Acute transplant rejection
MONDO:1010187A transplant rejection that is caused by an immune response directed against the graft and occurs between 1 week and several months after transplantation. Acute rejection is diagnosed on histological analysis of a graft biopsy. Acute rejection is thought to result from two immunological mechanisms that may act alone or in combination: (1) a T-cell-dependent process that corresponds to acute cellular rejection, and (2) a B-cell-dependent process that generates the acute humoral rejection.
35 clinical trials for this condition and its sub-types.
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Fat stem cells infused into kidney artery to fight transplant rejection
Disease control CompletedThis early-stage trial tests whether a single infusion of stem cells from donated fat tissue can safely treat rejection in kidney transplant recipients. The cells are delivered directly into the kidney artery. The study includes 12 adults with biopsy-proven rejection and aims to …
Phase: PHASE1 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated Jul 03, 2026 00:00 UTC
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Can a single drug save rejected kidneys? new trial investigates
Disease control CompletedThis study tested whether adding the drug rituximab to standard care could stop acute rejection in kidney transplant patients. 40 adults who had a kidney transplant within the past year and showed signs of acute humoral rejection took part. The main goal was to see if rituximab c…
Phase: PHASE3 • Sponsor: University Hospital, Tours • Aim: Disease control
Last updated Jun 27, 2026 13:07 UTC
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Kidney transplant study: which drug better prevents rejection?
Disease control CompletedThis study tested two different drug combinations (Simulect or ATG, plus standard medications) in 60 kidney transplant patients at high risk of rejection. The goal was to see which approach better prevents treatment failure, including rejection, graft loss, or death, within 6 mon…
Phase: PHASE4 • Sponsor: University Hospital, Toulouse • Aim: Disease control
Last updated Jun 27, 2026 12:05 UTC
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New drug cocktail aims to stop kidney rejection
Disease control CompletedThis study tested whether adding the drug bortezomib to a standard treatment (rituximab, plasma exchange, and IVIG) helps control antibody-mediated rejection in kidney transplant patients. Twenty participants were enrolled, and researchers measured kidney function and rejection m…
Phase: NA • Sponsor: Shahid Beheshti University of Medical Sciences • Aim: Disease control
Last updated Jun 26, 2026 15:09 UTC
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New test could spot transplant rejection without a biopsy
Knowledge-focused CompletedThis study looked at whether proteins in ostomy fluid (waste from the intestine) can signal rejection after an intestinal transplant. Currently, doctors must take tissue samples through a scope to check for rejection, which is invasive and not always accurate. Researchers analyze…
Sponsor: University of California, Los Angeles • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:08 UTC
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Tiny virus may hold key to better kidney transplant care
Knowledge-focused CompletedThis study looked at whether levels of a common virus called Torque teno virus (TTV) can help doctors monitor how well a kidney transplant patient's immune system is suppressed. The goal is to find a simple blood test that could predict rejection or infection. Researchers followe…
Sponsor: Queen Mary University of London • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:07 UTC
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Lung transplant infection study aims to improve Long-Term survival
Knowledge-focused CompletedThis study followed 600 lung transplant recipients at the University of Pittsburgh to see how common viral and bacterial infections are and how they affect long-term health. Researchers focused on whether a specific infection (C. pneumoniae) is linked to a condition called bronch…
Sponsor: University of Pittsburgh • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:10 UTC