Chronic graft versus host disease
MONDO:0020547Chronic graft versus host disease (GVHD) is a complication that can occur after a stem cell or bone marrow transplant in which the newly transplanted donor cells attack the transplant recipient's body. Symptoms may include skin rash, mouth sores, dry eyes, liver inflammation, development of scar tissue in the skin and joints, and damage to the lungs. The exact cause of chronic GVHD is unknown.It likely results from a complex immune-mediated interaction between the donor and recipient cells.Chronic GVHD is treated with prednisone or other similar anti-inflammatory or immunosuppressive medications.
Also known as: GVHD, chronic, graft versus host disease, chronic, chronic GVHD
115 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsBroader categories
-
Rollover study offers continued itacitinib access for chronic disease patients
Disease control TerminatedThis study provides continued access to itacitinib for 18 patients who were already benefiting from the drug in earlier trials. Participants have myelofibrosis, chronic graft-versus-host disease, or bronchiolitis obliterans after lung transplant. They continue their same dose as …
Phase: PHASE2 • Sponsor: Incyte Corporation • Aim: Disease control
Last updated Jun 28, 2026 00:00 UTC
-
Promising GVHD prevention trial halted early – too few patients to draw conclusions
Disease control TerminatedThis phase II trial tested whether the drug ibrutinib could prevent chronic graft-versus-host disease (GVHD) in adults who had received a donor stem cell transplant. Only 2 people enrolled before the study was terminated early. Because of the very small number of participants, no…
Phase: PHASE2 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated Jun 27, 2026 12:37 UTC
-
Steroid-Free hope? early trial of ruxolitinib for young GVHD patients ends prematurely
Disease control TerminatedThis pilot study tested whether the drug ruxolitinib could be used as the first treatment for chronic graft-versus-host disease (cGVHD) in children and young adults, instead of the usual high-dose steroids. The goal was to see if it could control the disease while avoiding steroi…
Phase: PHASE1 • Sponsor: Children's Hospital Medical Center, Cincinnati • Aim: Disease control
Last updated Jun 27, 2026 09:07 UTC
-
Experimental eye drops for GVHD dry eye show early promise but trial stops short
Disease control TerminatedThis study tested a new eye drop (rhPRG4) in 3 adults with moderate to severe dry eye from chronic graft-versus-host disease (GVHD), a complication of bone marrow transplants. The goal was to see if the drops safely improve dryness and eye surface damage. The trial was terminated…
Phase: PHASE1, PHASE2 • Sponsor: Lubris Bio Pty Ltd • Aim: Disease control
Last updated Jun 27, 2026 08:13 UTC
-
UV light zaps mouth sores in transplant patients?
Disease control TerminatedThis study tested whether shining a special UV light inside the mouth could help people with painful mouth sores caused by graft-versus-host disease after a stem cell transplant. Only 11 people took part, and the study was stopped early. The goal was to see if the light treatment…
Phase: PHASE2 • Sponsor: Brigham and Women's Hospital • Aim: Disease control
Last updated Jun 27, 2026 08:05 UTC
-
Promising drug for Post-Transplant blood issues falls short in early trial
Disease control TerminatedThis study tested a drug called fostamatinib to help people whose blood cell counts drop after a stem cell transplant. The goal was to see if the drug could raise red blood cells or platelets without needing transfusions. The trial was stopped early after enrolling only one perso…
Phase: PHASE2 • Sponsor: National Heart, Lung, and Blood Institute (NHLBI) • Aim: Disease control
Last updated Jun 27, 2026 08:01 UTC
-
New drug combo for transplant complication shows promise but study halted
Disease control TerminatedThis study tested whether adding itacitinib (an anti-inflammatory drug) to standard steroid treatment could help people with moderate to severe chronic graft-versus-host disease (cGVHD), a complication after stem cell transplants. The trial enrolled 155 participants but was termi…
Phase: PHASE2, PHASE3 • Sponsor: Incyte Corporation • Aim: Disease control
Last updated Jun 27, 2026 07:55 UTC
-
Could a cheap arthritis drug replace steroids for transplant complications?
Disease control TerminatedThis study tested leflunomide, a drug used for rheumatoid arthritis, as a first-line treatment for musculoskeletal graft-versus-host disease (GVHD), a complication of bone marrow transplants where donor cells attack the patient's muscles and joints. The goal was to see if lefluno…
Phase: PHASE2 • Sponsor: Tata Memorial Centre • Aim: Disease control
Last updated Jun 26, 2026 15:35 UTC
-
New Light-Based scanner aims to spot inflammation without needles
Diagnosis TerminatedThis study tested a new imaging tool called multispectral optoacoustic tomography (MSOT) to see if it could safely detect inflammation in people with graft-versus-host disease, Crohn's disease, or colitis. The device uses light and sound to create images of inflamed areas. The tr…
Phase: NA • Sponsor: University of Oklahoma • Aim: Diagnosis
Last updated Jun 27, 2026 13:00 UTC
-
Light therapy study sheds light on immune changes in transplant complication
Knowledge-focused TerminatedThis study looked at how extracorporeal photopheresis (ECP) — a treatment that uses light to modify a patient's own blood cells — affects the immune system in people with chronic graft-versus-host disease (cGVHD), a complication after a stem cell transplant. Only 8 people were en…
Sponsor: University Hospital, Lille • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:05 UTC