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Achalasia
MONDO:0008698A finding indicating the lack of adequate relaxation of the lower esophageal sphincter resulting in difficulty swallowing food.
Also known as: achalasia, achalasia (disease), achalasia of cardia, achalasia of oesophagus, cardiospasm, esophageal achalasia
48 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsSub-types
Broader categories
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Battle of the balloons: which achalasia treatment wins?
Disease control CompletedThis study compared two procedures for treating achalasia, a condition where the esophagus doesn't relax properly. One is a balloon dilation (pneumodilation) and the other is a surgery called POEM done through a scope. 132 adults with achalasia were randomly assigned to one treat…
Phase: NA • Sponsor: KU Leuven • Aim: Disease control
Last updated Jun 27, 2026 12:00 UTC
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Simple drug may cut infection risk after major gut surgery
Disease control CompletedThis study tested whether tranexamic acid, a drug that helps blood clot, can lower the chance of infection after gastrointestinal surgery. Over 3,300 adults at higher risk for complications took part. The goal was to see if the drug reduces surgical site infections compared to a …
Phase: PHASE4 • Sponsor: Bayside Health • Aim: Disease control
Last updated Jun 27, 2026 08:07 UTC
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New scope treatment eases swallowing woes
Disease control CompletedThis study tested a new procedure called POEM for people with achalasia, a condition where the esophagus doesn't relax properly, making swallowing hard. In POEM, doctors cut the tight muscle through a small tunnel inside the esophagus, without any cuts on the outside. The goal wa…
Phase: NA • Sponsor: Hadassah Medical Organization • Aim: Disease control
Last updated Jun 27, 2026 07:52 UTC
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Can an online wellness program ease anxiety in chronic disease?
Symptom relief CompletedThis study tested a 12-week online mind-body program for adults with chronic conditions like heart failure, cancer, and liver disease. The program included mindful movement, meditation, breathwork, and coping skills. Researchers measured changes in anxiety, depression, fatigue, a…
Phase: NA • Sponsor: University of Alberta • Aim: Symptom relief
Last updated Jun 27, 2026 12:31 UTC
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New hope for preventing Post-Surgery confusion in seniors
Symptom relief CompletedThis study tested whether giving a small amount of s-ketamine during chest surgery could reduce the risk of postoperative delirium (sudden confusion) in patients aged 60 and older. Over 500 participants were randomly assigned to receive either s-ketamine or another drug (dexmedet…
Phase: EARLY_PHASE1 • Sponsor: Affiliated Cancer Hospital & Institute of Guangzhou Medical University • Aim: Symptom relief
Last updated Jun 27, 2026 12:28 UTC
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Botox for the esophagus: new hope for swallowing pain?
Symptom relief CompletedThis study tested whether injecting botulinum toxin (like Botox) into the lower esophagus can ease symptoms of nutcracker esophagus, a condition that causes chest pain and trouble swallowing. Twenty-four adults received either the toxin or a placebo in a double-blind setup. The m…
Phase: PHASE2 • Sponsor: Hospices Civils de Lyon • Aim: Symptom relief
Last updated Jun 27, 2026 08:05 UTC
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Surgery showdown: laparoscopic vs open for swallowing disorder
Symptom relief CompletedThis study looked at 38 people with achalasia cardia, a condition where the esophagus muscle doesn't relax, making swallowing difficult. Half had laparoscopic (minimally invasive) surgery and half had open surgery. Researchers measured symptoms and quality of life before and afte…
Sponsor: Osh State University • Aim: Symptom relief
Last updated Jun 26, 2026 18:23 UTC
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Small study seeks clues to weight loss mystery in achalasia
Knowledge-focused CompletedThis study looked at 7 adults with achalasia, a swallowing disorder, to find out why some lose weight and others don't. Researchers monitored body weight and compared differences between the two groups. The goal was to gather information that could lead to better understanding an…
Sponsor: Vanderbilt University Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:37 UTC
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Dye test could catch hidden cancer in achalasia patients
Knowledge-focused CompletedPeople with achalasia, a swallowing disorder, have a much higher risk of developing esophageal cancer. This study tested whether spraying a special dye (Lugol) during an endoscopy could help doctors find early signs of cancer (dysplasia) in 39 patients who had achalasia for over …
Phase: NA • Sponsor: KU Leuven • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:03 UTC
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Blood antibodies may reveal hidden clues in rare swallowing disorder
Knowledge-focused CompletedThis study looked at 195 adults with achalasia, a rare condition that makes it hard to swallow. Researchers checked if certain antibodies in the blood are linked to how severe the disease is and how well patients respond to a treatment called POEM. The goal was to see if these an…
Sponsor: Peking Union Medical College Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:10 UTC