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116076 trials found · Page 5227 of 5804
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Could a simple breathing trick ease POTS symptoms?
Symptom relief OngoingThe investigators will test whether breathing through an inspiratory resistance device will improve the ability to be upright and decrease heart rate increases on standing in patients with postural tachycardia syndrome.
Phase: NA • Sponsor: Alfredo Gamboa • Aim: Symptom relief
Last updated Jun 27, 2026 08:06 UTC
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Can a sound training program help deaf kids with cochlear implants speak better?
Knowledge-focused CompletedThe cochlear implant appears today as one of the best technique so as to lead the congenital deaf children to speak. However the results in terms of accurate access to language remain partial. These results are usually due to the children own factors (social, educational and hand…
Phase: NA • Sponsor: Assistance Publique Hopitaux De Marseille • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:30 UTC
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Massive U.S. mammography registry aims to sharpen breast cancer detection
Knowledge-focused Recruiting nowThe National Mammography Database (NMD) leverages data that radiology practices are already collecting under federal mandate by providing them with comparative information for national and regional benchmarking. Participants receive semi-annual feedback reports that include impor…
Sponsor: American College of Radiology • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:52 UTC
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Xenon gas vs standard anesthetic: which keeps blood pressure steadier during carotid surgery?
Knowledge-focused CompletedThe purpose of this study is to compare the hemodynamics effects of two usual hypnotic agents (LENOXe ™ (xenon 100 % v/v) and sevoflurane) during a general anesthesia for carotid endarterectomy in elderly patients. The hypothesis is that the use of the LENOXe ™ (xenon 100 % v/v) …
Phase: PHASE4 • Sponsor: Air Liquide Santé International • Aim: Knowledge-focused
Last updated Jun 26, 2026 15:54 UTC
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Depression genes under the microscope: new study aims to uncover clues
Knowledge-focused CompletedMajor Depressive Episode (MDE) affects nearly 15% of the general population. In a preliminary study, the investigators identified 12 genes whose expression was either altered between patient and control samples and/or between first patient samples and samples from the same patien…
Phase: NA • Sponsor: Assistance Publique Hopitaux De Marseille • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:30 UTC
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Could your genes predict rotator cuff tears?
Knowledge-focused ENROLLING_BY_INVITATIONThis study will begin to evaluate the heritability of rotator cuff disease, and begin creation of a powerful resource for future genetic studies of rotator cuff disease.
Sponsor: University of Utah • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:29 UTC
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Blood clot protein may reveal Cancer's next move
Knowledge-focused CompletedSeverity of colorectal cancer (CRC) is evaluated by its local staging, locoregional and general ( presence of metastases , usually liver ). This is the most common cancer in France and, despite surgical treatment of the primary tumor, it is still subject to a high mortality rate …
Phase: EARLY_PHASE1 • Sponsor: University Hospital, Lille • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:06 UTC
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NCI launches 15-Year checkup for cell therapy volunteers
Knowledge-focused ENROLLING_BY_INVITATIONBackground: The NCI Surgery Branch has developed experimental therapies that involve taking white blood cells from participants' tumor or from their blood, growing them in the laboratory in large numbers, and then giving the cells back to the patient. Objective: This study wil…
Sponsor: National Cancer Institute (NCI) • Aim: Knowledge-focused
Last updated Jul 04, 2026 00:00 UTC
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Blood tests may predict chronic pain after spinal injury
Knowledge-focused CompletedThe investigators propose to compare plasma protein profiles for SCI patients with/without chronic neuropathic pain in order identify biomarker(s) that are associated with this medical condition. Secondly, the investigators propose to identify a temporal relationship to initial S…
Sponsor: The University of Texas Health Science Center, Houston • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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Heart valve mismatch mystery: does it really matter after surgery?
