Chronic intestinal failure
MONDO:0017418Chronic intestinal failure (CIF) is a chronic type of intestinal failure characterized by a nonfunctioning small bowel (that may be reversible or irreversal) where the body is unable to maintain energy and nutritional needs through absorption of food or nutrients via the intestinal tract (despite being metabolically stable) and which therefore necessitates long-term parenteral feeding. CIF may be the result of congenital digestive diseases (such as gastroschisis, atresia of small intestine), short bowel syndrome, intra-abdominal or pelvic cancer, or progressive and devastating gastrointestinal or systemic benign diseases (such as Crohn disease).
Also known as: CIF
23 clinical trials for this condition and its sub-types.
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Could a common diabetes drug help heal the gut in short bowel syndrome?
Disease control CompletedThis study tests whether semaglutide, a drug used for diabetes, can improve intestinal barrier function in adults with short bowel syndrome who need intravenous nutrition. Twenty participants will receive either semaglutide or a placebo for 28 days. Researchers will measure blood…
Sponsor: Jinling Hospital, China • Aim: Disease control
Last updated Jul 16, 2026 00:00 UTC
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Baking soda in catheters may cut infections in kids with gut failure
Disease control CompletedThis small study tested whether filling central catheters with sodium bicarbonate (baking soda) when not in use could prevent infections in children with intestinal failure. Six children participated, and the study looked at how many catheter-related bloodstream infections occurr…
Phase 2 • Sponsor: Riad Rahhal • Aim: Disease control
Last updated Jun 27, 2026 12:39 UTC
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New device aims to cut IV nutrition needs for intestinal failure patients
Disease control CompletedThis study tested a device that collects waste from an opening in the belly and returns it to the lower intestine. The goal was to see if it could reduce the amount of IV nutrition needed by at least half. 44 adults with intestinal failure and a fistula or double stoma took part.…
Sponsor: The Insides Company • Aim: Disease control
Last updated Jun 27, 2026 08:02 UTC
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Can Omega-3s in IV food help gut failure patients?
Disease control CompletedThis study tested whether adding omega-3 fatty acids to intravenous (IV) nutrition could reduce oxidative stress in 20 adults with intestinal failure, a condition where the gut cannot absorb enough nutrients. Participants received either standard IV nutrition or IV nutrition with…
Sponsor: Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran • Aim: Disease control
Last updated Jun 27, 2026 07:51 UTC
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Video training may cut infection risk for home nutrition patients
Knowledge-focused CompletedThis study tested whether an educational video on safe catheter care could reduce bloodstream infections in adults starting home parenteral nutrition for the first time. Twenty-five participants received the video training alongside standard care. Researchers tracked infection ra…
Sponsor: University of Chicago • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:31 UTC
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Tiny sensor reveals hidden blood sugar swings in fragile infants
Knowledge-focused CompletedThis study looked at how blood sugar levels change in hospitalized babies with intestinal failure when their intravenous nutrition is given in cycles instead of continuously. Nine infants wore a small sensor on their thigh that measured glucose every 5 minutes for up to 30 days. …
Sponsor: Boston Children's Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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Just right: study tests drink strength for ileostomy patients
Knowledge-focused CompletedThis study tested how the concentration (osmolality) of oral drinks affects the amount of output from an ileostomy over 6 hours. Fourteen adults with an ileostomy took part in a crossover trial where they tried different drink concentrations. The goal was to find the optimal bala…
Sponsor: University of Aarhus • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:58 UTC
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New study reveals key infection risks for intestinal failure patients
Knowledge-focused CompletedThis study looked at 321 hospitalized patients with intestinal failure to find out what makes them more likely to get a bloodstream infection from their catheter. Researchers identified specific risk factors for different types of intestinal failure. The goal is to help doctors p…
Sponsor: Jinling Hospital, China • Aim: Knowledge-focused
Last updated Jun 26, 2026 17:14 UTC