before they start the pill and again after…
Sponsor: Elshimaa A.Mateen • Aim: Knowledge-focused
Last updated Jul 11, 2026 00:00 UTC
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New registry aims to improve corneal transplants with AI
Knowledge-focused CompletedThis study created a nationwide registry to track long-term results of corneal surgeries and diseases. Researchers collected images and data from 19 participants to help understand what makes corneal transplants successful. The goal is to use this information to develop AI that c…
Sponsor: Nitin Vaswani • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:06 UTC
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AI eye chatbot matches doctors in taking patient history
Knowledge-focused CompletedThis study tested whether a large language model (like ChatGPT) could collect medical history and suggest eye tests as well as doctors do. 172 patients with non-emergency eye problems took part. The AI's performance was compared to standard care, with senior specialists checking …
Sponsor: Zhongshan Ophthalmic Center, Sun Yat-sen University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:10 UTC