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127005 trials found · Page 5456 of 6351
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No-Marker tumor tracking could make lung cancer radiation safer
Knowledge-focused OngoingIn radiotherapy, tumour tracking allows us to ensure the radiation beam is accurately targeting the tumour while it moves in a complex and unpredictable way. Most tumour tracking techniques require the implantation of fiducial markers around the tumour. Markerless Tumour Tracking…
Sponsor: Royal North Shore Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:00 UTC
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New study shows Drug-Coated balloons help patients walk better and hurt less
Disease control CompletedThis study is part of the subordination for the renewal of the registration of the LUTONIXR035 or RANGERTM drug coated balloon catheter by the CNEDiMTS following the transmission of the results of a French study on quality of life (evaluation of pain relief and walking evaluation…
Sponsor: Centre Hospitalier Universitaire Dijon • Aim: Disease control
Last updated Jun 27, 2026 09:04 UTC
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Heart attack drug trial halted early: Colchicine's nerve protection unproven
Disease control Stopped earlyThis study evaluates the benefit of colchicine on induced denervation after myocardial infarction. Patients who have suffered a documented De Novo myocardial infarction and completed a revascularization procedure will receive either colchicine on top of standard therapy, compared…
Phase 2/3 • Sponsor: University Hospital, Montpellier • Aim: Disease control
Last updated Jun 27, 2026 13:06 UTC
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Study tests best prosthetic foot for parents carrying toddlers
Knowledge-focused CompletedThe aim of this research is to identify the prosthetic foot that results in improved walking performance when individuals with lower limb amputation carry infants, toddlers, or other loads.
Sponsor: VA Puget Sound Health Care System • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:04 UTC
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Walking through chemo: new study tests exercise for older breast cancer patients
Symptom relief OngoingThis clinical trial evaluates the feasibility of exercise during chemotherapy in older women with stage I-III breast cancer. Previous studies have reported that exercise may reduce the chemotherapy-toxicity risk. This trial may help researchers learn if engaging in a physical act…
Sponsor: M.D. Anderson Cancer Center • Aim: Symptom relief
Last updated Aug 16, 2026 00:00 UTC
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What do parents really think about opioids for kids with cancer?
Knowledge-focused OngoingThis study investigates parents' attitudes and beliefs on the risks of opioid use in children with cancer. Pain is the common symptom reported by pediatric cancer patients. Opioids are the mainstay in the treatment of cancer-related pain. Despite an almost universal desire to pre…
Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:28 UTC
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Million-Patient data dive aims to make ICU care safer
Knowledge-focused Recruiting nowThe availability of electronic documentation systems in patient care means that large amounts of clinical routine data are available from which conclusions can be drawn for improving patient care. Compared to conventional research approaches, a data science-oriented approach offe…
Sponsor: Charite University, Berlin, Germany • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:02 UTC
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Ear stimulation zaps stress in overworked healthcare workers
Symptom relief CompletedThe aim of the study is to evaluate whether auricular stimulation (percutaneous sensory stimulation of cranial nerves) as compared vs. no intervention (waiting list) reduces stress and anxiety in health care providers, working at the time of COVID-19 pandemic at the University Me…
Sponsor: University Medicine Greifswald • Aim: Symptom relief
Last updated Jun 27, 2026 13:06 UTC
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Virtual reality headsets ease pain during knee treatment, study finds
Symptom relief CompletedThe study team aims to investigate whether implementing virtual reality therapy (VRT) during Genicular nerve radiofrequency ablation (GNRFA) procedure will provide better alleviation of procedural pain and augmented satisfaction for patients.
