Anosmia
MONDO:0010528Loss of or impaired ability to smell. This may be caused by olfactory nerve diseases; paranasal sinus diseases; viral respiratory tract infections; craniocerebral trauma; smoking; and other conditions.
Also known as: anosmia, anosmia (disease)
32 clinical trials for this condition and its sub-types.
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Broader categories
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Asthma drug shows promise for lost smell after head trauma
Disease control CompletedThis study tested whether theophylline, an asthma drug, could help people who lost their sense of smell after a head injury. 158 patients who had not improved with standard treatments took theophylline or a placebo, plus did smell training for 6 months. The goal was to see if the…
Phase: PHASE4 • Sponsor: Taichung Veterans General Hospital • Aim: Disease control
Last updated Jun 26, 2026 16:45 UTC
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Autism smell and taste study tests natural supplement
Symptom relief CompletedThis study tested whether a natural supplement called ultramicronized palmitoylethanolamide (umPEA) can improve smell, taste, and other sensory issues in children with autism. Eighty children took either umPEA or a standard treatment (probiotics plus omega-3) for six months. Rese…
Phase: NA • Sponsor: University of Campania Luigi Vanvitelli • Aim: Symptom relief
Last updated Jun 27, 2026 13:04 UTC
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Chewing gum may be the surprising new tool to recover smell and taste
Symptom relief CompletedThis pilot study tested whether chewing flavored gum twice a day for 12 weeks could help people recover their sense of smell and taste. Thirty adults with smell or taste loss were split into three groups: one chewed flavored gum, one smelled liquid flavors, and one waited. The st…
Phase: NA • Sponsor: University of Nottingham • Aim: Symptom relief
Last updated Jun 27, 2026 12:01 UTC
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Sniffing scents may speed smell recovery after brain surgery
Symptom relief CompletedThis study looked at whether smell training with scented oils can help people regain their sense of smell after endoscopic skull base surgery. 41 adults with benign skull base tumors participated. Half used scented sticks and half used unscented sticks for training. Researchers m…
Phase: NA • Sponsor: Johns Hopkins University • Aim: Symptom relief
Last updated Jun 27, 2026 09:06 UTC
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New drug aims to restore lost smell in clinical trial
Symptom relief CompletedThis study tested a new drug called CYR-064 in 151 adults aged 18-70 who have a reduced sense of smell (hyposmia). The goal was to see if the drug is safe and if it can improve smell and taste over 24 weeks compared to a placebo. Participants had no other nasal issues like polyps…
Phase: PHASE2 • Sponsor: Cyrano Therapeutics, Inc. • Aim: Symptom relief
Last updated Jun 27, 2026 09:06 UTC
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Neck injection may restore smell in long COVID patients
Symptom relief CompletedThis pilot study tested whether a stellate ganglion block—a numbing injection near a nerve cluster in the neck—can help people who lost their sense of smell after COVID-19. Twenty adults with smell problems lasting at least a year received the injection. Researchers measured chan…
Phase: PHASE1, PHASE2 • Sponsor: Washington University School of Medicine • Aim: Symptom relief
Last updated Jun 27, 2026 09:04 UTC
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Smell lost to COVID? nasal steroid rinse shows promise in trial
Symptom relief CompletedThis study tested whether a budesonide nasal rinse (a steroid) could improve smell loss in 120 adults who still had trouble smelling 30 days after a mild COVID-19 infection. Participants used the rinse twice daily for 30 days, along with smell training. The goal was to see if mor…
Phase: PHASE3 • Sponsor: Fondation Ophtalmologique Adolphe de Rothschild • Aim: Symptom relief
Last updated Jun 27, 2026 08:09 UTC
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Nerve block may fix COVID smell problems, study says
Symptom relief CompletedThis study tested whether a stellate ganglion block (an injection near nerves in the neck) can improve distorted sense of smell (parosmia) caused by COVID-19. 48 adults with long-term smell issues after COVID took part. Half received the nerve block, half got a placebo (saline). …
Phase: PHASE2 • Sponsor: Washington University School of Medicine • Aim: Symptom relief
Last updated Jun 27, 2026 07:56 UTC
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Could scented nose plugs be the key to restoring lost smell?
Symptom relief CompletedThis study tested whether scented nose plugs could make smell training more effective for people who lost their sense of smell after a virus like COVID-19. 120 adults with reduced smell were split into two groups: one did regular smell training at home, and the other used scented…
Phase: NA • Sponsor: Karolinska Institutet • Aim: Symptom relief
Last updated Jun 26, 2026 12:46 UTC
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Lost your smell after COVID? simple training may help
Knowledge-focused CompletedThis study looked at 176 people who had COVID-19 and were having problems with smell, taste, or saliva. Researchers tested their senses and tried smell training as a way to help. The goal was to better understand these long-lasting symptoms and how to manage them.
Phase: NA • Sponsor: University of Oslo • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:29 UTC
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Could your nose warn of a rare heart disease?
Knowledge-focused CompletedThis study checked how common smell and taste problems are in 51 people with cardiac amyloidosis, a rare disease where abnormal proteins build up in the heart. Researchers used a simple smell test called Sniffin' Sticks to measure these senses. The goal was to see if these issues…
Phase: NA • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:05 UTC
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After gastric bypass, do your senses sabotage your diet?
Knowledge-focused CompletedThis study looked at 101 adults who had weight-loss surgery at least three months earlier. Researchers asked about changes in taste and smell, and how those changes relate to hunger and diet quality. The goal is to understand whether sensory shifts make it harder to eat well afte…
Sponsor: Hanife Köksal • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:04 UTC