Blood coagulation disease
MONDO:0001531A condition in which there is a deviation from or interruption of the normal coagulation properties of the blood.
Also known as: blood coagulation disorder, coagulation defect, coagulation disorder, coagulation disorder, blood, coagulation disorders, blood, coagulopathy, disorder, blood coagulation, disorders, blood coagulation
541 clinical trials for this condition and its sub-types, 54 tagged with Blood coagulation disease itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Part of
Sub-types of Blood coagulation disease
-
Inherited blood coagulation disorder 8 trials · 323 incl. sub-types
39 sub-types
- Hemophilia A 180 trials Sub-types →
- Hemophilia B 84 trials · 91 incl. sub-types Sub-types →
- Hereditary von Willebrand disease 18 trials · 29 incl. sub-types Sub-types →
- Inherited thrombophilia 0 trials · 28 incl. sub-types Sub-types →
- Hereditary hemolytic uremic syndrome 0 trials · 19 incl. sub-types Sub-types →
- Wiskott-Aldrich syndrome 10 trials
- Glanzmann thrombasthenia 8 trials Sub-types →
- Platelet-type bleeding disorder 10 8 trials
- Congenital thrombotic thrombocytopenic purpura 5 trials
- Hereditary thrombocytopenia and hematologic cancer predisposition syndrome 1 trial · 5 incl. sub-types Sub-types →
- Hermansky-Pudlak syndrome 4 trials Sub-types →
- Congenital vitamin K-dependent coagulation factors deficiency 0 trials · 4 incl. sub-types Sub-types →
- Congenital factor XII deficiency 1 trial
- Congenital plasminogen activator inhibitor type 1 deficiency 1 trial
- Hypoplasminogenemia 1 trial
- Ehlers-Danlos syndrome, fibronectinemic type 0 trials
- Scott syndrome 0 trials
- Tatsumi factor deficiency 0 trials
- Alpha-2-plasmin inhibitor deficiency 0 trials
- Congenital factor V deficiency 0 trials
- Congenital factor XI deficiency 0 trials
- Congenital high-molecular-weight kininogen deficiency 0 trials
- Cytosolic phospholipase-A2 alpha deficiency associated bleeding disorder 0 trials
- Dysplasminogenemia 0 trials
- Factor 5 and Factor VIII, combined deficiency of, 2 0 trials
- Factor V and factor VIII, combined deficiency of, type 1 0 trials
- Factor VII and Factor VIII, combined deficiency of 0 trials
- Factor XIII, A subunit, deficiency of 0 trials
- Factor XIII, b subunit, deficiency of 0 trials
- Familial thrombomodulin anomalies 0 trials
- Hereditary thrombocytosis with transverse limb defect 0 trials
- Hypercoagulability syndrome due to glycosylphosphatidylinositol deficiency 0 trials
- Inherited prekallikrein deficiency 0 trials
- Plasminogen deficiency, type II 0 trials
- Platelet-type bleeding disorder 12 0 trials
- Platelet-type bleeding disorder 14 0 trials
- Platelet-type bleeding disorder 16 0 trials
- Platelet-type bleeding disorder 18 0 trials
- Platelet-type bleeding disorder 8 0 trials
-
Coagulation protein disease 13 trials · 274 incl. sub-types
28 sub-types
- Hemophilia 55 trials · 216 incl. sub-types Sub-types →
- Von Willebrand disease (hereditary or acquired) 39 trials · 46 incl. sub-types Sub-types →
- Acquired coagulation factor deficiency 4 trials · 16 incl. sub-types Sub-types →
- Congenital fibrinogen deficiency 2 trials · 6 incl. sub-types Sub-types →
- Factor VII deficiency 6 trials Sub-types →
- Thrombophilia due to activated protein C resistance 5 trials
- Congenital vitamin K-dependent coagulation factors deficiency 0 trials · 4 incl. sub-types Sub-types →
- Factor X deficiency 2 trials Sub-types →
- Congenital factor XII deficiency 1 trial
- Congenital plasminogen activator inhibitor type 1 deficiency 1 trial
- Hypoplasminogenemia 1 trial
- East Texas bleeding disorder 0 trials
- Tatsumi factor deficiency 0 trials
- Alpha-2-plasmin inhibitor deficiency 0 trials
- Combined deficiency of factor V and factor VIII 0 trials Sub-types →
- Combined deficiency of factor VII and factor X 0 trials
- Congenital high-molecular-weight kininogen deficiency 0 trials
- Dysplasminogenemia 0 trials
- Factor V amsterdam bleeding disorder 0 trials
- Factor V atlanta bleeding disorder 0 trials
- Factor V deficiency 0 trials Sub-types →
- Factor V short isoforms-related bleeding disorder 0 trials
- Factor XIII deficiency 0 trials Sub-types →
- Hemorrhagic disease due to alpha-1-antitrypsin Pittsburgh mutation 0 trials
- Inherited prekallikrein deficiency 0 trials
- Multiple sclerosis-ichthyosis-factor VIII deficiency syndrome 0 trials
- Plasminogen deficiency, type II 0 trials
- Thrombomodulin-related bleeding disorder 0 trials
-
Thrombotic microangiopathy 26 trials · 151 incl. sub-types
2 sub-types
- Thrombocytopenic purpura 8 trials · 116 incl. sub-types Sub-types →
- Atypical hemolytic-uremic syndrome 19 trials Sub-types →
-
Thrombophilia 12 trials · 75 incl. sub-types
4 sub-types
- Inherited thrombophilia 0 trials · 28 incl. sub-types Sub-types →
- Thrombotic thrombocytopenic purpura 15 trials · 20 incl. sub-types Sub-types →