Sponsor: University of California, Irvine • Aim: Symptom relief
Last updated Jun 27, 2026 12:36 UTC
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Cholesterol drug shows promise in early leukemia trial
Disease control CompletedThis is a phase I, dose-escalation, open-label clinical trial determining the safety and tolerability of adding Pitavastatin to Venetoclax in subjects with chronic lymphocytic leukemia (CLL) or acute myeloid leukemia (AML). These are subjects who are newly diagnosed subjects with…
Phase 1 • Sponsor: University of California, Irvine • Aim: Disease control
Last updated Jun 26, 2026 15:42 UTC
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New filler shows promise for dark Under-Eye hollows
Symptom relief CompletedThis is a multicenter, blinded evaluator, randomized, prospective, no treatment control clinical study to identify whether RHA® Redensity Eye (\*) is superior to no treatment for the correction of moderate to severe tissue volume deficiencies in the infraorbital regions. The stu…
Sponsor: Teoxane SA • Aim: Symptom relief
Last updated Jun 27, 2026 08:14 UTC
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Heart surgery damage: new study uses MRI to uncover hidden injury
Knowledge-focused CompletedCardiac surgery under cardiopulmonary bypass (CPB) induces myocardial ischemia-reperfusion injury. This myocardial attack is a well-identified independent prognostic factor of postoperative morbidity and mortality. The quantification of these myocardial lesions by the postoperati…
Sponsor: Hospices Civils de Lyon • Aim: Knowledge-focused
Last updated Jun 26, 2026 16:42 UTC
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Microscope or loupes? study tests better tool for liver transplant bile duct repair
Knowledge-focused CompletedComparison of biliary complications in right lobe living donor liver transplantation patients undergoing biliary reconstructions using microscope versus surgical loupes .
Sponsor: Istanbul Medipol University Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:05 UTC
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Heart failure patients: does stress make it worse?
Knowledge-focused CompletedThe purpose of this study is to investigate whether acute stress can precipitate congestive heart failure (CHF) exacerbation in patients with CHF.
Sponsor: Yale University • Aim: Knowledge-focused
Last updated Aug 20, 2026 00:00 UTC
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Epilepsy surgery study tracks Patients' mental health over time
Knowledge-focused Recruiting nowThe aim of the study is to describe the socio-demographic, clinical, psychological, and psychiatric characteristics of patients with drug-resistant focal epilepsy eligible for epilepsy surgery and any changes in these parameters over time after surgery. Additionally, the study se…
Sponsor: Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:05 UTC
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New toolkit aims to close colonoscopy gap in rural illinois
Knowledge-focused CompletedLess than half of all positive fecal immunochemical testing (FIT)s are followed-up by colonoscopy, thus limiting the full potential of colorectal cancer (CRC) screening to reduce mortality. Given the need for coordination in order to achieve high rates of follow-up, multilevel ap…
Sponsor: Washington University School of Medicine • Aim: Knowledge-focused
Last updated Aug 07, 2026 00:00 UTC
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Thumb arthritis pain relief: steroid shot vs. placebo
Symptom relief CompletedThis randomized clinical trial (RCT) will evaluate 6-month outcomes following intra-articular injections for arthritis of the thumb carpometacarpal (CMC) joint by comparing corticosteroid plus local anesthetic versus saline (placebo) plus local anesthetic.
Phase 4 • Sponsor: University of Alberta • Aim: Symptom relief
Last updated Jun 27, 2026 12:03 UTC
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Depression and heart disease: new study seeks clues to improve survival
Knowledge-focused CompletedDepression doubles the risk of death in patients with coronary heart disease (CHD), but so far, there is insufficient evidence that we can reduce the risk of death by treating depression. This study will investigate the cardiac risk markers that are associated with depression sym…
Sponsor: Washington University School of Medicine • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:06 UTC
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New study aims to fill gap in sexual health support for breast cancer patients
Knowledge-focused CompletedIn the present study, we propose a mixed methods approach to characterize and address the sexual health needs among women with breast cancer at the time of diagnosis and throughout treatment.
Sponsor: University of Colorado, Denver • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:00 UTC
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Hidden amyloid in heart valves: a new clue in aortic stenosis?
Knowledge-focused Recruiting nowCardiac amyloidosis is a restrictive cardiomyopathy with a potentially severe prognosis that can be life-threatening. It is linked in the vast majority of cases to a light chain deposition of immunoglobulin or transthyretin. Although myocardial involvement is predominant, other l…
Sponsor: University Hospital, Toulouse • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:00 UTC