Acute transplant rejection
MONDO:1010187A transplant rejection that is caused by an immune response directed against the graft and occurs between 1 week and several months after transplantation. Acute rejection is diagnosed on histological analysis of a graft biopsy. Acute rejection is thought to result from two immunological mechanisms that may act alone or in combination: (1) a T-cell-dependent process that corresponds to acute cellular rejection, and (2) a B-cell-dependent process that generates the acute humoral rejection.
39 clinical trials for this condition and its sub-types.
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Can a new infusion stop the Body's attack on a transplanted kidney?
Disease control Not yet recruitingThis trial tests an experimental drug called SG301 in people who have antibody-mediated rejection after a kidney transplant. The goal is to see if the drug is safe and may help control the immune system's attack on the new kidney. Participants receive the drug by infusion weekly …
Phase: PHASE2 • Sponsor: Hangzhou Sumgen Biotech Co., Ltd. • Aim: Disease control
Last updated Aug 18, 2026 02:00 UTC
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New Two-Step therapy aims to stop chronic kidney transplant rejection
Disease control Not yet recruitingThis study tests a new treatment for chronic active antibody-mediated rejection (caABMR) in kidney transplant recipients. Patients receive a single injection of a CD38 monoclonal antibody to deplete harmful immune cells, followed by long-term azathioprine pills to maintain contro…
Phase: NA • Sponsor: wujianyong • Aim: Disease control
Last updated Jul 23, 2026 00:00 UTC
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New hope for kidney transplant patients: drug targets rejection
Disease control Not yet recruitingThis study tests a drug called mezagitamab in people who have had a kidney transplant and are experiencing a type of rejection called antibody-mediated rejection (AMR). AMR happens when the body's immune system attacks the donor kidney, which can lead to kidney failure. The study…
Phase: PHASE2 • Sponsor: Takeda • Aim: Disease control
Last updated Jun 27, 2026 13:02 UTC
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New study aims to unlock secrets of kidney transplant rejection
Knowledge-focused Not yet recruitingThis observational study at the University of Pittsburgh will enroll 24 kidney transplant recipients to deeply analyze why some rejections are stubborn. Researchers will use biopsies and blood samples to map immune cells and genetic changes. The goal is to better predict and unde…
Sponsor: University of Pittsburgh • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:06 UTC
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New MRI technique aims to spot kidney transplant rejection early
Knowledge-focused Not yet recruitingThis study will use advanced MRI scans to look at kidney transplants in 140 patients. The goal is to see if MRI can measure how well the kidney is working and tell the difference between stable function and problems like rejection. Researchers hope this could lead to a non-invasi…
Sponsor: University of Minnesota • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:52 UTC