- Disseminated intravascular coagulation 15 trials Sub-types →
- Protein S deficiency 3 trials Sub-types →
-
Hemolytic-uremic syndrome 7 trials · 24 incl. sub-types
2 sub-types
- Hereditary hemolytic uremic syndrome 0 trials · 19 incl. sub-types Sub-types →
- Infection-related hemolytic uremic syndrome 0 trials · 2 incl. sub-types Sub-types →
-
Hemorrhagic disease of newborn 1 trial
-
Marantic endocarditis 0 trials
-
Prekallikrein deficiency 0 trials
1 sub-type
- Inherited prekallikrein deficiency 0 trials
Most studied deeper sub-types
-
Quick-Clot powder could save lives in severe trauma bleeding
Disease control CompletedThis study compares two treatments to help blood clot in severely injured trauma patients who are bleeding heavily. One is a standard frozen blood product (cryoprecipitate) that takes time to thaw, and the other is a dry powder (fibrinogen concentrate) that can be given at the be…
Phase 3 • Sponsor: Australian and New Zealand Intensive Care Research Centre • Aim: Disease control
Last updated Sep 11, 2026 00:00 UTC
-
One-shot gene therapy aims to free hemophilia patients from constant infusions
Disease control CompletedThis trial tests a gene therapy called valoctocogene roxaparvovec for people with severe hemophilia A who have developed inhibitors (antibodies that block standard treatment). The therapy uses a harmless virus to deliver a working copy of the gene for clotting factor VIII, so the…
Phase 1/2 • Sponsor: BioMarin Pharmaceutical • Aim: Disease control
Last updated Jul 12, 2026 00:00 UTC
-
Weekly shot aims to get severe hemophilia patients moving more
Disease control CompletedThis study is testing a new medicine called efanesoctocog alfa in about 90 people aged 12 and older with severe hemophilia A. Participants receive a weekly injection for 24 months to see if it helps them be more physically active and improves joint health. The study uses activity…
Phase 3 • Sponsor: Swedish Orphan Biovitrum • Aim: Disease control
Last updated Jul 04, 2026 00:00 UTC
-
Battlefield plasma goes civil: can a powder save trauma victims?
Disease control CompletedThis study tested a freeze-dried plasma product that can be mixed with water in 6 minutes, avoiding the long thaw time of standard plasma. It included 42 trauma patients with severe bleeding who needed blood transfusions. The goal was to see if faster plasma delivery could improv…
Phase 3 • Sponsor: University Hospital, Lille • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
-
Can donor plasma fix clotting issues in sepsis? new study investigates
Disease control CompletedThis study tests whether a special donor plasma product called OctaplasLG can help people with septic shock who develop blood clotting problems. Sixty participants will receive either OctaplasLG or a placebo (salt water) to see if the treatment improves clotting and outcomes. The…
Sponsor: University Hospital, Strasbourg, France • Aim: Disease control
Last updated Jun 27, 2026 11:02 UTC
-
Whole blood may be just as good as standard transfusions for trauma bleeding
Disease control CompletedThis study looked at whether giving whole blood (all blood parts together) works as well as giving separate blood parts (red cells, plasma, platelets) to people with severe bleeding from trauma. About 200 patients who needed a massive transfusion were included. The goal was to se…
Phase 3 • Sponsor: Direction Centrale du Service de Santé des Armées • Aim: Disease control
Last updated Jun 27, 2026 08:14 UTC
-
One-Time gene therapy shows promise for hemophilia a
Disease control CompletedThis study tested a one-time gene therapy (valoctocogene roxaparvovec) in 22 adults with severe hemophilia A. The treatment aims to help the body produce its own clotting factor VIII, reducing the need for regular infusions. Participants also received steroids to manage immune re…
Phase 3 • Sponsor: BioMarin Pharmaceutical • Aim: Disease control
Last updated Jun 27, 2026 07:53 UTC
-
Real-World study tracks Alprolix's bleeding control in hemophilia b
Disease control CompletedThis study followed 151 people with hemophilia B who were already using or starting Alprolix, a long-lasting clotting factor. Over 24 months, researchers tracked how often bleeding occurred, how often the drug was injected, and how much was used. The goal was to see how well Alpr…
Sponsor: Swedish Orphan Biovitrum • Aim: Disease control
Last updated Jun 27, 2026 07:52 UTC
-
New powdered plasma shows promise in early safety trial
Disease control CompletedThis early study tested the safety of a new spray-dried plasma product called FrontlineODP in 24 healthy volunteers. Participants received increasing doses (1 to 4 units) to see if it causes side effects. The goal is to develop a shelf-stable plasma that can be stored at room tem…
Phase 1 • Sponsor: Velico Medical • Aim: Disease control
Last updated Jun 26, 2026 17:56 UTC
-
Can a Lab-Made clotting factor outsmart blood thinners?
