Chronic intestinal failure

This study tests an injectable form of choline, a nutrient often missing in people with intestinal failure who rely on IV nutrition. The goal is to see if it can safely raise choline levels and reduce liver injury. About 129 adolescents and adults will receive either a low or hig…

This study tests if a 4% tetrasodium EDTA solution is better than the standard heparin lock at preventing central line blockages in children with intestinal failure who need long-term nutrition through a vein. About 124 children from multiple hospitals will take part. The goal is…

This study tests whether semaglutide, a drug used for diabetes, can improve intestinal barrier function in adults with short bowel syndrome who need intravenous nutrition. Twenty participants will receive either semaglutide or a placebo for 28 days. Researchers will measure blood…

This early-phase trial is testing whether giving intestinal transplant patients stem cells from their organ donor can safely allow them to take less immunosuppression medication. The goal is to reduce the high risk of infections and cancers caused by these drugs. Six participants…

This study tests if transplanting a piece of abdominal wall (the muscle and tissue covering the belly) can safely repair large defects, like hernias or injuries. It can be done alone or with another organ transplant, like a kidney or liver. Only 5 adults aged 18-65 are being enro…

This study follows 120 children with intestinal failure who have stopped receiving nutrition through an IV (parenteral nutrition) for at least a year. Researchers want to see if these children grow up healthy by checking for poor growth, vitamin shortages, weak bones, unusual bod…

This study aims to collect medical data and biological samples (blood, urine, stool, and tissue) from up to 4,000 adults with known or suspected gastrointestinal diseases. Participants receive standard medical care at the NIH, and any extra samples or leftover tissue from procedu…

This study looks at 20 people who receive nutrition through a tube at home (parenteral nutrition) at night. Researchers want to see if switching to daytime feeding or adding a small dose of melatonin can fix disrupted body clocks, improve sleep, and boost quality of life for both…

This study looks at how much protein people with chronic intestinal failure need when they receive nutrition through a vein at home. The goal is to better understand their protein use and improve personalized nutrition mixtures. Researchers will also study gut bacteria and fatty …

This study tests whether an artificial intelligence (AI) tool can help doctors order total parenteral nutrition (TPN) for babies in the neonatal intensive care unit (NICU). Premature babies often cannot eat by mouth and need nutrition delivered through an IV. The AI suggests TPN …