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Insulin eye drops put to the test for faster corneal healing

NCT ID NCT07812129

Symptom relief Sponsor: Cairo University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 10, 2026 · Last updated Sep 11, 2026 · Updated 1 time

Summary

Researchers are testing whether insulin eye drops help the cornea heal faster and reduce pain after corneal collagen cross-linking, a procedure used to treat keratoconus. In this paired-eye study, each participant receives insulin drops in one eye and standard drops in the other, so each person acts as their own control. Doctors measure the size of the corneal wound and ask about pain at several visits until the eye surface heals. The trial includes 24 adults with progressive keratoconus scheduled for cross-linking in both eyes.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
insulin eye drops
What this could lead to
If insulin eye drops speed corneal healing, they could become a simple add-on to standard care after cross-linking and possibly other corneal injuries.
What could go wrong
This is a small, single-center study of 24 people with keratoconus, so results may not apply to other eye conditions or patients. Insulin eye drops can irritate the eye, and any benefit may be too small to matter in practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2/3

Runs two stages together: whether the treatment works, then large-scale confirmation.

Participants

24 people

The number who actually took part.

Started

Nov 2023

Finished

May 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: \- Patients above 18 years old diagnosed with bilateral progressive Keratoconus with central corneal thickness more than 400 microns at thinnest location. Exclusion Criteria: * Patients with signs of infectious keratitis (bacterial, fungal, protozoal or mixed poly-microbial). * Patients with a history of herpetic keratitis or having diminished corneal sensation. * Patients with severe dry eye, apical corneal scarring, hydrops, a history of corneal surgery, or ophthalmic disease other than keratoconus. * Single eyed patients. * Patients on systemic treatment involving steroids or immune-compromised patients. * Patients who cannot be monitored with frequent visits as required in the study protocol. * Pregnant and nursing females.

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Conditions

The condition(s) this trial relates to.

corneal disorder keratoconus Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Corneal epithelial wound healing Post operative pain

Contacts and locations

Locations

  • Cairo University Faculty of Medicine (Kasr Al Ainy)

    Cairo, Al-Manial, 11956, Egypt

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