Knowledge-focused CompletedThe real impact of the existence of an aortic valve mismatch after aortic valve replacement in various studies conducted so far is a source of controversy. There is currently no long-term impact of the aortic valve mismatch on the reversal of left ventricular remodeling and its i…
Phase: NA • Sponsor: University Hospital, Strasbourg, France • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:03 UTC
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Smart pumps may prevent dangerous drops in blood pressure during drug swaps
Knowledge-focused CompletedCirculatory failures are the main cause of admissions in the intensive care unit. It is recommended to prescribe to these patients an intravenous injection of catecholamine to correct this dysfunction and to keep an hemodynamic stability. Electric pumps are used to administrate a…
Phase: NA • Sponsor: Centre Hospitalier Departemental Vendee • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:58 UTC
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Which ultrasound technique works best for knee arthritis?
Symptom relief CompletedKnee osteoarthritis is a common condition that causes pain, stiffness, and reduced physical function. Therapeutic ultrasound is frequently used in physical medicine and rehabilitation to reduce pain and improve joint function in patients with knee osteoarthritis; however, differe…
Phase: NA • Sponsor: Kanuni Sultan Suleyman Training and Research Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 08:09 UTC
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20-Year study to unlock secrets of pregnancy and child health
Knowledge-focused OngoingThis study aims to examine the role of genetic and epigenetic factors, maternal nutrition, lifestyle, emotional health, and other environmental factors in pregnancy or postpartum period that can influence future maternal risk of metabolic and mental wellness, including body weigh…
Sponsor: National University Hospital, Singapore • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:03 UTC
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New scan could help doctors see hidden tumor oxygen levels
Knowledge-focused CompletedHypoxia is recognized to be an independent predictor of clinical outcome in oncology. PET using \[18F\]-FMISO has been described to be useful for the non invasive assessment of hypoxia in cancer. The use of this radiotracer for brain tumours is very limited and there is no standa…
Phase: PHASE2 • Sponsor: University Hospital, Bordeaux • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:33 UTC
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Massive study tracks radiation therapy results to improve cancer care
Knowledge-focused Recruiting nowThe purpose of this research study is to collect and analyze information from patients being treated with various forms of radiation therapy.
Sponsor: Proton Collaborative Group • Aim: Knowledge-focused
Last updated Jul 12, 2026 00:00 UTC
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Back surgery showdown: which fusion technique works best?
Disease control CompletedThis trial, conducted in adult patients with degenerative spondylolisthesis needing surgical treatment at one level, aimed at comparing two approaches of spinal fusion.
Phase: NA • Sponsor: University Hospital, Bordeaux • Aim: Disease control
Last updated Jun 27, 2026 12:34 UTC
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New imaging technique could help doctors predict cancer treatment response
Knowledge-focused CompletedHead and neck cancer is the sixth most frequent cancer worldwide, excluding lymphomas and skin cancer. If 18FDG PET is considered today as a standard tool in patients with head and neck squamous cell carcinoma (HNSCC) not only for tumoral or nodal staging but also for assessment …
Phase: NA • Sponsor: University Hospital, Bordeaux • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:32 UTC
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New registry aims to uncover why some osteoporosis patients get rare fractures
Knowledge-focused Recruiting nowOsteoporosis is a disease characterized by increased bone fragility and deteriorating bone micro-architecture. The main consequence of osteoporosis is low-trauma fractures, most often of the hip, spine and wrist. Recently, another type of low-trauma fracture, atypical femur fract…
Sponsor: University Health Network, Toronto • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:31 UTC
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Massive cancer registry aims to unlock genetic secrets of bladder cancer
Knowledge-focused OngoingThis study is being done to create a registry to help us learn more about urinary and other cancers. This will let us look at large groups of people who do and do not have this kind of cancer. The investigators will look at risk factors to learn more about how these impact cance…
Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Knowledge-focused
Last updated Jun 26, 2026 13:53 UTC
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Blood test could predict lupus flares
Knowledge-focused CompletedLupus erythematosus systemic is an auto-immune disease the evaluation of the activity of which remains very difficult because of an heterogeneousness of the clinical and biological symptoms. The aim of this study is to develop objective, specific and not invasive methods of evalu…
Phase: NA • Sponsor: Assistance Publique Hopitaux De Marseille • Aim: Knowledge-focused
Last updated Jun 26, 2026 18:27 UTC