Acute transplant rejection
MONDO:1010187A transplant rejection that is caused by an immune response directed against the graft and occurs between 1 week and several months after transplantation. Acute rejection is diagnosed on histological analysis of a graft biopsy. Acute rejection is thought to result from two immunological mechanisms that may act alone or in combination: (1) a T-cell-dependent process that corresponds to acute cellular rejection, and (2) a B-cell-dependent process that generates the acute humoral rejection.
39 clinical trials for this condition and its sub-types.
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New hope for kidney transplant patients facing rejection
Disease control OngoingThis study tests a new drug called ALXN2030 in 45 adults who have had a kidney transplant and are experiencing antibody-mediated rejection (AMR). The goal is to see if the drug can help resolve signs of rejection seen on a kidney biopsy after one year of treatment. Participants w…
Phase: PHASE2 • Sponsor: Alexion Pharmaceuticals, Inc. • Aim: Disease control
Last updated Aug 13, 2026 00:00 UTC
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Can a new drug combo save failing kidney transplants?
Disease control OngoingThis phase 3 trial is testing whether adding tocilizumab to standard care can slow the decline in kidney function for people who have chronic antibody-mediated rejection after a kidney transplant. Half of the 50 participants will receive tocilizumab plus standard care, while the …
Phase: PHASE3 • Sponsor: Vastra Gotaland Region • Aim: Disease control
Last updated Aug 12, 2026 00:00 UTC
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New hope for kidney transplant patients: extended drug trial targets rejection
Disease control ENROLLING_BY_INVITATIONThis study offers kidney transplant patients with antibody-mediated rejection (AMR) the chance to receive felzartamab for up to 4 more years. AMR occurs when the immune system attacks the new kidney. The main goal is to check long-term safety and monitor kidney health through bio…
Phase: PHASE3 • Sponsor: Biogen • Aim: Disease control
Last updated Aug 08, 2026 00:03 UTC
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New shot could help kidney transplant patients fight rejection
Disease control OngoingThis study tests a drug called efgartigimod, given as a shot under the skin, for people who have antibody-mediated rejection after a kidney transplant. The trial includes 30 adults who received a kidney at least 6 months ago and have signs of rejection. Participants will receive …
Phase: PHASE2 • Sponsor: argenx • Aim: Disease control
Last updated Jul 04, 2026 00:00 UTC
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New drug could save transplanted kidneys from rejection
Disease control OngoingThis study tests a drug called felzartamab in people who received a kidney transplant and later developed antibody-mediated rejection (AMR), where the immune system attacks the new kidney. The drug targets immune cells that make harmful antibodies, aiming to reduce kidney damage …
Phase: PHASE3 • Sponsor: Biogen • Aim: Disease control
Last updated Jun 27, 2026 13:03 UTC
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AI may spot hidden kidney transplant rejection
Knowledge-focused OngoingThis study is developing an artificial intelligence (AI) system to analyze kidney biopsy images from transplant patients. The goal is to see if AI can accurately tell apart different types of rejection, measure how much damage the kidney has, and predict if rejection might come b…
Sponsor: Chen Dajin • Aim: Knowledge-focused
Last updated Aug 05, 2026 00:00 UTC
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Gene clues may explain why light therapy helps some transplant patients
Knowledge-focused OngoingThis study looks at gene activity in blood cells from 30 kidney or lung transplant patients who have chronic rejection. Researchers want to find out why some patients improve with a treatment called extracorporeal photoapheresis (ECP) while others do not. The goal is to better un…
Sponsor: Fondazione IRCCS Policlinico San Matteo di Pavia • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:09 UTC
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Blood test may replace needles for kids with kidney rejection
Knowledge-focused OngoingThis study looks at whether a blood test can help doctors know if treatment for kidney rejection is working in children who have had a kidney transplant. About 27 kids will give blood samples to check for special markers. The goal is to see if the blood test can predict and monit…
Sponsor: University of Minnesota • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:04 UTC
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AI aims to replace needle biopsies for kidney transplant patients
Knowledge-focused TerminatedThis study planned to create artificial intelligence tools that could diagnose kidney transplant rejection using urine tests instead of invasive biopsies. Researchers wanted to combine urine markers with standard medical data to make diagnosis safer and easier. However, the study…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:51 UTC