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127005 trials found · Page 5518 of 6351
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Brain surgery probe could unlock tumor secrets
Knowledge-focused Recruiting nowThis clinical trial evaluates the use of microdialysis catheters during surgery to collect biomarkers, and studies the feasibility of intra- and post-operative microdialysis during neurosurgery for central nervous system malignancies. A biomarker is a measurable indicator of the …
Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Aug 20, 2026 00:00 UTC
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Massive hospital data dive aims to uncover liver Disease's hidden links
Knowledge-focused Recruiting nowExamine the association of chronic liver diseases (including hepatitis B, hepatitis C, alcoholic liver disease, fatty liver, liver cirrhosis, and hepatocellular carcinoma) with other systemic diseases by retrospectively analyzing the data from the Hospital Database of Buddhist Tz…
Sponsor: Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation • Aim: Knowledge-focused
Last updated Jun 26, 2026 19:12 UTC
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Scientists use brain scans to unlock secrets of alcohol cravings
Knowledge-focused CompletedThis study uses techniques from an area of research known as neuroeconomics, which integrates concepts and methods from psychology, neuroscience, and economics to better understand how people make decisions and how these decisions are supported by the brain. One neuroeconomic con…
Sponsor: McMaster University • Aim: Knowledge-focused
Last updated Jun 26, 2026 15:19 UTC
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Nationwide french study aims to settle debate on best way to remove large colon polyps
Knowledge-focused Recruiting nowInitially developed in Japan for the treatment of endemic superficial gastric cancers, endoscopic submucosal dissection (ESD) allows resection of pre-neoplastic and neoplastic lesions of the digestive tract into a single fragment. It allows a perfect pathological analysis, and de…
Sponsor: University Hospital, Limoges • Aim: Knowledge-focused
Last updated Jun 26, 2026 17:05 UTC
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Your diet may determine if your hip surgery succeeds
Knowledge-focused CompletedA multicentre retrospective cohort study was conducted within the Department of Orthopaedics at the First Affiliated Hospital of Fujian Medical University. This study reviewed 1,296 patients who underwent internal fixation treatment with ITF at the institution between 2020 and 20…
Sponsor: First Affiliated Hospital of Fujian Medical University • Aim: Knowledge-focused
Last updated Jun 26, 2026 15:14 UTC
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New method could help tiny preemies grow better
Knowledge-focused CompletedThis randomized controlled trial included 100 preterm and small for gestational age neonates. The study aimed to determine the optimal approach for estimating nutritional needs in parenteral nutrition (PN) with the assistance of a specialized clinical decision support system (CDS…
Sponsor: Panos Papandreou • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:58 UTC
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PET scan breakthrough: spotting brain tumors vs. Look-Alikes
Diagnosis CompletedBackground: 3,4-dihydroxy-6-\[18F\]-fluoro-L-phenylalanine (FDOPA) positron emission tomography (PET) can identify well low and high grade brain tumors. However, increased FDOPA uptake has been reported in non-tumoral brain lesions. The aim was to analyse FDOPA-PET in patients wi…
Sponsor: Centre Hospitalier Universitaire de Nīmes • Aim: Diagnosis
Last updated Jun 27, 2026 08:01 UTC
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Blood test may predict catatonia drug response
Knowledge-focused Recruiting nowCatatonia is a severe form of psychomotor disturbance with a heterogenous presentation. It affects approximately 10% of acute psychiatric inpatients. According to the fifth edition of DSM-5 the diagnosis of catatonia can be made when three or more symptoms from the twelve followi…
Sponsor: University Hospital, Lille • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:36 UTC
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Gene clues could personalize Crohn's treatment
Knowledge-focused CompletedFrom January 2020 to May 2025, 303 CD patients and 514 normal controls were retrospectively collected from Department of Gastroenterology, the Second Affiliated Hospital of Wenzhou Medical University. Our study aimed to explore the the relationship of interleukin-7 receptor (IL-7…
Sponsor: Second Affiliated Hospital of Wenzhou Medical University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:01 UTC
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New stitching method may speed up gallstone surgery
Knowledge-focused CompletedThis observational study aims to compare two techniques for closing the common bile duct incision (choledochotomy) after laparoscopic common bile duct exploration (LCBDE) with T-tube drainage. Interrupted suturing is commonly used, but it can be time-consuming during laparoscopic…
