Carotid artery disorder

This study follows 1,200 people who received special fabric tubes (grafts) to repair or replace damaged arteries in the neck, belly, or legs. Researchers want to see how well the grafts work over time and how often problems like blockages or infections happen. It is an observatio…

This trial tests whether placing a stent in a narrowed or blocked neck artery during emergency stroke treatment helps people recover better than just removing the clot in the brain. About 15-20% of severe strokes involve both a brain clot and a neck artery blockage. The study wil…

This study tests a new device that uses sound waves (lithotripsy) to break up hard calcium deposits in the carotid arteries of the neck before placing a stent. About 185 people with heavily calcified carotid arteries will be enrolled. The main goal is to see if the procedure is s…

This study looks at how long people at high risk of bleeding should take two blood thinners after having a carotid artery stent placed. About 1,556 participants will first take both aspirin and clopidogrel for 30 days, then be split into two groups: one continues both drugs for 1…

This study tests whether breathing in a safe, inexpensive gas called argon during carotid artery surgery can prevent brain damage and confusion after the operation. About 100 adults having elective carotid surgery will be randomly assigned to receive either argon gas or a placebo…

This study tests a new decision-making tool called IMPROVE that uses MRI scans to detect unstable plaques in the carotid artery. The goal is to see if this method is at least as good as the current standard (which mainly looks at how narrow the artery is) for selecting which pati…

This study compares a stent (CARESTO® heal) plus standard medication against medication alone in 536 people who recently had a stroke or retinal artery blockage due to a specific type of carotid artery disease that is not severely narrowed. The goal is to see if the stent can low…

This registry will follow 8,000 people with severe carotid artery disease who receive a stent to open the blocked artery. The main goal is to track how many have a stroke or die within 30 days of the procedure. The results will help select skilled doctors for a larger randomized …

This study tests whether a team of healthcare professionals using a special algorithm can lower 'bad' cholesterol (LDL-C) more effectively than standard care in people with heart or blood vessel disease. About 100 adults with high cholesterol and known vascular disease will be ra…

This study tests whether treating severe gum disease can reduce inflammation in the arteries of people who have recently had a heart attack. 210 participants will be randomly assigned to receive either intensive periodontal treatment or standard dental care. The main goal is to s…

This study compares two types of CT scans for imaging the buildup of plaque in the carotid arteries, which supply blood to the brain. The newer photon-counting detector CT (PCD-CTA) will be compared with the standard energy-integrating detector CT (EID-CTA) in 100 people with car…

This study tests a new 3D ultrasound probe to see tiny blood vessels inside fatty plaques in the neck arteries. These vessels can make plaques more likely to rupture and cause a stroke. Ten people who already had a standard ultrasound will get this new 3D scan with a contrast dye…

This study tests whether using a carotid ultrasound (a neck scan) to find hidden plaque in arteries can help prevent heart attacks and strokes in people with inflammatory rheumatic diseases like rheumatoid arthritis or lupus. About 1,944 participants aged 50 and older will be spl…

This study is looking at how a protein called SNRK might be linked to aging of blood vessels. Researchers will take blood samples and use ultrasound to check artery stiffness in 180 adults aged 18 to 80. The goal is to find new ways to understand and possibly treat vascular aging…

This study looks at whether menopause and HIV together increase heart disease risk in women. Researchers will examine inflammation and body fat using MRI scans and blood tests in 90 women with HIV. The goal is to understand why heart risks may worsen after menopause in this group…

This study looks at whether bacteria in your mouth can influence the buildup of fatty plaques in the neck arteries that supply blood to the brain. Researchers will collect samples from 200 adults having surgery to remove these plaques and compare the bacteria found in the mouth, …

This study is testing whether a new type of PET-MR scan can help predict stroke risk in people with significant narrowing of the carotid artery (the main artery in the neck) who have not yet had symptoms. Researchers will give participants an injection of a radioactive tracer and…

This study is testing whether a deep learning model can predict cerebral hyperperfusion syndrome (CHS), a rare but serious brain complication that can occur after carotid artery surgery. Researchers will enroll 500 adults aged 30-80 who are having carotid revascularization. The g…