Can donor stem cells help intestinal transplant patients ditch heavy meds?
NCT ID NCT04804891
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial is testing whether giving intestinal transplant patients stem cells from their organ donor can safely allow them to take less immunosuppression medication. The goal is to reduce the high risk of infections and cancers caused by these drugs. Six participants will receive a single infusion of donor bone marrow stem cells, and researchers will monitor for side effects like graft-versus-host disease and how well the transplant survives.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
donor bone marrow stem cells (CD34+ cells)
What this could lead to
If successful, this approach could allow intestinal transplant patients to take less immunosuppression medication, reducing their risk of serious infections and certain cancers while still preventing organ rejection.
What could go wrong
This is a very early, small phase 1 trial with only 6 participants, so results may not apply broadly. There is a risk of graft-versus-host disease (GVHD), where donor cells attack the recipient's body, and the strategy may not effectively reduce immunosuppression.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Columbia University Irving Medical Center/NYP
RECRUITINGNew York, New York, 10032, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••