Prevention CompletedResearchers are testing a new drug called VMX-C001 to see if it can help blood clot normally in people who take common blood thinners. The trial gives single doses of VMX-C001 or a placebo to healthy volunteers, and also to healthy older adults who take one of three blood thinner…
Phase 1 • Sponsor: VarmX B.V. • Aim: Prevention
Last updated Sep 11, 2026 00:00 UTC
-
New study aims to uncover why catheters cause blood clots
Knowledge-focused CompletedThis study looks at how four types of central venous catheters (thin tubes placed in large veins) affect the body's clotting system. Researchers will take blood samples from 88 adults right after catheter insertion and again after flushing, to measure clotting changes. The goal i…
Sponsor: Thomas Kander • Aim: Knowledge-focused
Last updated Sep 18, 2026 00:00 UTC
-
New hemophilia drug may last longer, reducing need for frequent shots
Knowledge-focused CompletedThis study tested a new drug called efanesoctocog alfa in 24 adults with severe hemophilia A. Researchers compared how long it stays in the body versus two existing drugs. Participants received one dose of their usual drug, then later one dose of the new drug, with blood samples …
Phase 1 • Sponsor: Swedish Orphan Biovitrum • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:03 UTC
-
C-Section pain relief: does ketorolac raise bleeding risk?
Knowledge-focused CompletedThis study looked at how ketorolac, a non-steroidal anti-inflammatory drug (NSAID) used for pain after cesarean delivery, affects platelet function and blood clotting. Researchers measured clotting in 40 women undergoing scheduled C-sections using special blood tests. The goal wa…
Phase 4 • Sponsor: Beth Israel Deaconess Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:00 UTC
-
Experimental clotting agent VMX-C001 tested with common blood thinners
Knowledge-focused CompletedThis early study tested an experimental drug called VMX-C001 in 16 healthy adults to see how it affects blood clotting when taken with common blood thinners like rivaroxaban and enoxaparin. The goal was to measure changes in various clotting tests, not to treat any disease. Becau…
Phase 1 • Sponsor: VarmX B.V. • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:32 UTC
-
Magnesium levels linked to clotting risk in sepsis
Knowledge-focused CompletedThis study looked at 150 adults with sepsis in the ICU to see if low magnesium levels are connected to blood clotting problems. Researchers measured magnesium and clotting markers at admission and tracked outcomes like DIC and survival. The goal was to understand if magnesium cou…
Sponsor: Ain Shams University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:30 UTC
-
Can a computer program help doctors decode clotting tests?
Knowledge-focused CompletedThis study tested whether a new software program helps doctors more accurately interpret ROTEM blood clotting tests. Twenty-six doctors and residents from the University of Utah took part. Researchers compared their answers before and after using the software to see if it improve…
Sponsor: University of Utah • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:24 UTC
-
New test and tiny particles could help manage bleeding in liver disease
Knowledge-focused CompletedThis study looked at how blood clots in people with liver cirrhosis, a condition that can cause bleeding problems. Researchers used a special machine called T-TAS to measure clotting in blood samples from 60 patients. They also tested whether tiny particles that act like platelet…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
-
IV nutrition may change blood clotting, large study finds
Knowledge-focused CompletedThis completed observational study looked at how intravenous lipid emulsions (fat-containing nutrition given through a vein) affect blood clotting in 6,259 hospitalized patients. Researchers compared clotting tests before and after patients received these emulsions as part of rou…
Sponsor: Mimi Tang, PhD • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:01 UTC
-
Scientists watch sepsis damage tiny vessels in real time
Knowledge-focused CompletedThis completed study looked at 30 adults with sepsis to understand how changes in tiny blood vessels (microcirculation) relate to blood clotting problems. Researchers used a special microscope to view blood vessels under the tongue and measured clotting factors. The goal was to s…
Sponsor: Università Politecnica delle Marche • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:04 UTC
-
COVID-19 blood clot mystery: new study aims to unravel why some patients develop dangerous clots
Knowledge-focused CompletedThis completed study looked at blood clotting in 175 hospitalized COVID-19 patients. Researchers used a special test to measure how quickly and strongly blood clots form, and whether a protein called thrombomodulin can slow this process. The goal was to understand why some COVID-…
Sponsor: Centre Hospitalier Universitaire de Nīmes • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:01 UTC
-
Cancer patients face higher clot risk – new study aims to understand why
Knowledge-focused CompletedThis study looked at 700 cancer patients to understand how often dangerous blood clots occur and how blood-thinning medications affect them. Researchers tracked patients over two years, analyzing blood samples and clotting events. The goal is to improve prevention and treatment o…
Sponsor: Centre Antoine Lacassagne • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:53 UTC