Chronic asthma

This study tests a new drug, linvemastat, for adults with moderate-to-severe asthma that is not fully controlled by standard inhalers. About 135 participants will receive either one of two doses of linvemastat or a placebo, while continuing their usual medications. Over 16 weeks,…

This study tests whether a device that stimulates the spinal cord — called pulmonary neuromodulation — can improve asthma control in adults with moderate to severe asthma that remains uncontrolled despite high-dose inhalers or biologic medications. Participants receive the implan…

This study tests whether taking chromium picolinate daily for 12 weeks improves asthma control in obese adults. Researchers believe that chromium may help by addressing metabolic issues like insulin resistance that can worsen asthma. Sixty participants will receive either the sup…

This study tracks people with severe eosinophilic asthma who already take Fasenra (benralizumab) every 8 weeks. Participants use electronic monitors on their regular inhalers and a study-provided rescue inhaler (AirSupra) to see if asthma control stays steady throughout the dosin…

This study tests a new injectable drug called depemokimab in 30 children aged 6 to 11 with asthma that involves a specific type of inflammation. The drug is given alongside their usual asthma medicines to see how the body processes it, how well it works, and if it is safe. The go…

This study observes 210 patients in South Korea who are prescribed Tezepelumab for severe asthma or chronic sinusitis with nasal polyps. Researchers will track side effects and how well the drug controls symptoms in everyday use. The goal is to confirm the drug's safety and effec…

This study tests whether text-message reminders and coaching can help 389 teens (ages 12-18) with moderate to severe asthma take their daily inhaled steroids as prescribed. Participants will be split into three groups: one gets a basic asthma app, another adds personalized text r…

This study tests two ways to use asthma inhalers to prevent serious attacks. One strategy (MART) uses a combination inhaler for daily control and quick relief. The other (PARTICS) adds a separate steroid inhaler whenever a rescue inhaler is used. About 4,100 adults with moderate-…

This Phase 2 trial tests an injectable drug called RC1416 in 195 adults with moderate to severe asthma that is not well controlled. Participants will receive either the drug or a placebo by injection. The study will measure changes in lung function and track asthma attacks over t…

This Phase 3 trial tests a new inhaler called N0783 against a standard asthma inhaler (Alenia) in 174 adults with moderate asthma. The goal is to see if the new drug works just as well at improving lung function and controlling symptoms. Participants will be randomly assigned to …

This study tests whether adding black seed oil (Nigella sativa) to standard asthma medication can improve asthma control and lung function in children aged 6–18 with moderate persistent asthma. Ninety children will receive either a low or high dose of black seed oil capsules or a…

This study tests whether a new drug called QL2302 works as well as the approved drug Tezspire for people with severe asthma that is not controlled by current treatments. About 636 adults aged 18-80 will receive injections every 4 weeks for 48 weeks, then be monitored for another …

This Phase 2 trial tests AD17002, a nasal spray that aims to calm the immune system in people with moderate to severe eosinophilic asthma that is not well controlled by current treatments. About 126 adults will receive either the spray or a placebo for 3 months. Researchers will …

This pilot study tests whether anakinra, a drug that reduces inflammation, can help people with moderate asthma attacks. 60 adults at high risk for asthma attacks will either receive anakinra or a placebo at home when they feel an attack starting. The study will check if this app…

This study tests whether acupuncture can help people with mild-to-moderate chronic asthma breathe better and feel less anxious or depressed. 180 adults will be randomly assigned to real acupuncture, fake acupuncture, or usual care. The main goal is to see if real acupuncture impr…

This study looks at whether biologic therapy can reverse long-term lung damage in adults with severe asthma. Researchers will follow 150 patients and 50 healthy volunteers for two years, using advanced imaging and lung function tests. The goal is to see if treatment leads to 'cli…

This study tests whether a prefilled autoinjector delivers the drug SHR-1703 as effectively as a standard prefilled syringe in healthy adults. The goal is to see if the autoinjector provides a similar level of drug in the blood, which could make future injections easier for peopl…

This study uses a quick, non-invasive breath test (FeNO) to measure airway inflammation in adults with asthma who are treated in primary care or community specialty clinics. The goal is to see how many patients have type 2 inflammation, which often goes undetected. Researchers ho…