Sponsor: Yantai Affiliated Hospital of Binzhou Medical University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:11 UTC
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Dialysis patients try simple exercises to boost health
Symptom relief CompletedThis study examined whether different types of exercise performed during hemodialysis sessions affect patients' health and quality of life. Patients receiving regular hemodialysis were assigned to resistance exercise, flexibility exercise, or usual care during dialysis. Changes i…
Sponsor: Dilek GİBYELİ GENEK • Aim: Symptom relief
Last updated Jun 27, 2026 09:02 UTC
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Gene clues could personalize ulcerative colitis treatment
Knowledge-focused CompletedFrom January 2020 to December 2024, diagnosed ulcerative colitis(UC) patients and gender- and age-matched normal controls were enrolled from the Department of Gastroenterology, the Second Affiliated Hospital of Wenzhou Medical University. Investigators' aim is to investigate the …
Phase 4 • Sponsor: Second Affiliated Hospital of Wenzhou Medical University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:03 UTC
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MRI may sharpen radiation aim in esophageal cancer
Knowledge-focused CompletedEsophageal cancer radiotherapy requires accurate delineation of the gross tumor volume (GTV) to ensure adequate tumor coverage and to minimize radiation dose to surrounding organs at risk. Computed tomography (CT) is routinely used for target delineation, while positron emission …
Sponsor: Institute of Oncology Ljubljana • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:06 UTC
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10 years after ACL surgery: researchers use MRI to peek inside knees for early arthritis clues
Knowledge-focused By invitation onlyIn this study, a total of 219 subjects from the MOON nested cohort will be studied at CCF, Vanderbilt and OSU, Table 1. Among them, some will have added MRI during their 10-year visit for the MOON study. Some subjects who finished their 10-year visit for the MOON Onsite study alr…
Sponsor: The Cleveland Clinic • Aim: Knowledge-focused
Last updated Aug 26, 2026 00:00 UTC
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Which pain block works best for gallbladder surgery?
Symptom relief CompletedSixty patients with ASA (American Society of Anesthesiologist) I-II physical status between the ages of 20-60 were randomized into three groups: TAP block group (Group T), ESP block group (Group E) and PVB group (Group P). Bilateral 20cc (total 40cc for each patient) 0.25% bupiva…
Sponsor: Yuzuncu Yil University • Aim: Symptom relief
Last updated Jun 27, 2026 09:10 UTC
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Invisible aligners take on metal braces in jaw surgery showdown
Knowledge-focused CompletedThis retrospective single-center observational study compared perioperative and early postoperative outcomes in patients undergoing orthognathic surgery after orthodontic preparation with either conventional fixed brackets or clear aligners. The objective was to assess whether al…
Sponsor: Centre Hospitalier Universitaire de Nice • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:04 UTC
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Ultrasound ruler may cut repeat breast surgeries
Knowledge-focused CompletedThe aim of this study is to evaluate whether standardizing intraoperative ultrasound (IOUS) with the "Tübingen Ultrasound Ruler" reduces R1 resection rates in breast-conserving surgery.
Sponsor: University Hospital Tuebingen • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:05 UTC
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Stapler showdown: which tool is better for stomach cancer surgery?
Knowledge-focused Recruiting nowWith the development of stapler devices, various methods of esophagojejunostomy after laparoscopic total gastrectomy were evoluated. Which stapler is more advantageous has not been determined. At present, the most commonly used is linear stapler or Circular stapler in esophagojej…
Sponsor: Nanchong Central Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:03 UTC
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Can computer predict your new face after jaw surgery? study says maybe.
Knowledge-focused CompletedThis study aims to evaluate the accuracy of "Dolphin 3D" software for prediction of soft tissue changes in management of patients seeking orthognathic surgery to treat their mandibular deformities and collecting their feedback regarding aesthetic satisfaction.
Sponsor: Ain Shams University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:25 UTC
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Fitness check may guide better leukemia care for seniors
Knowledge-focused OngoingThe study aims to evaluate the outcome of patients (overall survival) who received treatments commensurate with the proposed "Fitness" parameters compared to that of patients whose treatment differed either in the direction of greater or lesser aggressiveness than that proposed (…
Sponsor: Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:36 UTC