Astrocytoma (excluding glioblastoma)

This study tested a combination of two chemotherapy drugs (BCNU and TMZ) given before radiation therapy in 53 people newly diagnosed with a rare type of brain cancer called anaplastic oligodendroglioma. The goal was to see how well the drugs shrank tumors and to learn more about …

This study tested a drug called AB-218 (safusidenib) in 14 adults with a specific type of slow-growing brain tumor (IDH1 mutated low grade glioma) who were already scheduled for surgery. The goal was to see if it's possible to measure how much drug gets into the tumor and to chec…

This early-phase trial tested a new treatment for aggressive brain tumors called high-grade glioma. Sixteen patients received a drug (5-ALA) plus focused ultrasound to activate the drug inside the tumor, a few days before standard surgery and chemo-radiation. The main goal was to…

This study tested a wearable device called NOVOTTF-200A in people with recurrent Grade III astrocytoma, a type of brain cancer. The device delivers low-intensity electric fields to the brain to slow tumor growth. Only 1 participant was enrolled, and the main goal was to see if th…

This early-phase study tested an experimental drug called INCB7839 in 13 children whose high-grade gliomas (aggressive brain tumors) had come back or worsened after standard treatment. The main goals were to find a safe dose and check for side effects. The drug works by blocking …

This study tested giving a second round of radiation to people whose glioblastoma (a fast-growing brain tumor) came back after standard treatment. Seventeen adults aged 18 to 50 received daily radiation for 2-3 weeks. The goal was to find the safest highest dose and see how it af…

This early-phase study tested a new drug called TG02 in 71 patients with aggressive brain cancers (anaplastic astrocytoma or glioblastoma). The goal was to find the safest dose when combined with either radiation or chemotherapy. The study included newly diagnosed elderly patient…

This study tests whether a fluorescent dye called tozuleristide, given before surgery, can make brain tumor tissue glow under a special imaging system. Surgeons can then see and remove more of the tumor while sparing healthy brain. The trial enrolls adults with certain types of b…

This study tests whether an artificial intelligence system called GliomaAI-Astro23 can identify a specific type of brain tumor (IDH mutant astrocytoma) from routine MRI scans. Researchers are using existing MRI data from 1,372 patients to train and evaluate the AI. If accurate, t…

This study tests whether an artificial intelligence system called GliomaAI-Astro4 can accurately detect a specific type of brain tumor (IDH mutant astrocytoma grade 4) using routine MRI scans. Researchers will analyze previously collected, anonymized MRI data from 1,372 patients …

This study tests whether an artificial intelligence system called GliomaAI-Oligo can detect a specific type of brain tumor (oligodendroglioma) from routine MRI scans. Researchers will use over 1,300 existing, anonymized scans from multiple hospitals to train and evaluate the AI. …

This study looked at whether video doctor visits (telehealth) work as well as in-person visits for people with brain tumors (gliomas) who are taking oral chemotherapy. 30 patients took part, alternating between telehealth and in-person checkups. The goal was to see which type of …

This pilot study tested a new way to deliver radiation therapy to people with recurrent IDH-mutant gliomas who had already received radiation to the brain. Instead of giving one large dose, the radiation was given in many small, timed pulses to reduce side effects. The study incl…

This study tested a type of talk therapy called Cognitive Behavioral Therapy for Insomnia (CBT-I) in 70 people with brain tumors who also had trouble sleeping. The therapy involved six weekly group sessions delivered online. The main goal was to see if the approach was practical …

This completed study enrolled over 1,200 people with brain or spinal cord tumors to collect medical information, blood samples, and tumor tissue. The goal was to better understand these cancers and identify promising areas for future research. Participants also received guidance …

This pilot trial explores whether using a tumor's molecular profile—its gene expression and DNA sequencing—can help doctors choose a personalized treatment plan for children and young adults with high-grade glioma (a type of brain cancer). Participants receive a recommendation fr…

This completed study surveyed 100 adults with brain tumors (gliomas) to understand how social factors like income, education, housing, and community support affect their health. Participants answered questionnaires about their neighborhoods, access to food and transportation, and…

This study reviewed medical records of 37 children under 18 diagnosed with rare brain tumors called DIA or DIG between 1996 and 2015 in French cancer centers. Researchers wanted to find out why some of these usually benign tumors become malignant. By analyzing clinical, genetic, …

This pilot study tested whether a special PET scan using 18F-FDOPA can help doctors better plan surgery and radiation for people with newly diagnosed brain tumors (gliomas). Twenty-four adults took part at Mayo Clinic. The goal was to see if the scan provides useful information b…