Anosmia

This trial tests whether a 12-week smell training program can help people who lost their sense of smell after COVID-19. Participants will sniff four different scents twice daily, with one group using rose, orange, clove, and eucalyptus, and another using cheese, coffee, strawberr…

This study tests whether combining a mild electrical nerve stimulation on the forehead with standard smell training can improve smell function in adults with smell loss. Participants use a small device at home for 8 weeks while smelling four different odors. Researchers measure c…

This study tests whether a device called ScentCare, used with a companion app, can improve smell and well-being in adults aged 60 and older who have lost their sense of smell. Participants will use the device or solve Sudoku puzzles twice daily for three months. Researchers will …

This study tests two at-home treatments—smell training and a gentle nerve stimulation device—for people with long COVID who have lost or distorted their sense of smell. About 145 adults will do daily sessions at home and attend three clinic visits over 12 weeks. The goal is to se…

This study follows 30 people with chronic sinusitis and nasal polyps who are starting dupilumab, a medication that can help restore smell. Researchers want to see if the degree of nasal blockage or specific electrical signals from the brain can predict who will regain their sense…

This study looks at people with smell loss caused by chronic rhinosinusitis. Participants will undergo a 3-month smell training program. Researchers will measure changes in smell function, mental health, and immune markers in blood and tissue samples. The goal is to understand th…

This 18-month study tests whether a smartphone app with game-like features can help adults aged 40+ with a reduced sense of smell become more active. 110 participants will be randomly assigned to either a full-dose programme aiming to double their daily steps or a low-dose contro…

This study collects a small sample of tissue from inside the nose to learn how the sense of smell changes in people with Alzheimer's. Researchers will compare samples from healthy volunteers and those with early or mild Alzheimer's. The goal is to understand the biology behind sm…

About 30 million US adults suffer from nasal sinus disease, often causing nasal obstruction and loss of smell. This study from Ohio State University will test a nasal plug (similar to a swimmer's nose clip) as a tool to better evaluate these symptoms. Researchers hope to develop …

This study follows 80 children aged 2-8 with cystic fibrosis to see how highly effective CF drugs (Kalydeco or Trikafta) impact sinus disease and sense of smell. Researchers will use MRI scans, smell tests, and quality-of-life surveys over two years. The goal is to understand whe…

This study is a registry that follows 500 people with smell or taste disorders to learn more about how these conditions progress and affect quality of life. Participants complete standard tests and questionnaires during their clinic visits. The goal is to better understand these …